INT88322

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 111
Total Number 113
Disease Relevance 77.36
Pain Relevance 39.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR5) plasma membrane (CCR5) cell-cell signaling (CCR5)
cytoplasm (CCR5) signal transducer activity (CCR5)
Anatomy Link Frequency
macrophages 15
T cells 12
monocytes 8
lymphocytes 5
memory T cells 3
CCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1914 100.00 Very High Very High Very High
Inflammation 969 100.00 Very High Very High Very High
Arthritis 552 100.00 Very High Very High Very High
addiction 363 100.00 Very High Very High Very High
Cannabinoid receptor 9 100.00 Very High Very High Very High
Morphine 118 99.92 Very High Very High Very High
Opioid 99 99.84 Very High Very High Very High
agonist 73 99.80 Very High Very High Very High
narcan 13 99.56 Very High Very High Very High
MU agonist 11 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 3204 100.00 Very High Very High Very High
Infection 1274 100.00 Very High Very High Very High
INFLAMMATION 1019 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 416 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 121 99.62 Very High Very High Very High
Osteogenic Sarcomas 8 99.60 Very High Very High Very High
Adhesions 85 99.58 Very High Very High Very High
Rheumatoid Arthritis 768 99.54 Very High Very High Very High
Anaplastic Astrocytoma 16 99.48 Very High Very High Very High
Recurrence 21 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This enhancement was associated with the up-regulation of expression of CCR5, a primary coreceptor for macrophage-tropic HIV entry into macrophages.
Gene_expression (expression) of CCR5 in macrophages associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.78 Published 2002 Journal J. Infect. Dis. Section Abstract Doc Link 11756991 Disease Relevance 1.06 Pain Relevance 0.69
Functional studies revealed that a combination treatment of cells with morphine, an agonist for mu, and MIP-1beta, a ligand for CCR5, suppresses the inhibitory effect of MIP-1beta and increases the stimulatory effect of morphine on CCR5 expression.
Gene_expression (expression) of CCR5 associated with agonist and morphine
2) Confidence 0.78 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12413885 Disease Relevance 0.05 Pain Relevance 0.56
Morphine sulfate induces the formation and expression of both forms of CCR5 whereas RANTES, MIP-1alpha or MIP-1beta inhibits them.
Gene_expression (expression) of CCR5 associated with morphine
3) Confidence 0.78 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12163044 Disease Relevance 0.23 Pain Relevance 0.17
Methadone, a regimen for the treatment of opioid dependency, was found to induce the expression of CCR5, a co-receptor for human immunodeficiency virus (HIV)/simian form of HIV (SIV) entry, on human CEM x174 lymphocytes.
Gene_expression (expression) of CCR5 in lymphocytes associated with acquired immune deficiency syndrome or hiv infection, methadone and opioid
4) Confidence 0.78 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 12023039 Disease Relevance 0.44 Pain Relevance 0.54
The ability of MNTX to block opioid-induced CCR5 expression and HIV replication at clinically relevant doses may have additional benefit for opioid abusers with HIV infection, or patients with AIDS pain receiving opioids.
Gene_expression (expression) of CCR5 associated with pain, acquired immune deficiency syndrome or hiv infection, opioid and infection
5) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14560041 Disease Relevance 1.78 Pain Relevance 1.59
Furthermore, MNTX abolished morphine-mediated up-regulation of CCR5 receptor expression.
Gene_expression (expression) of CCR5 associated with morphine
6) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14560041 Disease Relevance 1.43 Pain Relevance 1.60
Morphine induces gene expression of CCR5 in human CEMx174 lymphocytes.
Gene_expression (expression) of CCR5 in lymphocytes associated with morphine
7) Confidence 0.78 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10887175 Disease Relevance 0.61 Pain Relevance 0.32
Here we present our findings, which indicate that CEM x174 indeed expresses CCR5 and that the amount of CCR5 is increased in cells pretreated with morphine.
Gene_expression (expresses) of CCR5 associated with morphine
8) Confidence 0.78 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10887175 Disease Relevance 0.63 Pain Relevance 0.41
In searching for an answer, we resorted to a sensitive competitive reverse transcriptase-polymerase chain reaction procedure in an attempt to detect as well as quantify the amount of CCR5 expression.
