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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.98
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, CXCR4) cytoplasm (ITIH4, CXCR4) extracellular region (ITIH4)
cytoplasmic membrane-bounded vesicle (CXCR4) signal transducer activity (CXCR4)
Anatomy Link Frequency
neurons 1
ITIH4 (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 15 99.60 Very High Very High Very High
agonist 6 95.88 Very High Very High Very High
anesthesia 1 44.96 Quite Low
Glutamate 24 38.08 Quite Low
nMDA receptor 14 29.76 Quite Low
antagonist 14 17.04 Low Low
Opioid 7 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 27 100.00 Very High Very High Very High
Neuroblastoma 2 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 100 97.64 Very High Very High Very High
Toxicity 41 90.36 High High
Sprains And Strains 2 87.56 High High
Infection 8 74.00 Quite High
Necrosis 1 69.64 Quite High
Cancer 3 69.28 Quite High
Immunodeficiency 1 67.80 Quite High
Syndrome 3 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of CXCR4 by gp120 stimulates p53 and increases the phosphorylation of Apaf-1 (proapoptotic) in neurons [35].
gp120 Positive_regulation (Stimulation) of CXCR4 in neurons
1) Confidence 0.27 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.42 Pain Relevance 0.08
gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors.
gp120 Positive_regulation (induces) of CXCR4 associated with chemokine, neuroblastoma and death
2) Confidence 0.23 Published 2000 Journal J. Neurochem. Section Title Doc Link 10820198 Disease Relevance 1.56 Pain Relevance 0.16

General Comments

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