INT8837

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 59
Total Number 63
Disease Relevance 21.94
Pain Relevance 35.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
smooth muscle 4
nerve 4
neurons 3
nasal 2
peripheral nervous systems 2
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 267 100.00 Very High Very High Very High
Pain 183 100.00 Very High Very High Very High
qutenza 107 100.00 Very High Very High Very High
Neuropeptide 93 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
Calcitonin gene-related peptide 37 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
Serotonin 18 100.00 Very High Very High Very High
nMDA receptor 18 100.00 Very High Very High Very High
Central nervous system 17 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 38 100.00 Very High Very High Very High
Pain 169 99.98 Very High Very High Very High
Headache 4 99.84 Very High Very High Very High
Asthma 51 99.72 Very High Very High Very High
INFLAMMATION 125 99.58 Very High Very High Very High
Li-fraumeni Syndrome 24 99.42 Very High Very High Very High
Hyperalgesia 22 99.38 Very High Very High Very High
Bronchospasm 10 99.12 Very High Very High Very High
Pressure And Volume Under Development 3 99.10 Very High Very High Very High
Infection 26 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of neurokinin receptors contributes to the excitation of many dorsal horn neurons by cutaneous sensory stimuli, particularly noxious stimuli.
Positive_regulation (Activation) of neurokinin in dorsal horn associated with dorsal horn neuron
1) Confidence 0.67 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7823080 Disease Relevance 0 Pain Relevance 0.45
Tachykinins mediate a variety of physiological processes in the gastrointestinal, pulmonary and genito-urinary tract mainly through the stimulation of NK1 and NK2 receptors.
Positive_regulation (stimulation) of NK2
2) Confidence 0.67 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11049734 Disease Relevance 0.28 Pain Relevance 0.14
Experimental tooth pain elevates substance P and matrix metalloproteinase-8 levels in human gingival crevice fluid.
Positive_regulation (elevates) of substance P in tooth associated with pain, metalloproteinase and substance p
3) Confidence 0.67 Published 2008 Journal Acta Odontol. Scand. Section Title Doc Link 18320414 Disease Relevance 0.38 Pain Relevance 0.76
Thus, bronchoconstriction induced by citric acid inhalation in the guinea pig, mainly caused by the tachykinin NK(2) receptor, is counteracted by bronchoprotective NO after activation of bradykinin B(2) and tachykinin NK(1) receptors in airway epithelium.
Neg (NO) Positive_regulation (activation) of tachykinin in epithelium associated with bradykinin
4) Confidence 0.67 Published 2001 Journal Am. J. Med. Section Abstract Doc Link 11749919 Disease Relevance 0.35 Pain Relevance 0.35
We conclude that the cardiac component of the response to somatic nociception involves indirect spinal pathways that most likely excite neurons located in the lateral crescent nucleus of the parabrachial complex via activation of neurokinin 1 receptors.
Positive_regulation (activation) of neurokinin 1 in lateral associated with nociception and parabrachial
5) Confidence 0.67 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15703395 Disease Relevance 0.24 Pain Relevance 0.41
We conclude that spontaneous phasic contractions of human sigmoid circular smooth muscle may be mediated by activation of NK2 receptors, calcium release from intracellular stores, and activation of calmodulin and protein kinase C.
Positive_regulation (activation) of NK2 in smooth muscle associated with kinase c
6) Confidence 0.59 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16554357 Disease Relevance 0.25 Pain Relevance 0.18
Tachykinins have been proposed to play an important role in human respiratory diseases such as bronchial asthma und chronic obstructive diseases (COPD) as they have been shown to have potent effects on the tone of airway smooth muscle, airway secretions, bronchial circulation and on inflammatory and immune cells by activation of the neurokinin-1 (NK-1) and neurokinin-2 (NK-2) receptors.
Positive_regulation (activation) of neurokinin-2 in smooth muscle associated with asthma, pulmonary disease, inflammation, disease and respiratory disease
7) Confidence 0.53 Published 2006 Journal Pneumologie Section Abstract Doc Link 16463247 Disease Relevance 1.39 Pain Relevance 0.50
Consistent with these results, D-Ala-[L-Pro9,Me-Leu8]substance P(7-11) (GR73632), a selective agonist of NK1 receptors and [pro7]-NKB, a selective agonist of NK3 receptors, conferred protection to DA neurons, whereas (Lys3, Gly8-R-gamma-lactam-Leu9)neurokinin A(3-10) (GR64349), which activates specifically NK2 receptors, did not.
Positive_regulation (activates) of NK2 in DA neurons associated with agonist and substance p
8) Confidence 0.49 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16077032 Disease Relevance 0 Pain Relevance 0.58
No cell somata, however, were immunoreactive for enkephalin, substance P, calcitonin gene-related peptide or somatostatin.
