INT88326

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.77
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
brain 1
eosinophils 1
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 121 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
cytokine 375 99.76 Very High Very High Very High
Inflammation 362 99.58 Very High Very High Very High
Antihyperalgesic 5 99.58 Very High Very High Very High
agonist 77 99.52 Very High Very High Very High
Morphine 2 99.52 Very High Very High Very High
antinociception 1 98.40 Very High Very High Very High
Visceral pain 3 97.44 Very High Very High Very High
IPN 4 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 454 99.58 Very High Very High Very High
Nociception 8 99.08 Very High Very High Very High
Targeted Disruption 63 98.20 Very High Very High Very High
Hypersensitivity 30 97.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 97.44 Very High Very High Very High
Inflammatory Pain 10 96.96 Very High Very High Very High
Brain Injury 6 96.96 Very High Very High Very High
Neuropathic Pain 89 96.72 Very High Very High Very High
Epilepsy 30 96.60 Very High Very High Very High
Necrosis 14 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, drugs that block P2X7 directly, or interact with proteins that modulate P2X7 activity, may have the potential to treat a broad range of inflammatory diseases, including pain associated with inflammation.


Negative_regulation (block) of P2X7 associated with pain, inflammation and disease
1) Confidence 0.58 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 1.01 Pain Relevance 0.53
However, oATP is known to have actions at receptors other than P2X7, so it is not possible to unequivocally link the action of oATP with P2X7 inhibition in these studies.
Negative_regulation (inhibition) of P2X7
2) Confidence 0.58 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.98 Pain Relevance 0.62
Firstly, very low concentrations of the calmodulin inhibitor calmidazolium were shown to inhibit the P2X7R ion channel by up to 95% yet did not decrease dye uptake [36].
Negative_regulation (inhibit) of P2X7R
3) Confidence 0.54 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Here we show a loss of the rewarding properties of morphine in mice with a genetic disruption of the substance P receptor.
Negative_regulation (disruption) of P receptor associated with substance p and morphine
4) Confidence 0.51 Published 2000 Journal Nature Section Abstract Doc Link 10821273 Disease Relevance 0.34 Pain Relevance 1.00
This stimulation-dependent expression contrasts with a more recent study which showed functional P2X7R were expressed endogenously on eosinophils and that inhibition of the P2X7R, abrogated agonist (BzATP) induced IL-8 release from eosinophils [108].
Negative_regulation (inhibition) of P2X7R in eosinophils associated with agonist
5) Confidence 0.43 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.03 Pain Relevance 0.30
A potential mechanism of action may be proposed whereby deletion of P2X7 in vivo is sufficient to block processing of mature IL-1?
Negative_regulation (deletion) of P2X7
6) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.55 Pain Relevance 0.24
These data demonstrate that selective blockade of P2X7 receptors in vivo produces significant antinociception in animal models of inflammatory pain and suggest that the antihyperalgesic effects of P2X7 receptor blockade in an inflammatory pain model in mice are mediated by blocking the release of IL-1beta.
Negative_regulation (blockade) of P2X7 associated with antihyperalgesic, antinociception and ipn
7) Confidence 0.42 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19464323 Disease Relevance 0.77 Pain Relevance 0.96
Importantly, this group went on to demonstrate that IL-6 production was also greatly reduced (3-fold reduction) in the P2X7 ????
Negative_regulation (reduced) of P2X7
8) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.34 Pain Relevance 0.16
Interestingly, some studies have also demonstrated that release of the ‘anti-inflammatory–cytokine, IL-10, is impaired in P2X7????
Negative_regulation (impaired) of P2X7 associated with inflammation and cytokine
9) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.82 Pain Relevance 0.55
This study also demonstrated that the levels of cell-free IL-10 are significantly reduced in P2X7 ????
Negative_regulation (reduced) of P2X7
10) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.47 Pain Relevance 0.22
posttranslational processing by LPS-activated human monoctyes [102]; this agent is a potent inhibitor of P2X7 receptor-mediated functions [106, 107].
Negative_regulation (inhibitor) of P2X7 receptor
11) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.11
Likewise, oxidized ATP often is employed as an antagonist of the P2X7 receptor [76], but this agent also acts in a P2 receptor-independent manner [77].
Negative_regulation (antagonist) of P2X7 receptor associated with antagonist
12) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.11 Pain Relevance 0.49
but absence of the P2X7 receptor prevents them from doing so when challenged with ATP [26].
Negative_regulation (absence) of P2X7 receptor
13) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
We previously showed the antihyperalgesic effect of oATP, the inhibitor of the P2X7 receptors for the pro-nociceptive ATP, in experimental inflammation.
Negative_regulation (inhibitor) of P2X7 associated with nociception, antihyperalgesic and inflammation
14) Confidence 0.17 Published 2008 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 18336732 Disease Relevance 1.17 Pain Relevance 0.80
P2 receptor blockade also attenuated Mz-ChA-1 proliferation [117].
Negative_regulation (blockade) of P2 receptor
15) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.50 Pain Relevance 0.15
Moreover, since P2 receptor activation is associated with astrogliosis [80], P2 receptor inhibition would be expected to prevent the formation of an epileptogenic focus after brain injury.
Negative_regulation (inhibition) of P2 receptor in brain associated with brain injury
16) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.42 Pain Relevance 0.11

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