INT88365

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 6.63
Pain Relevance 12.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
neurons 2
nucleus accumbens 1
spinal nerve 1
blood 1
brain 1
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 67 100.00 Very High Very High Very High
Cannabinoid 66 100.00 Very High Very High Very High
Analgesic 65 100.00 Very High Very High Very High
agonist 27 99.96 Very High Very High Very High
Neuropathic pain 93 99.84 Very High Very High Very High
cINOD 16 99.80 Very High Very High Very High
Cannabinoid receptor 11 99.80 Very High Very High Very High
Spinal nerve ligature 2 99.48 Very High Very High Very High
imagery 3 99.22 Very High Very High Very High
Inflammation 86 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 126 99.84 Very High Very High Very High
INFLAMMATION 78 99.52 Very High Very High Very High
Nociception 64 97.76 Very High Very High Very High
Pain 172 96.96 Very High Very High Very High
Increased Venous Pressure Under Development 6 96.76 Very High Very High Very High
Anxiety Disorder 61 95.76 Very High Very High Very High
Ganglion Cysts 11 95.76 Very High Very High Very High
Inflammatory Pain 29 94.36 High High
Urological Neuroanatomy 134 86.32 High High
Fever 30 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat.
Regulation (Effects) of fatty acid amide hydrolase associated with dopamine and analgesic
1) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17336288 Disease Relevance 0 Pain Relevance 0.31
Electrophysiological studies were performed 14-18 d after spinal nerve ligation or sham surgery, and the effects of the FAAH inhibitor cyclohexylcarbamic acid 3-carbamoyl biphenyl-3-yl ester (URB597) on mechanically evoked responses of spinal neurons and levels of endocannabinoids were determined.
Regulation (effects) of FAAH in spinal nerve associated with endocannabinoid and spinal nerve ligature
2) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17182782 Disease Relevance 0.43 Pain Relevance 0.98
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit fatty acid amidohydrolase (FAAH), the enzyme responsible for the metabolism of anandamide, an endocannabinoid.
Regulation (responsible) of FAAH associated with endocannabinoid, inflammation and cinod
3) Confidence 0.45 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16442133 Disease Relevance 0.39 Pain Relevance 0.66
Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors.
Regulation (Effects) of fatty acid amide hydrolase in nucleus accumbens associated with ventral tegmentum, nucleus accumbens, nicotine, morphine and cocaine
4) Confidence 0.45 Published 2010 Journal Addict Biol Section Title Doc Link 20477753 Disease Relevance 0.07 Pain Relevance 1.04
NAGly is a potent inhibitor of the fatty acid amide hydrolase (FAAH), the enzyme primarily responsible for the degradation of the endocannabinoid N-arachidonoyl-ethanolamine (anandamide), and was shown recently to elevate the blood levels of the this analgesic compound.
Regulation (responsible) of FAAH in blood associated with endocannabinoid and analgesic
5) Confidence 0.44 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14715265 Disease Relevance 0 Pain Relevance 0.27
Inhibitors of the enzyme fatty acid amide hydrolase (FAAH), the principal enzyme involved in the metabolism of the endogenous cannabinoid anandamide, have potential utility in the treatment of disorders including inflammation and inflammatory pain.
Regulation (involved) of FAAH associated with inflammation, ipn and cannabinoid
6) Confidence 0.44 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16997568 Disease Relevance 0.19 Pain Relevance 0.23
Inhibitors of the enzyme fatty acid amide hydrolase (FAAH), the principal enzyme involved in the metabolism of the endogenous cannabinoid anandamide, have potential utility in the treatment of disorders including inflammation and inflammatory pain.
Regulation (involved) of fatty acid amide hydrolase associated with inflammation, ipn and cannabinoid
7) Confidence 0.44 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16997568 Disease Relevance 0.19 Pain Relevance 0.23
Calcium-imaging studies were performed to compare the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597 (1 microm) vs. the anandamide (AEA) uptake inhibitor UCM707 (1 microm) on capsaicin (100 nm) and N-arachidonoyl dopamine (NADA; 1 microm)-evoked changes in intracellular calcium [Ca(2+)](i) in DRG neurons.
