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Context Info
Confidence 0.11
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) embryo development (PDGFA)
cytoplasm (CDK2) cell-cell signaling (PDGFA) cytosol (CDK2)
Anatomy Link Frequency
SMCs 2
PDGFA (Homo sapiens)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 74.40 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies on the mechanism of action indicate that BMP-7 treatment inhibits cyclin-dependent kinase 2 (cdk-2) that was stimulated during PDGF-BB-induced proliferation of SMCs and upregulates the expression of the inhibitory Smad, Smad6, which was shown to inhibit TGF-beta superfamily signaling.
Positive_regulation (stimulated) of PDGF-BB Positive_regulation (induced) of cdk-2 in SMCs
1) Confidence 0.11 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0.07

General Comments

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