INT8841

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Context Info
Confidence 0.34
First Reported 1985
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 2.27
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ICT1)
Anatomy Link Frequency
blood 1
ICT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 98.12 Very High Very High Very High
Inflammation 30 91.44 High High
Inflammatory response 3 61.88 Quite High
opiate 1 25.00 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypophosphatemia 1 98.70 Very High Very High Very High
Pain 1 98.12 Very High Very High Very High
Muscle Disease 7 97.84 Very High Very High Very High
Hypocalcemia 12 93.84 High High
Disease 8 93.80 High High
INFLAMMATION 36 91.44 High High
Rickets 4 90.96 High High
Infection 3 90.12 High High
Peritonitis 6 89.56 High High
Heat Stroke 3 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both presented with myopathy and bone pain, and showed hypophosphatemia, hyperglycinuria, reduced tubular phosphate reabsorption (TPR), increased hydroxyprolinuria and normal iPTH and iCT values.
Positive_regulation (increased) of iCT associated with pain, hypophosphatemia and muscle disease
1) Confidence 0.34 Published 1985 Journal Clin. Rheumatol. Section Abstract Doc Link 3840730 Disease Relevance 0.91 Pain Relevance 0.10
High levels of immunoreactive calcitonin (iCT) in the blood of heroin addicts were previously reported.
Positive_regulation (levels) of iCT in blood
2) Confidence 0.20 Published 1992 Journal Int. J. Legal Med. Section Abstract Doc Link 1381213 Disease Relevance 0 Pain Relevance 0
Serum total iCT levels among groups exposed to a high dose of E

coli (n = 13–15) and killed at 3, 6, 12 and 24 h increased from a baseline of 21 ± 2 pg/ml (mean ± SEM) to 78 ± 3, 542 ± 100, 3570 ± 920, and 4240 ± 1080 pg/ml, respectively.

Positive_regulation (increased) of iCT
3) Confidence 0.06 Published 1999 Journal Crit Care Section Body Doc Link PMC29007 Disease Relevance 0.06 Pain Relevance 0
Using an antiserum to CT which recognizes the free mature

CT, the immature CT within the ProCT molecule, and the conjoined CT:CCP-1 peptide, we have demonstrated that levels of serum total iCT are also elevated in the septic hamster.

Positive_regulation (elevated) of iCT
4) Confidence 0.06 Published 1999 Journal Crit Care Section Body Doc Link PMC29007 Disease Relevance 0.88 Pain Relevance 0.08
Incremental increases in doses of bacteria resulted in

proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml).

Positive_regulation (increases) of iCT
5) Confidence 0.06 Published 1999 Journal Crit Care Section Abstract Doc Link PMC29007 Disease Relevance 0.42 Pain Relevance 0

General Comments

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