Positive_regulation (immunoreactive) of substance P associated with somatostatin, enkephalin, calcitonin gene-related peptide and substance p
9) Confidence 0.49 Published 1996 Journal J. Neurocytol. Section Abstract Doc Link 8699193 Disease Relevance 0.23 Pain Relevance 0.66
Diffusion coefficients for the peptides in SDS micelles, when ranked from largest to smallest, follow a trend where increasing net positive charge results in the smallest diffusion coefficient: Met-enkephalin > neurokinin A > bradykinin > substance P.
Positive_regulation (increasing) of substance P associated with enkephalin, bradykinin and substance p
10) Confidence 0.49 Published 2004 Journal J. Biomol. Struct. Dyn. Section Abstract Doc Link 14692800 Disease Relevance 0 Pain Relevance 0.81
In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis.
Spec (examined) Positive_regulation (capsaicin-induced) of neurokinin A in nasal associated with rhinitis, qutenza, neuropeptide, calcitonin gene-related peptide and substance p
11) Confidence 0.49 Published 1999 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 10547475 Disease Relevance 0.40 Pain Relevance 0.80
MEASUREMENTS OR MAIN RESULTS: Patients were randomized to group 1 (n = 49), group 2 (n = 49), or group 3 (n = 58), and received TAC 1, TAC 2, or TAC 3, respectively.
Positive_regulation (received) of TAC 1
12) Confidence 0.49 Published 1996 Journal Arch Pediatr Adolesc Med Section Body Doc Link 8620226 Disease Relevance 0 Pain Relevance 0
MEASUREMENTS OR MAIN RESULTS: Patients were randomized to group 1 (n = 49), group 2 (n = 49), or group 3 (n = 58), and received TAC 1, TAC 2, or TAC 3, respectively.
Positive_regulation (received) of TAC 2
13) Confidence 0.49 Published 1996 Journal Arch Pediatr Adolesc Med Section Body Doc Link 8620226 Disease Relevance 0 Pain Relevance 0
During comparison of the results it was revealed that premature newborns, with hypoxemic-ischemic lesion of CNS, treated based on traditional allopathic therapy from the first day of life, manifest significantly high level of neurokinin A and substance P, maintained until the end of first month of life.
Positive_regulation (level) of neurokinin A associated with substance p
14) Confidence 0.49 Published 2009 Journal Georgian Med News Section Abstract Doc Link 19430045 Disease Relevance 0.38 Pain Relevance 0.81
It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.
Spec (possible) Positive_regulation (role) of neurokinin A associated with nociception and migraine
15) Confidence 0.49 Published 1989 Journal Peptides Section Abstract Doc Link 2558365 Disease Relevance 0.20 Pain Relevance 0.10
This is complementary to a second proposal that other cases of chronic pain may be due to a supersensitivity of substance P receptors.
Positive_regulation (supersensitivity) of substance P associated with lasting pain and substance p
16) Confidence 0.49 Published 1982 Journal Pain Section Abstract Doc Link 6184663 Disease Relevance 0.60 Pain Relevance 1.32
Tachykinins have been proposed to play an important role in human respiratory diseases such as bronchial asthma und chronic obstructive diseases (COPD) as they have been shown to have potent effects on the tone of airway smooth muscle, airway secretions, bronchial circulation and on inflammatory and immune cells by activation of the neurokinin-1 (NK-1) and neurokinin-2 (NK-2) receptors.
Positive_regulation (activation) of NK-2 in smooth muscle associated with asthma, pulmonary disease, inflammation, disease and respiratory disease
17) Confidence 0.46 Published 2006 Journal Pneumologie Section Abstract Doc Link 16463247 Disease Relevance 1.40 Pain Relevance 0.50
Results showed that indomethacin significantly reduced nociception-related peripheral edema, hyperalgesia, and reversed the pain-evoked up-regulation of neurokinin (NK)-1 receptor and brain-derived neurotrophic factor (BDNF) gene expression in the spinal cord to levels not statistically different from controls.
Positive_regulation (up-regulation) of neurokinin in spinal cord associated with nociception, pain, pressure and volume under development, hyperalgesia and spinal cord
18) Confidence 0.45 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.44 Pain Relevance 1.44
BACKGROUND: Animal studies suggest that substance P, a peptide that preferentially activates the neurokinin-1 (NK1) receptor, is involved in pain transmission, with particular importance in pain after inflammation.
Positive_regulation (activates) of neurokinin-1 associated with pain, inflammation and substance p
19) Confidence 0.45 Published 1998 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9834049 Disease Relevance 0.37 Pain Relevance 0.44
This TRPV1 releases the substance P, which in turn activates the postsynaptic receptor of substance P, neurokinin-1.
Positive_regulation (activates) of substance P associated with substance p
20) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2912905 Disease Relevance 0.14 Pain Relevance 0.21

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