INT88414

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 18.40
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
Anatomy Link Frequency
SMCs 2
HT-29 1
HL-60 1
BxPC-3 1
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 49 100.00 Very High Very High Very High
cINOD 22 99.80 Very High Very High Very High
qutenza 139 99.56 Very High Very High Very High
Taxol 2 80.76 Quite High
Enkephalin 13 77.00 Quite High
corticosteroid 9 75.60 Quite High
Opioid 80 75.40 Quite High
narcan 55 75.36 Quite High
palliative 3 70.88 Quite High
antagonist 142 67.28 Quite High
Disease Link Frequency Relevance Heat
Retinoblastoma 161 99.44 Very High Very High Very High
Acantholysis 195 99.20 Very High Very High Very High
Bullous Skin Disease 912 99.08 Very High Very High Very High
Ovarian Cancer 18 98.36 Very High Very High Very High
Apoptosis 390 97.92 Very High Very High Very High
Hypoxia 77 96.16 Very High Very High Very High
Hyperlipidemia 3 95.36 Very High Very High Very High
Breast Cancer 139 95.28 Very High Very High Very High
Alagille Syndrome 2 94.80 High High
Reprotox - General 1 9 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin-induced G0/G1-phase arrest involved the suppression of CDK2 and the cyclin E complex, which are check-point enzymes for cells moving from G0/G1- to S-phase.
Negative_regulation (suppression) of CDK2 associated with qutenza
1) Confidence 0.57 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16827131 Disease Relevance 0.64 Pain Relevance 0.72
The cell cycle inhibition occurred concomitantly with an increase in p27(KIP1) protein levels, a reduction in Rb protein phosphorylation on serine residues 807-811, and a significant decrease in cyclin E-associated cdk2 activity.
Negative_regulation (decrease) of cdk2
2) Confidence 0.57 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.55 Pain Relevance 0.06
In parallel to the NSAID-mediated reduction of CDK-2 activity, p21(cip-1) promoter activity and cellular p21(cip-1) levels increased and p21(cip-1) was sequestered into CDK-2 complexes.
Negative_regulation (reduction) of CDK-2 associated with cinod
3) Confidence 0.48 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566837 Disease Relevance 0.38 Pain Relevance 0.60
To examine whether the OGF-induced downregulation of Cdk2 kinase activity was related to a change in cyclin E expression, homogenates of BxPC-3 cells were subjected to Cdk2 immunoprecipitation.
Spec (whether) Negative_regulation (downregulation) of Cdk2 in BxPC-3
4) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.12 Pain Relevance 0
This reduction in Cdk2 kinase activity correlated with an increase in Cdk2/p21 complex formation in the OGF-exposed cells relative to control cultures at all time points.
Negative_regulation (reduction) of Cdk2
5) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.86 Pain Relevance 0
Cdk2 activity was decreased relative to controls at 15, 18, and 21 hours in response to OGF treatment.
Negative_regulation (decreased) of Cdk2
6) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.77 Pain Relevance 0
Because p21 inhibits Cdk2 by physical interaction, we examined whether the OGF-induced downregulation of Cdk2 kinase activity was based on p21/Cdk2 complex formation.
Negative_regulation (downregulation) of Cdk2
7) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0.21
Elevated levels of CCNG2, cyclin B1 interacting protein 1 (CCNB1IP1), forkhead box O3A (FOXO3A), GADD45A and p21cip1 genes as well as downregulation of cyclin A2 (CCNA2) and CDK2 provided evidence that cell cycle progression might be additionally arrested at the G2/M-checkpoint.
Negative_regulation (downregulation) of CDK2
8) Confidence 0.36 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.05 Pain Relevance 0
Thus, the G1 arrest likely resulted from p21(cip-1)-dependent inhibition of CDK-2 activity.
Negative_regulation (inhibition) of CDK-2
9) Confidence 0.35 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566837 Disease Relevance 0.36 Pain Relevance 0.59
Our observation that OGF down-regulated the phosphorylation of Rb on S795 is consistent with decreased Cdk2 kinase activity.
Negative_regulation (decreased) of Cdk2 associated with retinoblastoma
10) Confidence 0.35 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.83 Pain Relevance 0
These results demonstrate that the OGF-mediated decrease of pRb was consistent with the reduction in Cdk2 kinase activities.


Negative_regulation (reduction) of Cdk2
11) Confidence 0.34 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.18 Pain Relevance 0
This change was correlated with reduced Cdk4, but not Cdk2, kinase activity.
Negative_regulation (reduced) of Cdk2
12) Confidence 0.34 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.24 Pain Relevance 0.27
CDK2 and CDK4 protein levels were reduced after ALA treatment at physiological concentrations.



Negative_regulation (reduced) of CDK2
13) Confidence 0.33 Published 2002 Journal BMC Cancer Section Abstract Doc Link PMC101407 Disease Relevance 0.47 Pain Relevance 0
In our experiments, CDK2 and CDK4 protein levels decreased with ALA treatment preventing cells proliferation.
Negative_regulation (decreased) of CDK2
14) Confidence 0.33 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.60 Pain Relevance 0
The potentiation of the inhibitory effect of 5-FU by CQ was dependent on the increase of p21Cip1 and p27Kip1 and the decrease of CDK2.
Negative_regulation (decrease) of CDK2
15) Confidence 0.32 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2914703 Disease Relevance 0.83 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of CDK2
16) Confidence 0.32 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
The G0/G1 arrest of HT-29 cells induced by 5-FU and potentiated by CQ was dependent on the increase of p21Cip1and p27Kip1, and decrease of CDK2
Negative_regulation (decrease) of CDK2 in HT-29
17) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.05 Pain Relevance 0
Studies on the mechanism of action indicate that BMP-7 treatment inhibits cyclin-dependent kinase 2 (cdk-2) that was stimulated during PDGF-BB-induced proliferation of SMCs and upregulates the expression of the inhibitory Smad, Smad6, which was shown to inhibit TGF-beta superfamily signaling.
Negative_regulation (inhibits) of cdk-2 in SMCs
18) Confidence 0.30 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0.07
Studies on the mechanism of action indicate that BMP-7 treatment inhibits cyclin-dependent kinase 2 (cdk-2) that was stimulated during PDGF-BB-induced proliferation of SMCs and upregulates the expression of the inhibitory Smad, Smad6, which was shown to inhibit TGF-beta superfamily signaling.
Negative_regulation (inhibits) of cyclin-dependent kinase 2 in SMCs
19) Confidence 0.30 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0.07
This was associated with downregulation of the levels of cyclins D1 and B1, and with inhibition of CDK1, CDK2 and CDK4.
Negative_regulation (inhibition) of CDK2
20) Confidence 0.29 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.63 Pain Relevance 0.07

General Comments

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