INT88356

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.72
Pain Relevance 16.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 4
spinal cord 2
spinal cord dorsal horn 2
dorsal horn 2
hippocampus 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 80 100.00 Very High Very High Very High
nMDA receptor 45 100.00 Very High Very High Very High
Glutamate receptor 34 100.00 Very High Very High Very High
Ventral tegmentum 18 100.00 Very High Very High Very High
Eae 8 100.00 Very High Very High Very High
cocaine 7 99.98 Very High Very High Very High
intrathecal 11 99.84 Very High Very High Very High
electroacupuncture 6 99.84 Very High Very High Very High
tolerance 16 99.80 Very High Very High Very High
Dorsal horn 12 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 8 100.00 Very High Very High Very High
Nociception 5 100.00 Very High Very High Very High
Diabetes Mellitus 87 99.96 Very High Very High Very High
Hyperalgesia 6 99.48 Very High Very High Very High
INFLAMMATION 8 99.22 Very High Very High Very High
Pain 8 98.84 Very High Very High Very High
Neuropathic Pain 7 98.00 Very High Very High Very High
Temporomandibular Joint Syndrome 9 93.08 High High
Urological Neuroanatomy 1 88.20 High High
Ganglion Cysts 5 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, RTX treatment significantly attenuated the CCI-induced upregulation of NR1 and pNR1 in spinal laminae I-II and V-VI, but not laminae III-IV as compared with that of vehicle-treated CCI rats.
Negative_regulation (attenuated) of Positive_regulation (upregulation) of NR1 in spinal associated with eae
1) Confidence 0.58 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 1.17 Pain Relevance 1.08
Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma.
Negative_regulation (prevented) of Positive_regulation (upregulation) of NR1 in spinal cord dorsal horn associated with dorsal horn, morphine and spinal cord
2) Confidence 0.51 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.41
AIDA or MPEP co-administered with morphine attenuated morphine induced upregulation of NR1.
Negative_regulation (attenuated) of Positive_regulation (upregulation) of NR1 associated with morphine
3) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.72
However, the intrathecal injection of NMDAR antagonist D-2-amino-5-phosphonopentanoic acid significantly prevented serine phosphorylation of NMDAR NR-1 subunits induced by EA stimulation in the dorsal horn of spinal cord.
Negative_regulation (prevented) of Positive_regulation (induced) of NR-1 in dorsal horn associated with antagonist, dorsal horn, electroacupuncture, spinal cord and intrathecal
4) Confidence 0.43 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.93
IMPLICATIONS: Inhaled xenon suppressed nociceptive behaviors, c-fos expression, and activation of the N-methyl-D-aspartate receptor during the formalin test in rats.
Negative_regulation (suppressed) of Positive_regulation (activation) of N-methyl-D-aspartate receptor associated with nociception and nmda receptor
5) Confidence 0.42 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12401615 Disease Relevance 0.33 Pain Relevance 0.64
Once daily intracisternal injection of an IL-6 antiserum or NF-kappaB inhibitor (PDTC) for 6 days, beginning on day 1 immediately after the CFA injection, prevented both the upregulation of NR1 in the ipsilateral Sp5C and pain behavior.
Negative_regulation (prevented) of Positive_regulation (upregulation) of NR1 associated with pain and nmda receptor
6) Confidence 0.42 Published 2009 Journal Pain Section Abstract Doc Link 19058915 Disease Relevance 1.33 Pain Relevance 1.51
The spinal antinociception by NST is most likely attributable to inhibition of glycine-dependent N-methyl-D-aspartate receptor activation.


Negative_regulation (inhibition) of Positive_regulation (activation) of N-methyl-D-aspartate receptor in spinal
7) Confidence 0.41 Published 2004 Journal Anesthesiology Section Body Doc Link 15329601 Disease Relevance 0.06 Pain Relevance 0
The results indicate that constant high plasma levels of progesterone attenuate inflammatory hyperalgesia by a mechanism involving inhibition of N-methyl-D-aspartate receptor activation at the spinal cord level.
Negative_regulation (inhibition) of Positive_regulation (activation) of N-methyl-D-aspartate receptor in spinal cord associated with hyperalgesia, inflammation, nmda receptor and spinal cord
8) Confidence 0.41 Published 2000 Journal Brain Res. Section Abstract Doc Link 10821931 Disease Relevance 0.71 Pain Relevance 0.80
Co-administration of LY274614 (s.c. at 24 mg/kg/24 h via an osmotic pump) not only attenuated the development of morphine tolerance but also prevented the changes in the NR1 mRNA levels induced by chronic morphine administration.
Negative_regulation (prevented) of Positive_regulation (induced) of NR1 mRNA associated with tolerance and morphine
9) Confidence 0.39 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.09 Pain Relevance 1.82
This NR1 and PKCgamma upregulation was significantly diminished by intrathecal coadministration of morphine with the GR antagonist RU38486 or a GR antisense oligodeoxynucleotide.
Negative_regulation (diminished) of Positive_regulation (upregulation) of NR1 associated with antagonist, morphine and intrathecal
10) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.29
Intrathecal coadministration of morphine with an adenylyl cyclase inhibitor (2',5'-dideoxyadenosine) or a protein kinase A inhibitor (H89) also significantly attenuated morphine-induced NR1 and PKCgamma expression, whereas intrathecal treatment with an adenylyl cyclase activator (forskolin) alone mimicked morphine-induced expression of GR, NR1, and PKCgamma.
Negative_regulation (attenuated) of Positive_regulation (morphine-induced) of NR1 associated with morphine and intrathecal
11) Confidence 0.37 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.44
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Negative_regulation (presented) of Positive_regulation (increase) of NR1 in hippocampus associated with nucleus accumbens, hippocampus and cocaine
12) Confidence 0.35 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.35
In our case, we found that NR1 subunit protein levels were not elevated throughout the complete course of diabetes; NR1 subunit protein levels were downregulated at one week, upregulated at four weeks, and downregulated at 12 weeks.
Negative_regulation (downregulated) of Positive_regulation (upregulated) of NR1 subunit associated with diabetes mellitus
13) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.82 Pain Relevance 0.16
Biochemical traits related to morphine's sensitizing effects were altered by intra-VTA anti-FGF-1 because morphine-induced upregulation of both tyrosine hydroxylase (TH) and N-methyl d-aspartate glutamate receptor 1 (NMDAR1) in the VTA was blocked after anti-FGF-1.
Negative_regulation (blocked) of Positive_regulation (upregulation) of NMDAR1 associated with ventral tegmentum, glutamate receptor and morphine
14) Confidence 0.06 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.06 Pain Relevance 1.20
Biochemical traits related to morphine's sensitizing effects were altered by intra-VTA anti-FGF-1 because morphine-induced upregulation of both tyrosine hydroxylase (TH) and N-methyl d-aspartate glutamate receptor 1 (NMDAR1) in the VTA was blocked after anti-FGF-1.
Negative_regulation (blocked) of Positive_regulation (upregulation) of N-methyl d-aspartate glutamate receptor 1 associated with ventral tegmentum, glutamate receptor and morphine
15) Confidence 0.05 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.06 Pain Relevance 1.20
In direct contrast to control cells, the punctate and diffuse SEP-GluR2 in corticosterone-treated cells showed similar loss of SEP-GluR2 fluorescence kinetics upon NMDAR activation.
Negative_regulation (loss) of Positive_regulation (activation) of NMDAR
16) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.08 Pain Relevance 0.04

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