INT88425

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 4.68
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DYSF)
Anatomy Link Frequency
erector spinae 1
deltoid 1
muscle 1
DYSF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 98.68 Very High Very High Very High
Inflammatory response 4 97.88 Very High Very High Very High
backache 2 76.72 Quite High
imagery 3 70.48 Quite High
Pain 2 61.24 Quite High
Paracetamol 4 35.28 Quite Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Onset of action 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 10 99.84 Very High Very High Very High
Muscular Dystrophy 28 99.72 Very High Very High Very High
Sprains And Strains 4 98.88 Very High Very High Very High
Muscle Disease 166 98.76 Very High Very High Very High
INFLAMMATION 30 98.68 Very High Very High Very High
Disease 16 98.40 Very High Very High Very High
Necrosis 12 96.48 Very High Very High Very High
Myositis 9 93.36 High High
Polymyositis 11 84.00 Quite High
Low Back Pain 2 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscular dystrophy due to dysferlin deficiency in Libyan Jews.
Negative_regulation (deficiency) of dysferlin associated with frailty
1) Confidence 0.57 Published 2000 Journal Brain Section Title Doc Link 10825360 Disease Relevance 0.36 Pain Relevance 0.06
In the animal model of DYSF deficiency, i.e. the mutant SJL mouse strain, the disease process was initially considered an 'inflammatory' form of muscular dystrophy.
Negative_regulation (deficiency) of DYSF associated with inflammation, muscular dystrophy, disease and sprains and strains
2) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 1.12 Pain Relevance 0.23
Immunostaining and western-blotting showed an absence of DYSF protein.
Negative_regulation (absence) of DYSF
3) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 0.36 Pain Relevance 0
Immunostaining and western-blotting showed an absence of DYSF protein.
Negative_regulation (absence) of DYSF
4) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 0.23 Pain Relevance 0
A chromosomal analysis showed a homozygous deletion of exon 55 (6233del CCTTCAGC) of the DYSF gene.
Negative_regulation (deletion) of DYSF
5) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 0.37 Pain Relevance 0
Overall, this case report shows that the lumbar and lower thoracic of erector spinae muscles may display complete fatty degeneration without the occurrence of camptocormia, with primary dysferlin deficiency as a possible cause.
Spec (possible) Negative_regulation (deficiency) of dysferlin in erector spinae
6) Confidence 0.42 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 17932988 Disease Relevance 0.24 Pain Relevance 0.09
Muscle computed tomography revealed mild fatty degeneration of thigh and gastrocnemius muscles, and histopathology of the deltoid muscle showed dystrophic features and complete lack of dysferlin.
Negative_regulation (lack) of dysferlin in deltoid
7) Confidence 0.42 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 17932988 Disease Relevance 0.26 Pain Relevance 0.11
McNally et al. (13) reported that the presence of inflammation is not an exclusion criterion in muscular dystrophy related to a dysferlin deficiency, while the muscle biopsies of MM or LGMD2B patients generally demonstrates signs of a dystrophy with a dysferlin deficiency.
Negative_regulation (deficiency) of dysferlin in muscle associated with inflammation, muscular dystrophy and muscle disease
8) Confidence 0.42 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729898 Disease Relevance 1.74 Pain Relevance 0.33

General Comments

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