INT88396

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.93
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES1)
Anatomy Link Frequency
spine 1
ganglion 1
CES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cervicogenic headache 11 100.00 Very High Very High Very High
Pain 2 91.08 High High
headache 4 89.60 High High
Migraine 1 67.52 Quite High
alcohol 14 10.84 Low Low
cocaine 4 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Post-traumatic Headache 11 100.00 Very High Very High Very High
Pain 2 91.08 High High
Headache 4 89.60 High High
Cancer 48 88.24 High High
Chronic Disease 52 87.64 High High
Coronary Artery Disease 66 79.52 Quite High
Death 24 77.92 Quite High
Musculoskeletal Disease 2 77.56 Quite High
Chronic Renal Failure 2 75.80 Quite High
Liver Disease 2 74.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human CES1 amino acid sequence was used for BLAT interrogation of the opossum genome, generating an opossum CES1 homologue gene and a predicted amino acid sequence for this enzyme.
Positive_regulation (used) of CES1
1) Confidence 0.49 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Protein sequences were generated in silico for opossum CES genes using the UC Santa Cruz Genome Browser [38,39] and human CES1, CES2 and CES6 sequences in BLAT analyses of the opossum genome.
Spec (analyses) Positive_regulation (generated) of CES1
2) Confidence 0.49 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The human CES1 amino acid sequence was used for BLAT interrogation of the opossum genome, generating an opossum CES1 homologue gene and a predicted amino acid sequence for this enzyme.
Positive_regulation (generating) of CES1
3) Confidence 0.49 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The following UniProtKB/Swiss-Prot Database sequences were used to interrogate the opossum genome sequence [38]: human sequences CES1 (P23141), CES2 (O00748), CES3 (Q6UWW8), CES4 (Q8TDZ9); CES6 (Q6UX55) and CES7 (Q96DN9) (Table 1); as well as the opossum CES2 sequence reported in this paper.
Positive_regulation (sequences) of CES1
4) Confidence 0.43 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Our findings are consistent with published evidence showing a gradient in health across neighbourhoods, however it remains unclear whether our findings are attributable to community versus individual SES, as the former could simply be acting as a proxy measure for variations in the latter.
Positive_regulation (attributable) of SES
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 0.60 Pain Relevance 0
For each SES category, patients were placed in one of five quintiles, according to their neighbourhood's standing relative to the 469 neighbourhoods in the province of British Columbia.
Positive_regulation (placed) of SES
6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 1.09 Pain Relevance 0
In most cases, CEH is caused by pathology in the upper aspect of the cervical spine, but the type and exact location of the pathology varies substantially among individual cases.
Positive_regulation (caused) of CEH in spine associated with cervicogenic headache
7) Confidence 0.39 Published 2006 Journal J Headache Pain Section Abstract Doc Link 16575502 Disease Relevance 1.23 Pain Relevance 1.29
RESULTS: CEH can be triggered by vascular or scar tissue compression of the C2 root and ganglion and irritation of other upper cervical nerve roots (C3, C4).
Positive_regulation (triggered) of CEH in ganglion
8) Confidence 0.21 Published 2000 Journal Clin. Exp. Rheumatol. Section Body Doc Link 10824291 Disease Relevance 0 Pain Relevance 0

General Comments

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