INT88273

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.84
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd4) cytoplasm (Drd4) signal transducer activity (Drd4)
Anatomy Link Frequency
PBL 1
nucleus 1
prefrontal 1
midbrain 1
Drd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 156 100.00 Very High Very High Very High
dopamine receptor 33 100.00 Very High Very High Very High
monoamine 4 100.00 Very High Very High Very High
Migraine 5 99.12 Very High Very High Very High
midbrain 8 98.16 Very High Very High Very High
opiate 2 96.56 Very High Very High Very High
drug abuse 8 95.64 Very High Very High Very High
Neuropeptide 2 95.28 Very High Very High Very High
headache 6 92.24 High High
Anterior cingulate 1 86.04 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 18 99.28 Very High Very High Very High
Headache 5 99.12 Very High Very High Very High
Drug Dependence 12 95.64 Very High Very High Very High
Migraine Without Aura 1 95.04 Very High Very High Very High
Schizophrenia 221 91.32 High High
Headache Disorders 3 88.96 High High
Targeted Disruption 3 74.16 Quite High
Hypersensitivity 1 64.24 Quite High
Congenital Anomalies 48 50.00 Quite Low
Cognitive Disorder 22 32.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Allele 4 of DRD4 was significantly overrepresented in patients with MO compared with both controls and CDHDA.
Gene_expression (overrepresented) of DRD4
1) Confidence 0.54 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 16930369 Disease Relevance 1.02 Pain Relevance 0.88
At 96 h after the administration of picrotoxin into the basolateral nucleus, we have observed an increase in the expression of genes associated with 18 different monoamine (ie adrenergic alpha 1, alpha 2 and beta 2, serotonergic 5HT5b and 5HT6, dopamine D4 and muscarinic m1, m2 and m3) and peptide (CCK A and B, angiotensin 1A, mu and kappa opiate, FSH, TSH, LH, GNRH, and neuropeptide Y) G-protein coupled receptors (GPCRs).
Gene_expression (expression) of dopamine D4 in nucleus associated with dopamine, neuropeptide, opiate and monoamine
2) Confidence 0.29 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15170462 Disease Relevance 0.09 Pain Relevance 0.38
As peripheral blood lymphocytes (PBL) may represent a tool for peripheral detection of neuroreceptors, we compared the expression of dopamine D3 (DRD3) and D4 (DRD4) receptors on PBL in migraine patients and in healthy controls using radioligand binding assay techniques in the presence of antidopamine D2-like receptor antibodies.
Gene_expression (expression) of DRD4 in PBL associated with dopamine and migraine
3) Confidence 0.18 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10817442 Disease Relevance 0.33 Pain Relevance 0.55
In contrast, prefrontal levels of the dopamine receptor D4 show little change with age (Weickert et al. 2007).
Gene_expression (levels) of dopamine receptor D4 in prefrontal associated with dopamine receptor
4) Confidence 0.06 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988999 Disease Relevance 0 Pain Relevance 0.43
Studies in rats and monkeys have documented D4-receptor protein in the GPi (Mrzljak et al., 1996; Rivera et al., 2003).
Gene_expression (protein) of D4-receptor
5) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.07 Pain Relevance 0.10
Another study that administered BPA to 5-day-old rats correlated the onset of hyperactivity at 4–5 weeks of age with increased DA D4 receptor expression and reduced DA transporter expression in the midbrain.173 One study of only male mice exposed to BPA prenatally and neonatally did not find changes in DA transporter,174 although a similar study found BPA increased TH and DA transporter immunoreactivity in the limbic area.175
Gene_expression (expression) of DA D4 receptor in midbrain associated with dopamine, midbrain and attention deficit hyperactivity disorder
6) Confidence 0.03 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.32 Pain Relevance 0.67

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