INT88291

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Context Info
Confidence 0.18
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)
Atf2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 7 99.84 Very High Very High Very High
Desipramine 1 92.28 High High
Serotonin 1 91.64 High High
fluoxetine 1 90.04 High High
monoamine 1 89.32 High High
cerebral cortex 1 52.56 Quite High
Hippocampus 1 51.20 Quite High
amygdala 1 50.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To directly study the regulation of cAMP response element (CRE)-mediated gene transcription by antidepressants, transgenic mice with a CRE-LacZ reporter gene construct were administered one of three different classes of antidepressants: a norepinephrine selective reuptake inhibitor (desipramine), a serotonin selective reuptake inhibitor (fluoxetine), or a monoamine oxidase inhibitor (tranylcypromine).
Regulation (regulation) of Transcription (transcription) of cAMP response element associated with targeted disruption, desipramine, antidepressant, serotonin, monoamine and fluoxetine
1) Confidence 0.18 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818138 Disease Relevance 0.10 Pain Relevance 0.55

General Comments

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