INT88279

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Context Info
Confidence 0.76
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.06
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) signal transduction (Ngf) extracellular space (Ngf)
extracellular region (Ngf) plasma membrane (Ntrk1) kinase activity (Ntrk1)
Anatomy Link Frequency
neurons 2
myocyte 1
neuronal 1
sensory nerve 1
skeleton 1
Ngf (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 124 100.00 Very High Very High Very High
Trk A 11 100.00 Very High Very High Very High
nociceptor 15 99.52 Very High Very High Very High
c fibre 12 98.36 Very High Very High Very High
unmyelinated 6 98.20 Very High Very High Very High
Central nervous system 18 97.00 Very High Very High Very High
substance P 11 95.24 Very High Very High Very High
cytokine 22 92.96 High High
Inflammatory mediators 10 92.28 High High
Neurotransmitter 11 91.20 High High
Disease Link Frequency Relevance Heat
Cancer 169 100.00 Very High Very High Very High
Injury 22 97.28 Very High Very High Very High
INFLAMMATION 74 91.88 High High
Pain 109 89.72 High High
Bone Cancer 39 83.68 Quite High
Apoptosis 139 79.36 Quite High
Diabetes Mellitus 95 75.12 Quite High
Neuropathic Pain 56 70.84 Quite High
Bone Fracture 3 68.24 Quite High
Disease 230 67.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The receptor tyrosine kinase Kit thus contrasts with the receptor tyrosine kinase trkA, which is activated by the sprouting stimulus (NGF) but not by the axonal regeneration signal.
NGF Neg (not) Positive_regulation (activated) of trkA
1) Confidence 0.76 Published 2000 Journal Neuroreport Section Abstract Doc Link 10817584 Disease Relevance 0 Pain Relevance 0.04
There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [36].
NGF Spec (may) Positive_regulation (induce) of Trk A associated with nerve growth factor, trk a and substance p
2) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.58 Pain Relevance 1.13
CONCLUSION: Based on the extent of SP and trkA co-expression in airway-specific neurons by NGF treatment, the present study suggests that, following a peripheral activation of trkA receptor on SP afferent by NGF which is elevated in allergic inflammation, there may be trkA-mediated SP induction to mediate neurogenic airway inflammation.


NGF Positive_regulation (activation) of trkA in neurons
3) Confidence 0.49 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20].
NGF Positive_regulation (activate) of TrkA in neurons associated with nerve growth factor and nociceptor
4) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.68 Pain Relevance 1.21
The NGF produced by target tissues or tumor cells activates TrkA receptors expressed on the terminals of C-fibers [18,22] presumably including those innervating the skeleton.
NGF Positive_regulation (activates) of TrkA in skeleton associated with c fibre, nerve growth factor and cancer
5) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.41 Pain Relevance 1.18
It has also been shown that NGF lowers the threshold and enhances the response of nociceptors to mechanical stimuli [21], suggesting that NGF activation of TrkA may play a role in activating/sensitizing mechanotransducers expressed by sensory nerve fibers.
NGF Positive_regulation (activation) of TrkA in sensory nerve associated with nerve growth factor and nociceptor
6) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.44 Pain Relevance 1.20
Treatment of co-cultures of sympathetic neurons and cardiac myocytes with NGF, to preferentially activate neuronal TRKA, promotes the release of norepinephrine and increases the myocyte beat rate by fourfold [187].
NGF Positive_regulation (activate) of TRKA in myocyte
7) Confidence 0.14 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0 Pain Relevance 0
NGF-mediated activation of both TrkA and p75, the latter being increased following brain damage, may promote neuronal survival through activation of NF-kB [182], which can also be directly induced by most of the cytokines.
NGF Positive_regulation (activation) of TrkA in neuronal associated with cytokine
8) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.95 Pain Relevance 0.46

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