INT88323

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.52
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pars2) ligase activity (Pars2) cytoplasm (Pars2)
Anatomy Link Frequency
joint 1
Pars2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 78 99.00 Very High Very High Very High
Inflammatory response 2 97.84 Very High Very High Very High
ischemia 2 95.60 Very High Very High Very High
Peripheral sensitization 11 86.88 High High
opioid receptor 2 76.32 Quite High
Inflammation 25 75.00 Quite High
qutenza 3 71.12 Quite High
anesthesia 1 64.00 Quite High
Arthritis 29 50.96 Quite High
rheumatoid arthritis 2 50.72 Quite High
Disease Link Frequency Relevance Heat
Arthralgia 19 99.24 Very High Very High Very High
Brain Injury 1 99.12 Very High Very High Very High
INFLAMMATION 34 97.84 Very High Very High Very High
Nociception 29 97.08 Very High Very High Very High
Disease 4 96.88 Very High Very High Very High
Cv General 4 Under Development 1 95.60 Very High Very High Very High
Cv Unclassified Under Development 1 94.44 High High
Drug Induced Neurotoxicity 1 93.72 High High
Pain 57 83.12 Quite High
Injury 10 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of inhibiting PARS on the (a) degree of cerebral injury, (b) process of inflammatory responses, and (c) functional outcomes in a neonatal rat model of focal ischemia.
Spec (examined) Regulation (effect) of PARS associated with inflammatory response, ischemia and brain injury
1) Confidence 0.45 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820212 Disease Relevance 0.63 Pain Relevance 0.25
Thus, the PARs are an exciting new target for investigating joint pain modulation and for the potential development of disease-modifying drugs.


Regulation (target) of PARs in joint associated with pain, arthralgia and disease
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794504 Disease Relevance 0.89 Pain Relevance 0.42

General Comments

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