INT88274

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.48
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd4) cytoplasm (Drd4) signal transducer activity (Drd4)
Anatomy Link Frequency
neuronal 1
cerebral cortex 1
PBL 1
Drd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 179 100.00 Very High Very High Very High
dopamine receptor 4 100.00 Very High Very High Very High
Morphine 9 99.84 Very High Very High Very High
Opioid 2 99.68 Very High Very High Very High
gABA 5 99.16 Very High Very High Very High
Serotonin 22 99.12 Very High Very High Very High
agonist 13 98.20 Very High Very High Very High
cerebral cortex 4 97.12 Very High Very High Very High
addiction 26 96.04 Very High Very High Very High
Kinase C 1 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 184 99.08 Very High Very High Very High
Apoptosis 1 98.52 Very High Very High Very High
Opiate Addiction 1 96.04 Very High Very High Very High
Drug Dependence 22 95.68 Very High Very High Very High
Headache 5 91.20 High High
Disease 8 89.08 High High
Hypersensitivity 2 88.24 High High
Impulse Control Disorders 65 87.56 High High
Syndrome 2 87.28 High High
Alcohol Addiction 1 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these data suggest that selective activation of the D4 receptor may represent a target for the treatment of attention deficit hyperactivity disorder without the potential drug abuse liability associated with current psychostimulant therapies.
Positive_regulation (activation) of D4 receptor associated with drug abuse and attention deficit hyperactivity disorder
1) Confidence 0.69 Published 2008 Journal Behav Pharmacol Section Abstract Doc Link 19020411 Disease Relevance 0.72 Pain Relevance 0.49
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Positive_regulation (upregulated) of D4 dopamine receptor in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
2) Confidence 0.29 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.31
These findings demonstrate that genetic variation in the DRD4 gene can determine an individual’s gambling behavior in response to a dopaminergic drug challenge.
Positive_regulation (variation) of DRD4
3) Confidence 0.27 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2933850 Disease Relevance 1.14 Pain Relevance 0.16
Quantitative RT-PCR was used to validate the results and demonstrated that there were predictable increases of three GPCRs selected for this analysis, including the dopamine D4, alpha 1b, and CCK-B receptors.
Positive_regulation (increases) of dopamine D4 associated with dopamine
4) Confidence 0.24 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15170462 Disease Relevance 0.06 Pain Relevance 0.42
Hyperactivity was accompanied by decreased dopamine [162], increased DRD4 [164], and increased serotonin transporter binding in striatum but not cerebral cortex [165].
Positive_regulation (increased) of DRD4 in cerebral cortex associated with dopamine, attention deficit hyperactivity disorder, cerebral cortex and serotonin
5) Confidence 0.20 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.86 Pain Relevance 0.40
An increased density of both DRD3 (P=0.0006) and DRD4 (P=0.002) on PBL was observed in migraineurs compared with controls.
Positive_regulation (increased) of DRD4 in PBL
6) Confidence 0.11 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10817442 Disease Relevance 0.34 Pain Relevance 0.63
Phychiatr. 3 (1997) 251] showed that the 7 repeat allele of the DRD4 receptor is significantly overpresented in the opioid-dependent cohort and confers a relative risk of 2.46.
Positive_regulation (overpresented) of DRD4 receptor associated with opioid
7) Confidence 0.05 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.26 Pain Relevance 0.69

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