INT88449

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Context Info
Confidence 0.12
First Reported 2000
Last Reported 2000
Negated 7
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) nucleus (Uncx)
Anatomy Link Frequency
hypothalamus 1
pituitary 1
striatum 1
adrenal medulla 1
brainstem 1
Uncx (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 35 98.20 Very High Very High Very High
Hippocampus 7 97.88 Very High Very High Very High
midbrain 7 96.96 Very High Very High Very High
Enkephalin 14 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHX increased proENK and TH mRNA levels in the adrenal gland, but not in hippocampus, striatum, midbrain, brainstem, pituitary, and hypothalamus.
CHX Neg (not) Positive_regulation (increased) of proENK in hippocampus associated with medulla, midbrain and hippocampus
1) Confidence 0.12 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.18
Finally, glucocorticoid seems to be involved at least partially in CHX-dependent proENK, but not TH, mRNA expression in the adrenal medulla.
CHX Neg (not) Positive_regulation (dependent) of proENK in adrenal medulla associated with medulla
2) Confidence 0.10 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.17
CHX increased proENK and TH mRNA levels in the adrenal gland, but not in hippocampus, striatum, midbrain, brainstem, pituitary, and hypothalamus.
CHX Neg (not) Positive_regulation (increased) of proENK in hypothalamus associated with medulla, midbrain and hippocampus
3) Confidence 0.04 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.18
CHX increased proENK and TH mRNA levels in the adrenal gland, but not in hippocampus, striatum, midbrain, brainstem, pituitary, and hypothalamus.
CHX Neg (not) Positive_regulation (increased) of proENK in brainstem associated with medulla, midbrain and hippocampus
4) Confidence 0.04 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.18
CHX increased proENK and TH mRNA levels in the adrenal gland, but not in hippocampus, striatum, midbrain, brainstem, pituitary, and hypothalamus.
CHX Neg (not) Positive_regulation (increased) of proENK in striatum associated with medulla, midbrain and hippocampus
5) Confidence 0.04 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.18
CHX increased proENK and TH mRNA levels in the adrenal gland, but not in hippocampus, striatum, midbrain, brainstem, pituitary, and hypothalamus.
CHX Neg (not) Positive_regulation (increased) of proENK in pituitary associated with medulla, midbrain and hippocampus
6) Confidence 0.04 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.18
CHX increased proENK and TH mRNA levels in the adrenal gland, but not in hippocampus, striatum, midbrain, brainstem, pituitary, and hypothalamus.
CHX Neg (not) Positive_regulation (increased) of proENK in midbrain associated with medulla, midbrain and hippocampus
7) Confidence 0.04 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.18

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