INT88323

Context Info Confidence 0.45 First Reported 2000 Last Reported 2006 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.52 Pain Relevance 0.66

mitochondrion (Pars2) ligase activity (Pars2) cytoplasm (Pars2)

Anatomy Link Frequency joint 1 Pars2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 78 99.00 Inflammatory response 2 97.84 ischemia 2 95.60 Peripheral sensitization 11 86.88 opioid receptor 2 76.32 Inflammation 25 75.00 qutenza 3 71.12 anesthesia 1 64.00 Arthritis 29 50.96 rheumatoid arthritis 2 50.72

Disease Link Frequency Relevance Heat Arthralgia 19 99.24 Brain Injury 1 99.12 INFLAMMATION 34 97.84 Nociception 29 97.08 Disease 4 96.88 Cv General 4 Under Development 1 95.60 Cv Unclassified Under Development 1 94.44 Drug Induced Neurotoxicity 1 93.72 Pain 57 83.12 Injury 10 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We examined the effect of inhibiting PARS on the (a) degree of cerebral injury, (b) process of inflammatory responses, and (c) functional outcomes in a neonatal rat model of focal ischemia.

Spec (examined) Regulation (effect) of PARS associated with inflammatory response, ischemia and brain injury

1) Confidence 0.45 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820212 Disease Relevance 0.63 Pain Relevance 0.25

Thus, the PARs are an exciting new target for investigating joint pain modulation and for the potential development of disease-modifying drugs.

Regulation (target) of PARs in joint associated with pain, arthralgia and disease

2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794504 Disease Relevance 0.89 Pain Relevance 0.42

General Comments

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