INT88285

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 4
Total Number 5
Disease Relevance 1.56
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)
Anatomy Link Frequency
brain 1
Atf2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 15 99.84 Very High Very High Very High
Morphine 3 98.72 Very High Very High Very High
withdrawal 5 98.36 Very High Very High Very High
opiate 3 97.56 Very High Very High Very High
cytokine 2 95.84 Very High Very High Very High
cINOD 1 94.16 High High
Desipramine 2 92.28 High High
Serotonin 2 91.64 High High
Locus ceruleus 4 91.48 High High
fluoxetine 3 90.04 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.16 Very High Very High Very High
INFLAMMATION 1 93.76 High High
Morphine Dependence 1 84.36 Quite High
Depression 9 83.92 Quite High
Stress 9 83.12 Quite High
Middle Cerebral Artery Infarction 1 79.32 Quite High
Opiate Addiction 1 75.96 Quite High
Injury 3 75.20 Quite High
Death 1 71.44 Quite High
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of brain-derived neurotrophic factor (BDNF) was detected by immunohistochemistry, and mRNA expression of BDNF and cAMP response element-binding protein (CREB) analyzed by reverse transcription-polymerase chain reaction (RT-PCR).
Spec (analyzed) Transcription (expression) of cAMP response element-binding protein in brain
1) Confidence 0.36 Published 2009 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 19248161 Disease Relevance 0.96 Pain Relevance 0.35
To directly study the regulation of cAMP response element (CRE)-mediated gene transcription by antidepressants, transgenic mice with a CRE-LacZ reporter gene construct were administered one of three different classes of antidepressants: a norepinephrine selective reuptake inhibitor (desipramine), a serotonin selective reuptake inhibitor (fluoxetine), or a monoamine oxidase inhibitor (tranylcypromine).
Transcription (transcription) of cAMP response element associated with targeted disruption, desipramine, antidepressant, serotonin, monoamine and fluoxetine
2) Confidence 0.36 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.10 Pain Relevance 0.55
cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment.
Transcription (transcription) of cAMP response element associated with antidepressant
3) Confidence 0.36 Published 2000 Journal J. Neurosci. Section Title Doc Link 10818138 Disease Relevance 0.09 Pain Relevance 0.56
Downstream substrates of the p38 MAPKs include protein kinases such as MAPK-activated protein kinase 2 (MAPKAPK2) [18] and p38 regulated/activated kinase (PRAK/MAPKAPK5) [19], as well as several transcription factors including MEF2, CHOP, and ATF2 [10].
Transcription (transcription) of ATF2
4) Confidence 0.22 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.17 Pain Relevance 0.18
Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal.
Transcription (transcription) of cAMP response element associated with withdrawal and morphine
5) Confidence 0.10 Published 2002 Journal J. Neurosci. Section Title Doc Link 11978842 Disease Relevance 0.24 Pain Relevance 0.98

General Comments

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