INT88278

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 24.45
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
mast cell 5
platelet 1
neuronal 1
testis 1
hemopoietic progenitor cells 1
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 95 100.00 Very High Very High Very High
melanocortin 1 receptor 93 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Bile 6 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Inflammation 62 99.04 Very High Very High Very High
Chronic pancreatitis 10 98.08 Very High Very High Very High
rheumatoid arthritis 231 95.84 Very High Very High Very High
cva 14 95.72 Very High Very High Very High
headache 12 94.28 High High
Disease Link Frequency Relevance Heat
Cancer 433 100.00 Very High Very High Very High
Rhinitis 13 100.00 Very High Very High Very High
Parasitic Infection 6 100.00 Very High Very High Very High
Gastritis 6 100.00 Very High Very High Very High
Functional Bowel Disorder 5 100.00 Very High Very High Very High
Gastroenteritis 5 100.00 Very High Very High Very High
Celiac Disease 4 100.00 Very High Very High Very High
Crohn's Disease 4 100.00 Very High Very High Very High
Duodenitis 2 100.00 Very High Very High Very High
Collagenous Colitis 2 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only the Sco1 and Sco5 homozygotes were able to reproduce but no progeny was ever obtained from crosses between Sow3/Sow3 males and wild-type females (data not shown).
Sow3 Binding (crosses) of
1) Confidence 0.37 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.21 Pain Relevance 0
Only the Sco1 and Sco5 homozygotes were able to reproduce but no progeny was ever obtained from crosses between Sow3/Sow3 males and wild-type females (data not shown).
Sow3 Binding (crosses) of
2) Confidence 0.37 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.21 Pain Relevance 0
PCR products were purified with the Geneclean III kit (Qbiogene) and directly sequenced using a BigDye terminator kit v1.1 (Applied Biosystems) with primers 5?
kit Binding (purified) of
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0 Pain Relevance 0
The treatment of the Kit-induced tumors had taken a promising perspective with the use of STI-571 (Imatinib, Gleevec Novartis, Basel, Switzerland), that binds to the ATP-binding site, stabilizing the autoinhibitory structure with an inactive tyrosine kinase domain [14].
Kit-induced Binding (binds) of associated with cancer
4) Confidence 0.33 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.39 Pain Relevance 0
These are now defined as spindle cell, epithelioid or occasionally pleiomorphic mesenchymal tumors that express c-kit protein immunopositivity (CD117), which is their major diagnostic criterion. [2,3,5]
CD117 Binding (criterion.) of associated with cancer
5) Confidence 0.31 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2409332 Disease Relevance 1.42 Pain Relevance 0.14
We used two-way analysis of variance (ANOVA) to characterize the interaction between genotype and UVB exposure and identified 120 and 147 genes that showed a significant interaction (p = 0.05) between UVB and Mc1r and between UVB and Kit, respectively.
Kit Binding (interaction) of in Kit
6) Confidence 0.31 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.07 Pain Relevance 0
But it is worth noting that positive staining for KIT does not necessarily indicate KIT activation or KIT mutation (Joensuu et al 2002).
KIT Binding (staining) of
7) Confidence 0.29 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 1.05 Pain Relevance 0
However, expression of exon 9 KIT oncoprotein was shown to be associated with an improved progression free survival with the higher dose schedule of imatinib.
KIT oncoprotein Binding (associated) of
8) Confidence 0.29 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.59 Pain Relevance 0
PCR products were purified with the Geneclean III kit (Qbiogene) and directly sequenced using a BigDye terminator kit v1.1 (Applied Biosystems) with primers 5?
kit Binding (using) of
9) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0 Pain Relevance 0
We have now found first, that sensory nerve populations are reduced in mutant Kit and Steel mice, implicating Steel-Kit interactions in neuronal development.
Kit Binding (interactions) of in neuronal
10) Confidence 0.29 Published 2000 Journal Neuroreport Section Abstract Doc Link 10817584 Disease Relevance 0 Pain Relevance 0.05
The skin and bone marrow biopsy revealed numerous mast cells which stained metachromatically with giemsa and toludine blue stains and showed positivity with CD68 and CD117 on immunohistochemistry.
CD117 Binding (positivity) of in mast cells
11) Confidence 0.26 Published 2006 Journal J Pak Med Assoc Section Abstract Doc Link 16900719 Disease Relevance 0.44 Pain Relevance 0.09
More than 5 mitoses per 50 high-power fields (HPF) and size greater than 10 cm are almost uniformly identified as factors associated with poor outcomes after surgery.4,6,9,10 Other factors such as nongastric primary tumor location, exon 9 mutation, or “wild type” kit also appear to be deleterious prognostic factors.9,11–13

General management

kit Binding (associated) of associated with cancer
12) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952484 Disease Relevance 0.99 Pain Relevance 0.08
Our results suggest that nearly all of this difference is likely due to the three pigmentation genes Agouti, Mc1r, and Kit, although it is formally possible that other closely linked loci affect the color difference between subspecies.
Kit Binding (due) of in pigmentation associated with melanocortin 1 receptor
13) Confidence 0.22 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.41
The cells were then trypsinized for 1 minute, centrifuged, washed with PBS, fixed in 4% paraformaldehyde for 0.5 hour at room temperature, washed and blocked in 2%FCS for 0.5 hour at room temperature with agitation. 1.5×105cells were then incubated with each of the following conjugated monoclonal antibodies: Tie-2, Flk-1, CD34, c-Kit, Thy-1, Sca-1 (PharMingen, San Diego, CA) for 90 mins at room temperature.
c-Kit Binding (temperature) of
14) Confidence 0.20 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.30 Pain Relevance 0.06
These results indicated that the present rat antisera specifically ­recognized mouse ERGIC-53 or c-Kit.


c-Kit Binding (recognized) of
15) Confidence 0.20 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790970 Disease Relevance 0.16 Pain Relevance 0
Anti-­ERGIC-53 antisera recognized acinar cells in the sublingual gland, and anti-c-Kit antisera recognized spermatogenic and Leydig cells in the testis.
c-Kit Binding (recognized) of in testis
16) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1790970 Disease Relevance 0.07 Pain Relevance 0
Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.
CD117 Binding (including) of in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis
17) Confidence 0.15 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 3.01 Pain Relevance 0.30
Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.
c-kit Binding (including) of in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis
18) Confidence 0.15 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 3.01 Pain Relevance 0.30
For semiquantitative RT-PCR, cDNA was made using random primers and the Superscript reverse transcription kit (Invitrogen) according to the manufacturer’s protocol. ?
kit Binding (according) of
19) Confidence 0.15 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0 Pain Relevance 0
EGFr, c-Kit, and CD74 staining also showed an increased mean fluorescence intensity, whereas IL-13R?
c-Kit Binding (intensity) of
20) Confidence 0.12 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.42 Pain Relevance 0

General Comments

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