Gene_expression (expression) of CCR5
9) Confidence 0.78 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10887175 Disease Relevance 0.63 Pain Relevance 0.38
Additionally, MDMs can be infected after differentiation and are more susceptible to new infection in comparison to freshly isolated monocytes due to increased expression of the HIV co-receptor CCR5 [26]; however, this infection is limited, and the production of virus is hindered at many steps which will be discussed.
Gene_expression (expression) of CCR5 in monocytes associated with acquired immune deficiency syndrome or hiv infection and infection
10) Confidence 0.75 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 1.21 Pain Relevance 0.11
CEM×174 cells expressing CCR5 by transfection; generously provided by James Robinson) were used.
Gene_expression (expressing) of CCR5
11) Confidence 0.75 Published 2005 Journal Virol J Section Body Doc Link PMC552328 Disease Relevance 0 Pain Relevance 0
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Gene_expression (expression) of CCR5 in monocyte associated with chemokine, carcinoma and adhesions
12) Confidence 0.75 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.48 Pain Relevance 0.14
Morphine significantly up-regulated CCR5 receptor expression and inhibited the endogenous production of macrophage inflammatory protein-1beta in neonatal MDM.
Gene_expression (expression) of CCR5 in macrophage associated with inflammation and morphine
13) Confidence 0.74 Published 2003 Journal Pediatr. Res. Section Abstract Doc Link 12736382 Disease Relevance 1.43 Pain Relevance 0.86
Thus, morphine, most likely through alteration of beta-chemokines and CCR5 receptor expression, enhances the susceptibility of neonatal MDM to HIV infection, and may have a cofactor role in perinatal HIV transmission and infection.
Gene_expression (expression) of CCR5 in MDM associated with chemokine, acquired immune deficiency syndrome or hiv infection, infection and morphine
14) Confidence 0.74 Published 2003 Journal Pediatr. Res. Section Abstract Doc Link 12736382 Disease Relevance 1.56 Pain Relevance 0.82
, and RANTES (regulated on activation, normal T-cell expressed and secreted), which have been giving standard nomenclature CCL3, CCL4, and CCL5, respectively; CCR5 is expressed on immune cells, including effector and memory T-cells, natural killer cells, and antigen presenting cells (Blanpain et al 1999; Ruffing et al 1998).
Gene_expression (expressed) of CCR5 in natural killer cells
15) Confidence 0.74 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.23 Pain Relevance 0.41
Herein we describe the effects of morphine and/or gp120 on the expression of the genes for the beta-chemokine MIP-1beta and its receptors CCR3 and CCR5 by the U373 cells which are a human brain-derived astrocytoma/glioblastoma cell line.
Gene_expression (expression) of CCR5 in brain associated with anaplastic astrocytoma, chemokine, glioblastoma and morphine
16) Confidence 0.71 Published 2005 Journal Curr. HIV Res. Section Abstract Doc Link 16022659 Disease Relevance 1.44 Pain Relevance 0.92
Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS.
Gene_expression (expression) of CCR5 in macrophage associated with chemokine, inflammation, encephalopathy, acquired immune deficiency syndrome or hiv infection, opioid and infection
17) Confidence 0.71 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 0.78 Pain Relevance 1.29
Treatment of NHAs with morphine suppressed IL-8 and macrophage-inflammatory protein-1beta gene expression, whereas expression of their receptor genes, CCR3 and CCR5, was simultaneously enhanced.
Gene_expression (expression) of CCR5 in macrophage associated with inflammation and morphine
18) Confidence 0.71 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 1.14 Pain Relevance 1.30
We found that CHP100 cells constitutively express both CXCR4 and CCR5 receptors and that stimulation with phorbol 12-myristate 13-acetate down-regulates their expression, thus preventing gp120-induced cell death.
Gene_expression (express) of CCR5 associated with death
19) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 1.33 Pain Relevance 0.30
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR.
Gene_expression (expression) of CCR5 in NHA associated with chemokine and morphine
20) Confidence 0.69 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.87

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