INT88245

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Context Info
Confidence 0.53
First Reported 2000
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 18.86
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc11a1) plasma membrane (Slc11a1) lysosome (Slc11a1)
Anatomy Link Frequency
bladder 7
T cell 2
J82 1
brain 1
vesicles 1
Slc11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 202 99.84 Very High Very High Very High
cytokine 917 99.72 Very High Very High Very High
Inflammation 857 99.54 Very High Very High Very High
Inflammatory response 106 99.32 Very High Very High Very High
Inflammatory stimuli 83 97.76 Very High Very High Very High
palliative 1 92.72 High High
interstitial cystitis 59 87.00 High High
headache 9 74.56 Quite High
pruritus 8 69.52 Quite High
ketamine 6 66.20 Quite High
Disease Link Frequency Relevance Heat
Infection 330 100.00 Very High Very High Very High
Targeted Disruption 24 100.00 Very High Very High Very High
Overactive Bladder 230 99.98 Very High Very High Very High
Bordatella Infection 12 99.96 Very High Very High Very High
Asthma 68 99.84 Very High Very High Very High
Cancer 596 99.58 Very High Very High Very High
INFLAMMATION 1044 99.54 Very High Very High Very High
Anaphylaxis 2 98.60 Very High Very High Very High
Bladder Cancer 295 98.20 Very High Very High Very High
Bacterial Infection 8 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional File 15 compiles genes that were expressed in the subtraction between BCG and control tissues and represent those genes up-regulated by BCG.
Gene_expression (expressed) of BCG
1) Confidence 0.53 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.06 Pain Relevance 0
The GTPases appear to be dedicated to the BCG response, since with the exception of GBP2, their resting levels in normal urothelium are negligible (Figure 3).
Gene_expression (response) of BCG
2) Confidence 0.53 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.30 Pain Relevance 0
Taken together, these results suggest that in the case of BCG vaccine, these GTPases may act as a controlled-release mechanism for the agent infecting the bladder.


Gene_expression (vaccine) of BCG in bladder
3) Confidence 0.53 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.32 Pain Relevance 0.21
It is possible that the expression of Nramp1 in mice would also confer innate immunity to infection with H. influenzae, so NTHi could colonize in the lungs of C57BL/6 mice after intranasal infection.
Gene_expression (expression) of Nramp1 in lungs associated with hemophilus infection and infection
4) Confidence 0.49 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2276502 Disease Relevance 0.70 Pain Relevance 0
The expression of Nramp1 in mice confers innate resistance to certain bacterial infections such as Mycobacterium bovis (BCG), Leishmania donovani, and S. enterica serovar Typhimurium [29,30].
Gene_expression (expression) of Nramp1 associated with bacterial infection
5) Confidence 0.49 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2276502 Disease Relevance 0.59 Pain Relevance 0
Plasmids from control- and BCG-specific differentially expressed clones and confirmed by Virtual Northern were then purified and the inserts were sequenced and annotated.
Gene_expression (expressed) of BCG
6) Confidence 0.47 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2212656 Disease Relevance 0.21 Pain Relevance 0.11
The objective of this study was to determine differentially expressed genes in the mouse bladder following repeated intravesical BCG therapy.


Gene_expression (expressed) of BCG in bladder
7) Confidence 0.47 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2212656 Disease Relevance 0.27 Pain Relevance 0.13
Subacute infection in mice with knockout of IL-4, IL-6, IL-13 or NRAMP elicits the same brain histopathology
Gene_expression (infection) of NRAMP in brain associated with targeted disruption and infection
8) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.24 Pain Relevance 0.19
in combination with the increase on IL-10 expression by rBCG-S1PT, suggests a compensatory mechanism.
Gene_expression (expression) of rBCG
9) Confidence 0.29 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.96 Pain Relevance 0.27
Nascimento et al. constructed a recombinant BCG (rBCG) expressing the genetically detoxified S1PT (rBCG-S1PT) fused with the signal sequence and under the control of the up-regulated Mycobacterium fortuitum ®-lactamase promoter.
Gene_expression (expressing) of rBCG
10) Confidence 0.29 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.68 Pain Relevance 0.11
Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model

Background

Gene_expression (expressing) of BCG in bladder associated with bordatella infection and bladder cancer
11) Confidence 0.26 Published 2008 Journal J Exp Clin Cancer Res Section Title Doc Link PMC2647907 Disease Relevance 0.66 Pain Relevance 0.03
Fold increase in mRNA expression for the BCG groups compared to normal controls was calculated as 2(-??
Gene_expression (groups) of BCG
12) Confidence 0.26 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.09 Pain Relevance 0
The BCG dose was 1 × 106 CFU/mouse once a week for one month administered periurethrally in a volume of 100 ?
Gene_expression (dose) of BCG
13) Confidence 0.26 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.60 Pain Relevance 0.13
Nascimento et al. constructed a recombinant BCG (rBCG) expressing the genetically detoxified S1PT (rBCG-S1PT) fused with the signal sequence and under the control of the up-regulated Mycobacterium fortuitum ®-lactamase promoter.
Gene_expression (expressing) of rBCG
14) Confidence 0.26 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.69 Pain Relevance 0.11
Although attempts at the use of non-specific immunomodulation with agents such as levamisole, cimetidine, alpha interferon and Bacillus Calmette-Guerin (BCG) have not produced significant clinical benefits when tested in randomized trials in both the adjuvant setting and for metastatic disease, promising results are being obtained with more specific therapy.
Neg (not) Gene_expression (produced) of BCG associated with metastasis
15) Confidence 0.20 Published 2000 Journal Cancer Treat. Rev. Section Abstract Doc Link 10814560 Disease Relevance 0.60 Pain Relevance 0.09
, IL-2, IL-3, IL-4, IL-6, IL-10,IL-17, GM-CSF, KC, and Rantes were the best discriminators of the BCG response relative to TNF-?
Gene_expression (response) of BCG associated with chemokine
16) Confidence 0.18 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.51 Pain Relevance 0.30
, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17, GM-CSF, KC, and RANTES induction discriminate between the effects of BCG relative to the inflammatory responses obtained with LPS and TNF-?
Gene_expression (effects) of BCG associated with chemokine and inflammatory response
17) Confidence 0.18 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.36 Pain Relevance 0.68
, bladder responses to BCG produce a higher PMN influx, with cells remaining well after discontinuation of the treatment.
Gene_expression (produce) of BCG in bladder
18) Confidence 0.18 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.81 Pain Relevance 0.37
Urinary TRAIL levels were initially undetectable in BCG therapy patients, but levels increased after subsequent treatments.
Gene_expression (undetectable) of BCG
19) Confidence 0.18 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.56 Pain Relevance 0.23
As the mouse does not produce IL-8, measurement of mouse KC, a functional homolog of human IL-8 [18], could give us some information regarding a role of this pro-inflammatory cytokine in mediating BCG responses.
Gene_expression (responses) of BCG associated with chemokine, inflammation and cytokine
20) Confidence 0.18 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.38 Pain Relevance 0.61

General Comments

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