Regulation (effects) of FAAH in neurons associated with dorsal root ganglion, dopamine, qutenza and imagery
8) Confidence 0.43 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17229097 Disease Relevance 0.35 Pain Relevance 0.67
Calcium-imaging studies were performed to compare the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597 (1 microm) vs. the anandamide (AEA) uptake inhibitor UCM707 (1 microm) on capsaicin (100 nm) and N-arachidonoyl dopamine (NADA; 1 microm)-evoked changes in intracellular calcium [Ca(2+)](i) in DRG neurons.
Regulation (effects) of fatty acid amide hydrolase in neurons associated with dorsal root ganglion, dopamine, qutenza and imagery
9) Confidence 0.43 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17229097 Disease Relevance 0.35 Pain Relevance 0.67
We determined whether prenatal exposure to WIN 55,212-2, a potent cannabinoid receptor agonist, affected (1) density, affinity and/or function of cannabinoid CB(1) receptors, (2) endogenous levels of the endocannabinoid anandamide, (3) activities of the major anandamide synthesising and hydrolysing enzymes, N-acyl-phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), respectively, in brain areas of adult male offspring rats.
Regulation (affected) of FAAH in brain associated with endocannabinoid, cannabinoid receptor, cannabinoid and agonist
10) Confidence 0.42 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644084 Disease Relevance 0 Pain Relevance 0.50
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit fatty-acid amide hydrolase (FAAH), the enzyme responsible for the metabolism of anandamide, an endocannabinoid.
Regulation (responsible) of fatty-acid amide hydrolase associated with endocannabinoid, inflammation and cinod
11) Confidence 0.36 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17027744 Disease Relevance 0.24 Pain Relevance 0.67
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit fatty-acid amide hydrolase (FAAH), the enzyme responsible for the metabolism of anandamide, an endocannabinoid.
Regulation (responsible) of FAAH associated with endocannabinoid, inflammation and cinod
12) Confidence 0.36 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17027744 Disease Relevance 0.24 Pain Relevance 0.67
The four cannabinoid system proteins, including the CB(1) and CB(2) receptors, fatty acid amide hydrolase, and the anandamide transporter, are excellent targets for the development of novel medications for various conditions, including pain, immunosuppression, peripheral vascular disease, appetite enhancement or suppression, and motor disorders.
Regulation (targets) of fatty acid amide hydrolase associated with pain, cannabinoid and increased venous pressure under development
13) Confidence 0.34 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12182958 Disease Relevance 0.35 Pain Relevance 0.34
The activity of anandamide amidohydrolase in hind-paw skin also did not change after treatment with formalin.
Neg (not) Regulation (change) of anandamide amidohydrolase in skin
14) Confidence 0.32 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10822060 Disease Relevance 0.49 Pain Relevance 0.88
putative protein responsible for internalization of AEA and the enzyme FAAH,
Regulation (responsible) of FAAH
15) Confidence 0.31 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.81 Pain Relevance 0.44
However, an increased sensitivity of FAAH activity to inhibition by (R)-ibuprofen as well as (R,S)-flurbiprofen and (S)-flurbiprofen was seen at a lower pH(e).
Regulation (sensitivity) of FAAH
16) Confidence 0.27 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12644895 Disease Relevance 0.14 Pain Relevance 0
Therefore by simultaneously targeting FAAH enzyme and TRPV1 receptors, two different targets controlling nociception in distinct ways, this hybrid molecule could represent an alternative approach to be used in the treatment of neuropathic pain.
Regulation (targeting) of FAAH enzyme associated with nociception and neuropathic pain
17) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.85 Pain Relevance 0.94
The inhibition of the metabolism of endocannabinoids by blocking the enzyme fatty acid amide hydrolase, FAAH, proved to be effective in neuropathic pain [98].
Regulation (effective) of FAAH associated with endocannabinoid and neuropathic pain
18) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.52 Pain Relevance 1.14
The synthesis of anandamide is regulated by the phospholipase D, while another intracellular enzyme, the Fatty Acid Amide Hydrolase (FAAH) is responsible of its degradation, followed by the reassumption of its constituents in phospholipids [31].
Regulation (responsible) of Fatty Acid Amide Hydrolase
19) Confidence 0.13 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 0.48 Pain Relevance 0.74
The inhibition of the metabolism of endocannabinoids by blocking the enzyme fatty acid amide hydrolase, FAAH, proved to be effective in neuropathic pain [98].
Regulation (effective) of fatty acid amide hydrolase associated with endocannabinoid and neuropathic pain
20) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.53 Pain Relevance 1.15

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