INT8835

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Context Info
Confidence 0.68
First Reported 1989
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 65
Total Number 68
Disease Relevance 32.81
Pain Relevance 38.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
sensory nerve 4
eosinophils 4
mast cells 4
nerve 3
nasal 2
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 859 100.00 Very High Very High Very High
Inflammation 522 100.00 Very High Very High Very High
cytokine 213 100.00 Very High Very High Very High
Neuropeptide 159 100.00 Very High Very High Very High
calcitonin gene related peptide 128 100.00 Very High Very High Very High
Enkephalin 61 100.00 Very High Very High Very High
Calcitonin gene-related peptide 43 100.00 Very High Very High Very High
Serotonin 41 100.00 Very High Very High Very High
rheumatoid arthritis 36 100.00 Very High Very High Very High
trigeminal ganglion 6 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 611 100.00 Very High Very High Very High
Rheumatoid Arthritis 55 100.00 Very High Very High Very High
Urological Neuroanatomy 28 100.00 Very High Very High Very High
Ganglion Cysts 27 99.86 Very High Very High Very High
Neurogenic Inflammation 29 99.84 Very High Very High Very High
Nicotine Addiction 14 99.72 Very High Very High Very High
Pruritus 105 99.70 Very High Very High Very High
Tooth Loss 13 99.70 Very High Very High Very High
Pain 83 99.12 Very High Very High Very High
Arthritis 43 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we created an ambitious project that involves both general practitioners and rheumatologists called ESPERANZA, with the purpose of early detection of SpA.
Localization (detection) of SpA
1) Confidence 0.68 Published 2011 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2999954 Disease Relevance 0.35 Pain Relevance 0.21
Mast cell degranulation products and SP release can contribute to TMJ inflammation.


