INT88282

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.77
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)
Anatomy Link Frequency
amygdala 5
brain 2
hypothalamus 1
cerebral cortex 1
hippocampus 1
Atf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 3 99.76 Very High Very High Very High
antidepressant 28 99.70 Very High Very High Very High
antagonist 2 98.36 Very High Very High Very High
nMDA receptor 2 98.20 Very High Very High Very High
cerebral cortex 7 95.80 Very High Very High Very High
Spinal cord 17 95.76 Very High Very High Very High
monoamine 4 95.36 Very High Very High Very High
Hippocampus 5 95.12 Very High Very High Very High
fluoxetine 4 94.68 High High
Calcium channel 1 94.68 High High
Disease Link Frequency Relevance Heat
Apoptosis 5 97.36 Very High Very High Very High
Spinal Cord Injury 5 92.12 High High
Neuropathic Pain 69 88.92 High High
Targeted Disruption 5 85.56 High High
Inflammatory Pain 1 82.36 Quite High
Rheumatoid Arthritis 2 81.48 Quite High
Death 1 78.40 Quite High
INFLAMMATION 10 78.24 Quite High
Stress 1 75.96 Quite High
Neurodegenerative Disease 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of cAMP-response element binding protein in brain associated with morphine
1) Confidence 0.44 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18850497 Disease Relevance 0.07 Pain Relevance 0.31
Furthermore, this effect involved phosphorylation of cAMP response element-binding protein and activation of the tropomyosin-related kinase (Trk) receptors.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of cAMP response element-binding protein
2) Confidence 0.41 Published 2008 Journal Cereb. Cortex Section Abstract Doc Link 17965127 Disease Relevance 0.56 Pain Relevance 0.43
Chronic, but not acute, administration of these antidepressants significantly increased CRE-mediated gene transcription, as well as the phosphorylation of CRE binding protein (CREB), in several limbic brain regions thought to mediate the action of antidepressants, including the cerebral cortex, hippocampus, amygdala, and hypothalamus.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CRE binding protein in amygdala associated with antidepressant, hippocampus, amygdala and cerebral cortex
3) Confidence 0.39 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.09 Pain Relevance 0.68
DADLE, itself, dose-dependently induced maximal phosphorylation of ATF-2 within 5-10min; naltrindole, a specific antagonist, abolished this.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ATF-2 associated with antagonist
4) Confidence 0.36 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.36
Chronic, but not acute, administration of these antidepressants significantly increased CRE-mediated gene transcription, as well as the phosphorylation of CRE binding protein (CREB), in several limbic brain regions thought to mediate the action of antidepressants, including the cerebral cortex, hippocampus, amygdala, and hypothalamus.
Positive_regulation (increased) of in hypothalamus Phosphorylation (phosphorylation) of CRE binding protein in amygdala associated with antidepressant, hippocampus, amygdala and cerebral cortex
5) Confidence 0.13 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.09 Pain Relevance 0.68
Chronic, but not acute, administration of these antidepressants significantly increased CRE-mediated gene transcription, as well as the phosphorylation of CRE binding protein (CREB), in several limbic brain regions thought to mediate the action of antidepressants, including the cerebral cortex, hippocampus, amygdala, and hypothalamus.
Positive_regulation (increased) of in cerebral cortex Phosphorylation (phosphorylation) of CRE binding protein in amygdala associated with antidepressant, hippocampus, amygdala and cerebral cortex
6) Confidence 0.13 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.09 Pain Relevance 0.68
Chronic, but not acute, administration of these antidepressants significantly increased CRE-mediated gene transcription, as well as the phosphorylation of CRE binding protein (CREB), in several limbic brain regions thought to mediate the action of antidepressants, including the cerebral cortex, hippocampus, amygdala, and hypothalamus.
Positive_regulation (increased) of in hippocampus Phosphorylation (phosphorylation) of CRE binding protein in amygdala associated with antidepressant, hippocampus, amygdala and cerebral cortex
7) Confidence 0.13 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.09 Pain Relevance 0.68
The increase in p38 phosphorylation is accompanied by an increase in p38 activity, as shown by elevated phosphorylation of ATF-2, a substrate of p38 (Fig 1b).
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of ATF-2
8) Confidence 0.12 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.80 Pain Relevance 1.02

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