INT88416

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACTA1) cytoplasm (ACTA1)
Anatomy Link Frequency
filaments 2
muscle 2
ACTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 121 99.32 Very High Very High Very High
palliative 1 41.52 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Channelopathies 5 99.12 Very High Very High Very High
Muscle Disease 51 97.92 Very High Very High Very High
Hypopituitarism 3 68.80 Quite High
Targeted Disruption 3 58.24 Quite High
Pressure And Volume Under Development 5 51.36 Quite High
Infection 40 42.12 Quite Low
Nemaline Myopathy 1 34.12 Quite Low
Disease 29 24.40 Low Low
Congenital Structural Myopathies 2 12.56 Low Low
Muscular Dystrophy 37 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time the pathogen is released from the phagosome, it induces the expression of ActA, a protein that triggers the nucleation and polymerization of host globular g-actin into f-actin filaments.
Positive_regulation (induces) of Gene_expression (expression) of ActA in filaments
1) Confidence 0.67 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.06 Pain Relevance 0
Typical muscle imaging findings of patients with proven mutations in the DNM2, SEPN1, ACTA1, RYR1 and collagen 6A1 are provided

Muscle channelopathies and metabolic myopathies

Positive_regulation (mutations) of Gene_expression (6A1) of ACTA1 in muscle associated with muscle disease, channelopathies and imagery
2) Confidence 0.35 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2940021 Disease Relevance 1.00 Pain Relevance 0.13
Concomitantly, addition of BMP-7 stimulates the expression of SMC-specific markers, namely alpha-actin and heavy chain myosin as examined by RT-PCR and Northern blot analyses.
Spec (analyses) Positive_regulation (stimulates) of Spec (analyses) Gene_expression (expression) of alpha-actin
3) Confidence 0.08 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0

General Comments

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