Localization (release) of SP in Mast cell
2) Confidence 0.61 Published 2001 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 11598571 Disease Relevance 0.08 Pain Relevance 0
The absence of SP+ fibers in the early wounds with SP immunostaining in the epidermis and extracellular matrix suggests that SP may be released from injured nerves and supports neurogenic mediation of inflammation and vasodilitation in early wound repair.
Localization (released) of SP in extracellular matrix associated with inflammation, injury and substance p
3) Confidence 0.58 Published 1996 Journal J Burn Care Rehabil Section Abstract Doc Link 8889861 Disease Relevance 1.37 Pain Relevance 0.71
Capsaicin, a vanillyl fatty acid amide (ingredient of hot pepper), released preformed SP from lymphocytes.
Localization (released) of SP in lymphocytes associated with qutenza and substance p
4) Confidence 0.55 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9655475 Disease Relevance 0 Pain Relevance 0.50
Co-localization of SP and CGRP was observed in a dense intraepithelial and perivascular network of capsaicin-sensitive sensory nerves in the nasal mucosa of different species, including man.
Localization (Co-localization) of SP in sensory nerves associated with qutenza
5) Confidence 0.53 Published 1991 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 1891972 Disease Relevance 0.14 Pain Relevance 0.17
The present study was designed to evaluate the secretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) and its relation to clinical variables in RA, spondyloarthropathy (Spa), and undifferentiated inflammatory arthritis (UIA).
Localization (secretion) of Spa associated with inflammation, rheumatoid arthritis and arthritis
6) Confidence 0.48 Published 2001 Journal Arthritis Res Section Abstract Doc Link PMC30711 Disease Relevance 1.03 Pain Relevance 0.55
In addition, capsaicin, which releases endogenous SP from nerve endings, produced depolarizations of a magnitude similar to formalin in strip preparations, but was without effect in cultured cells.
Localization (releases) of SP in nerve associated with qutenza and substance p
7) Confidence 0.47 Published 2006 Journal Toxicol Ind Health Section Abstract Doc Link 16716036 Disease Relevance 0 Pain Relevance 0.29
It is suggested that formalin may act as an irritant to produce bronchoconstriction that is mediated by the release of endogenous substance P (SP) from peripheral sensory nerve endings.
Localization (release) of SP in sensory nerve associated with substance p
8) Confidence 0.47 Published 2006 Journal Toxicol Ind Health Section Abstract Doc Link 16716036 Disease Relevance 0 Pain Relevance 0.27
Electro-acupuncture can inhibit SP release from the skin and the plasma of rats.
Localization (release) of SP in plasma associated with acupuncture
9) Confidence 0.45 Published 1989 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2483985 Disease Relevance 0.25 Pain Relevance 1.16
The localization of substance P (SP), enkephalin (ENK) and serotonin (5-HT) in the retinae of 12 human embryos/fetuses ranging in age from 6-30 weeks was determined immunohistochemically using the PAP method.
Spec (determined) Localization (localization) of SP in embryos associated with enkephalin, serotonin and substance p
10) Confidence 0.45 Published 1991 Journal J Hirnforsch Section Abstract Doc Link 1725785 Disease Relevance 0.06 Pain Relevance 0.58
Capsaicin, a vanillyl fatty acid amide (ingredient of hot pepper), released SP from TF-1 cells.
Localization (released) of SP in TF-1 associated with qutenza and substance p
11) Confidence 0.43 Published 2000 Journal J. Hematother. Stem Cell Res. Section Abstract Doc Link 10982242 Disease Relevance 0 Pain Relevance 0.53
However, in intact animals DCS provoked a marked SP release in the dorsal horn (190 +/- 92% increase; n = 7; P less than 0.01).
Localization (release) of SP in dorsal horn associated with dorsal horn and substance p
12) Confidence 0.42 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.09 Pain Relevance 0.79
The results obtained indicate that part of the EK-positive innervation of the spinal nucleus may be of ganglionic origin and raise the possibility that EK and SP are co-stored in and co-released from primary afferent terminals, thus adding to the complexity of the sites and ways of interaction between these neuropeptides in the processing of sensory information.
Localization (released) of SP in spinal associated with neuropeptide, enkephalin and substance p
13) Confidence 0.38 Published 1994 Journal Neuroreport Section Abstract Doc Link 7516198 Disease Relevance 0.25 Pain Relevance 0.83
The release of serotonin and SP after DCS may indicate that these substances participate in the mediation of the pain alleviating effect of DCS.
Localization (release) of SP associated with pain, serotonin and substance p
14) Confidence 0.36 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.19 Pain Relevance 0.76
In contrast, no release of SP could be recorded in response to DCS in the decerebrated preparation, although peripheral nociceptive stimulation (pinch) and noxious electric dorsal root stimulation induced an elevation of the SP levels.
Localization (release) of SP in dorsal root associated with nociception and substance p
15) Confidence 0.36 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.21 Pain Relevance 0.93
The present series of experiments was undertaken to investigate whether serotonin and SP are released in the dorsal horn by DCS.
Localization (released) of SP in dorsal horn associated with dorsal horn, serotonin and substance p
16) Confidence 0.36 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.17 Pain Relevance 0.74
Activation of these somadendritically located 5-HT2a receptors facilitates SP release.
Localization (release) of SP
17) Confidence 0.30 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938661 Disease Relevance 0.07 Pain Relevance 0.24
Immunohistochemical evidence is provided for (i) the occurrence of a primary sensory neuronal population immunoreactive to methionine- and leucine-enkephalin (EK) in the human trigeminal ganglion; (ii) colocalization of EK and substance P (SP) in a subpopulation of ganglion neurones and in nerve fibres and terminal-like structures in the human trigeminal spinal nucleus.
Localization (colocalization) of SP in ganglion associated with ganglion cysts, trigeminal ganglion, enkephalin and substance p
18) Confidence 0.29 Published 1994 Journal Neuroreport Section Abstract Doc Link 7516198 Disease Relevance 0.27 Pain Relevance 0.83
These findings suggest that SP released from sensory nerves in response to stimuli may mediate cough and NEP may have a role in modulating SP-induced effects.
Localization (released) of SP in sensory nerves associated with cough and substance p
19) Confidence 0.21 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.80 Pain Relevance 0.67
The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed.
Localization (localization) of SP in epithelium associated with neuropeptide and substance p
20) Confidence 0.21 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.56 Pain Relevance 0.40

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