INT88415

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 5.26
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (DYM) cytoplasm (DYM)
Anatomy Link Frequency
Blood vessels 2
visceral 1
uterine smooth muscle 1
SMCs 1
DYM (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 96.40 Very High Very High Very High
Potency 3 86.92 High High
chemokine 22 83.80 Quite High
Inflammation 44 80.52 Quite High
agonist 25 77.04 Quite High
antagonist 13 76.16 Quite High
Inflammatory response 33 57.16 Quite High
Dismenorea 12 25.00 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
Neuropeptide 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 22 99.92 Very High Very High Very High
Hypoxia 209 99.10 Very High Very High Very High
Congenital Anomalies 55 99.02 Very High Very High Very High
Syndrome 22 98.32 Very High Very High Very High
Cancer 396 97.04 Very High Very High Very High
Vascular System Injuries 88 96.56 Very High Very High Very High
Microphthalmia 11 96.32 Very High Very High Very High
Marfan Syndrome 22 91.52 High High
Neuroblastoma 1 91.04 High High
Asthma 33 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results collectively suggest that BMP-7 maintains the expression of vascular SMC phenotype and may prevent vascular proliferative disorders, thus potentially acting as a palliative after damage to the vascular integrity.
Gene_expression (expression) of SMC associated with palliative
1) Confidence 0.58 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0.10
Several biological themes emerged in our analysis of SMC gene expression.
Gene_expression (expression) of SMC gene
2) Confidence 0.27 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.06 Pain Relevance 0
Disruption of the PBX1 gene in mice leads to a general hypotrophy of many visceral organs, yet no vascular abnormalities are noted [40], in accordance with its visceral SMC-specific expression.
Gene_expression (expression) of SMC-specific in visceral associated with congenital anomalies
3) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.71 Pain Relevance 0
Blood vessels in tumors are often abnormal—they can be greatly enlarged, tortuous, and “leaky”—and the component SMCs often have abnormal morphology and sometimes fail to express the appropriate SMC differentiation marker genes [18].
Gene_expression (express) of SMC in Blood vessels associated with cancer
4) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.37 Pain Relevance 0
For example, the expression of vascular SMC-specific genes appears to be partially controlled by high TGF-?
Gene_expression (expression) of SMC-specific
5) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0 Pain Relevance 0
signaling pathway by vascular SMCs [75–77] suggests that this feature of the vascular SMC expression program might be maintained via an autocrine mechanism.
Gene_expression (expression) of SMC
6) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0 Pain Relevance 0
can trigger SMC differentiation by activating the expression of many SMC lineage genes [71] through the TGF-?
Gene_expression (expression) of SMC
7) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0 Pain Relevance 0
Expression of the vascular SMC serum-response program in human carcinomas may reflect aberrant properties of the tumor vasculature, which can often have biochemical, structural, and compositional abnormalities that result in defective and leaky endothelial cells.
Gene_expression (Expression) of SMC in vasculature associated with congenital anomalies, cancer and carcinoma
8) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.88 Pain Relevance 0
Mutations in fibrillin 1 lead to Marfan's syndrome, in which major defects affect the vascular structures, in agreement with vascular SMC expression of fibrillin-1 (Figure 2B).
Gene_expression (expression) of SMC associated with syndrome
9) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.95 Pain Relevance 0.03
First, although important common mechanisms for regulating the expression of SMC lineage markers are shared by all SMCs [3], unique differentiation programs characteristic of SMCs at distinct anatomic sites were reflected in the pervasive differences in gene expression patterns.
Gene_expression (expression) of SMC
10) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.05 Pain Relevance 0
As a step toward understanding the intrinsic differences between SMCs from different anatomical locations, we used DNA microarrays to profile global gene expression patterns in 36 SMC samples from various tissues after propagation under defined conditions in cell culture.
Gene_expression (expression) of SMC in SMCs
11) Confidence 0.20 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1994710 Disease Relevance 0.16 Pain Relevance 0
To test whether an expression signature of the hypoxia response was indeed overrepresented in vascular SMCs, we used a previously obtained hypoxia-response gene signature [36] to analyze the SMC expression dataset.
Spec (analyze) Gene_expression (expression) of SMC associated with hypoxia
12) Confidence 0.20 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.84 Pain Relevance 0.08
SAR150640 and SSR500400 also increased cAMP production in membrane preparations from human uterine smooth muscle cells (UtSMC), which also express native beta(3)-adrenoceptors (pEC(50) = 7.7 and 7.7, respectively).
Gene_expression (express) of UtSMC in uterine smooth muscle
13) Confidence 0.01 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17351104 Disease Relevance 0.24 Pain Relevance 0.22

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