INT88410

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) anatomical structure formation involved in morphogenesis (BMP7)
cytoplasm (CDK2) cytosol (CDK2) mitosis (CDK2)
Anatomy Link Frequency
SMCs 2
BMP7 (Homo sapiens)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 70.88 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies on the mechanism of action indicate that BMP-7 treatment inhibits cyclin-dependent kinase 2 (cdk-2) that was stimulated during PDGF-BB-induced proliferation of SMCs and upregulates the expression of the inhibitory Smad, Smad6, which was shown to inhibit TGF-beta superfamily signaling.
BMP-7 Negative_regulation (inhibits) of cdk-2 in SMCs
1) Confidence 0.35 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0.07
Studies on the mechanism of action indicate that BMP-7 treatment inhibits cyclin-dependent kinase 2 (cdk-2) that was stimulated during PDGF-BB-induced proliferation of SMCs and upregulates the expression of the inhibitory Smad, Smad6, which was shown to inhibit TGF-beta superfamily signaling.
BMP-7 Negative_regulation (inhibits) of cyclin-dependent kinase 2 in SMCs
2) Confidence 0.35 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0.07

General Comments

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