INT88317

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.46
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 15 100.00 Very High Very High Very High
antagonist 31 96.56 Very High Very High Very High
addiction 99 86.04 High High
Central nervous system 15 61.76 Quite High
anesthesia 3 48.24 Quite Low
nMDA receptor 2 25.00 Low Low
Potency 9 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 264 100.00 Very High Very High Very High
Infection 114 99.92 Very High Very High Very High
Immunization 1 98.02 Very High Very High Very High
Cytomegalovirus Infection 2 94.40 High High
Immunodeficiency 4 93.92 High High
Syndrome 5 92.56 High High
Sprains And Strains 25 89.20 High High
Dementia 14 85.20 High High
Cognitive Disorder 3 82.24 Quite High
Death 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha, MIP1beta, and RANTES, natural ligands of CXCR4 and CCR5, respectively, are potent soluble inhibitors of HIV infection by blocking the binding between the viral envelope glycoprotein gp120 and the coreceptors.
Negative_regulation (blocking) of gp120 Binding (binding) of associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.36 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 1.71 Pain Relevance 0.17
HNG-105 is an entry inhibitor that, similar to its parental peptide 12p1 [85,86], seems to work by a novel allosteric mechanism that involves interaction with a site in gp120 different than the CD4 or co-receptor binding sites, but results in reduced affinity of gp120 for both receptors [84].
Negative_regulation (reduced) of gp120 Binding (affinity) of
2) Confidence 0.25 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.32 Pain Relevance 0.10
These CD4-induced regions contain discontinuous structures that react with certain human neutralizing monoclonal antibodies (mAbs) (e.g., 17b), which inhibit chemokine receptor binding to gp120 [2,5,7-15], and therefore constitute a high-affinity binding site for the co-receptor molecule.
Negative_regulation (inhibit) of gp120 Binding (binding) of associated with chemokine
3) Confidence 0.22 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.55 Pain Relevance 0.19
This agent acts through allosteric inhibition of the CCR5 receptor, preventing its interaction with gp120 and thus avoiding subsequent cellular entry by HIV.
Negative_regulation (preventing) of gp120 Binding (interaction) of associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.44 Pain Relevance 0.10
There are several compounds in development that inhibit the initial interaction between gp120 and the CD4 receptor.
Negative_regulation (inhibit) of gp120 Neg (inhibit) Binding (interaction) of
5) Confidence 0.11 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.48 Pain Relevance 0.13
Besides immunostimulation, other effects of the polysaccharide–protein complexes contribute to the antiviral activity, e.g. inhibition of binding of HIV-1 gp120 to immobilized CD4 receptor and of reverse transcriptase activity of viruses (31).
Negative_regulation (inhibition) of gp120 Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection and immunization
6) Confidence 0.02 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193547 Disease Relevance 0.96 Pain Relevance 0

General Comments

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