INT88318

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 208
Total Number 212
Disease Relevance 189.67
Pain Relevance 31.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
stem cells 8
blood 7
monocyte 6
macrophages 5
T cells 5
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 6221 100.00 Very High Very High Very High
Inflammation 1629 100.00 Very High Very High Very High
rheumatoid arthritis 1297 100.00 Very High Very High Very High
antagonist 1285 100.00 Very High Very High Very High
agonist 500 100.00 Very High Very High Very High
cytokine 401 100.00 Very High Very High Very High
opioid receptor 13 100.00 Very High Very High Very High
mu opioid receptor 10 100.00 Very High Very High Very High
Kinase C 54 99.80 Very High Very High Very High
Leflunomide 216 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 2571 100.00 Very High Very High Very High
INFLAMMATION 1852 100.00 Very High Very High Very High
Rheumatoid Arthritis 1377 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1323 100.00 Very High Very High Very High
Muscular Dystrophy 912 100.00 Very High Very High Very High
Targeted Disruption 232 100.00 Very High Very High Very High
Cancer 16196 99.98 Very High Very High Very High
Ovarian Cancer 2983 99.98 Very High Very High Very High
Colon Cancer 1833 99.86 Very High Very High Very High
Reprotox - General 1 613 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCR4 expression is therefore a general
Gene_expression (expression) of CXCR4
1) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.90 Pain Relevance 0.03
to secondary sites [25], Zeelenberg and colleagues found that CXCR4 expression
Gene_expression (expression) of CXCR4
2) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.11 Pain Relevance 0
Finally, manipulations of CXCR4 expression
Gene_expression (expression) of CXCR4
3) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.65 Pain Relevance 0
had suggested that CXCR4 expression was necessary for the movement of tumor cells
Gene_expression (expression) of CXCR4 associated with cancer
4) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.16 Pain Relevance 0
demonstrate the involvement of hypoxia in the regulation of CXCR4 expression [97].
Gene_expression (expression) of CXCR4 associated with hypoxia
5) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.66 Pain Relevance 0
shown that the level of CXCR4 expression can be linked to tumor progressivity

(tumor grade and lymph node status) and to other prognostic factors such as

Gene_expression (expression) of CXCR4 in lymph node associated with cancer
6) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.00 Pain Relevance 0.03
CXCR4 expression in this context led to
Gene_expression (expression) of CXCR4
7) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.75 Pain Relevance 0.20
CXCR4 expression in 4T1 murine breast carcinoma cells using short hairpin RNA
Gene_expression (expression) of CXCR4 in 4T1 associated with breast cancer
8) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.76 Pain Relevance 0.03
The CXCR4 gene is constitutively expressed, and CXCR4 protein has been
Gene_expression (expressed) of CXCR4
9) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.27 Pain Relevance 0.10
pancreatic cancer cells that did not themselves express CXCR4, probably because
Gene_expression (express) of CXCR4 associated with pancreatic cancer
10) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.61 Pain Relevance 0.09
Cancer cells that express CXCR4 exploit the
Gene_expression (express) of CXCR4 associated with cancer
11) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.04 Pain Relevance 0.04
These studies show the importance of CXCR4 expression in
Gene_expression (expression) of CXCR4
12) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.58 Pain Relevance 0.04
demonstrated the efficacy of strategies designed to reduce CXCR4 expression or
Gene_expression (expression) of CXCR4
13) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.63 Pain Relevance 0.03
Concomitan high expression of CXCR4 and VEGF has been
Gene_expression (expression) of CXCR4
14) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.29 Pain Relevance 0.15
increased CXCR4 mRNA and cell-surface protein expression in several cell types,
Gene_expression (expression) of CXCR4 mRNA
15) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.79 Pain Relevance 0.07
Hypoxia increased CXCR4 mRNA expression in
Gene_expression (expression) of CXCR4 mRNA associated with hypoxia
16) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.85 Pain Relevance 0
analysis, they found that CXCR4 mRNA expression was suppressed by the reintroduction of functional pVHL into
Gene_expression (expression) of CXCR4 mRNA
17) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.75 Pain Relevance 0
speculated that intratumoral hypoxia may lead to increased CXCR4 expression in
Gene_expression (expression) of CXCR4 associated with hypoxia
18) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.85 Pain Relevance 0.03
The involvement of CXCR4 expression in
Gene_expression (expression) of CXCR4
19) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.65 Pain Relevance 0
CXCR4 expression on tumor cells and other cell types.
Gene_expression (expression) of CXCR4 associated with cancer
20) Confidence 0.77 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.55 Pain Relevance 0

General Comments

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