INT88291

Context Info Confidence 0.18 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0.55

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)

Atf2 (Mus musculus)

Pain Link Frequency Relevance Heat antidepressant 7 99.84 Desipramine 1 92.28 Serotonin 1 91.64 fluoxetine 1 90.04 monoamine 1 89.32 cerebral cortex 1 52.56 Hippocampus 1 51.20 amygdala 1 50.16

Disease Link Frequency Relevance Heat Targeted Disruption 1 99.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To directly study the regulation of cAMP response element (CRE)-mediated gene transcription by antidepressants, transgenic mice with a CRE-LacZ reporter gene construct were administered one of three different classes of antidepressants: a norepinephrine selective reuptake inhibitor (desipramine), a serotonin selective reuptake inhibitor (fluoxetine), or a monoamine oxidase inhibitor (tranylcypromine).

Regulation (regulation) of Transcription (transcription) of cAMP response element associated with targeted disruption, desipramine, antidepressant, serotonin, monoamine and fluoxetine

1) Confidence 0.18 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.10 Pain Relevance 0.55

General Comments

This test has worked.