INT8840

Context Info Confidence 0.50 First Reported 1992 Last Reported 2011 Negated 1 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 1.80 Pain Relevance 2.74

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA) nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)

Anatomy Link Frequency eyes 2 nerves 2 peptidergic neurons 2 CALCA (Homo sapiens)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 212 100.00 substance P 35 100.00 Neuropeptide 55 98.04 nociceptor 4 95.36 anesthesia 4 93.60 qutenza 2 92.44 Nerve growth factor 1 91.44 ergotamine 2 88.60 Sumatriptan 3 88.00 antagonist 14 84.96

Disease Link Frequency Relevance Heat Opiate Addiction 2 99.68 Increased Venous Pressure Under Development 12 91.84 Natriuresis 2 91.16 Pressure And Volume Under Development 1 89.08 Cluster Headache 3 87.28 Conjunctiva Disease 10 85.76 Hypersensitivity 38 82.56 Nociception 1 75.00 Conjunctivitis 4 72.00 Disease 8 57.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that CGRP, but not NO, released from non-adrenergic non-cholinergic nerves by electrical stimulation produces relaxation of canine lingual artery that is mediated by activation of CGRP1 receptors.

Positive_regulation (mediated) of Positive_regulation (activation) of CGRP1 in nerves associated with calcitonin gene-related peptide

1) Confidence 0.50 Published 1995 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7544421 Disease Relevance 0 Pain Relevance 0.48

Finally, using RT-PCR, we could demonstrate the presence of mRNAs encoding for several 5-HT receptors (5-HT(1B), 5-HT(1D), 5-HT(1F), 5-HT(2A) and 5-HT(7)) and adrenoceptors (alpha(1A), alpha(1B), alpha(1D), alpha(2A), alpha(2B), alpha(2C), beta(1) and beta(2)), as well as that for the calcitonin receptor like receptor, a component of the CGRP(1) receptor.

Positive_regulation (demonstrate) of Positive_regulation (component) of CGRP

2) Confidence 0.49 Published 2006 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17103145 Disease Relevance 0.36 Pain Relevance 0.55

We provide in vivo evidence that a population of peptidergic neurons, derived from the RUNX1 lineage, require Met activity for the proper extinction of Runx1 and optimal activation of CGRP (calcitonin gene-related peptide).

Positive_regulation (activity) of Positive_regulation (activation) of CGRP in peptidergic neurons associated with calcitonin gene-related peptide

3) Confidence 0.49 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20844136 Disease Relevance 0.07 Pain Relevance 0.26

One antiserum substantially confirmed the previous findings of increased levels of calcitonin during heroin use, but the other seemed to exclude any change in the hormone concentrations.

Positive_regulation (levels) of Positive_regulation (increased) of calcitonin associated with opiate addiction

4) Confidence 0.47 Published 1992 Journal Int. J. Legal Med. Section Abstract Doc Link 1381213 Disease Relevance 0.10 Pain Relevance 0

One antiserum substantially confirmed the previous findings of increased levels of calcitonin during heroin use, but the other seemed to exclude any change in the hormone concentrations.

Positive_regulation (increased) of Positive_regulation (levels) of calcitonin associated with opiate addiction

5) Confidence 0.47 Published 1992 Journal Int. J. Legal Med. Section Abstract Doc Link 1381213 Disease Relevance 0.10 Pain Relevance 0

These results are consistent with previous structure-function investigations of the neuropeptide and are the first to propose specific CLR binding contacts for the amidated F37 of CGRP that are important for docking but not activation of the mature CGRP receptor.

Positive_regulation (important) of Neg (not) Positive_regulation (activation) of CGRP associated with neuropeptide and calcitonin gene-related peptide

6) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.50

A 3-fold increase compared with control in CGRP occurred 30 min after initiation of CPB.

Positive_regulation (occurred) of Positive_regulation (increase) of CGRP associated with calcitonin gene-related peptide

7) Confidence 0.41 Published 1995 Journal Masui Section Abstract Doc Link 8523650 Disease Relevance 0.26 Pain Relevance 0.64

However, using a “paired Wilcoxon Rank test” for statistical analysis –which analyses the magnitude of the difference in paired samples– allowed us to convincingly demonstrate the increase of SP, CGRP and VIP tear levels after CPT only in eyes challenged with allergen.

Positive_regulation (increase) of Positive_regulation (increase) of CGRP in eyes associated with substance p

8) Confidence 0.26 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.91 Pain Relevance 0.32

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