INT88496

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.05
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
spinal cord 4
Hepa 1-6 4
DRG 4
myocytes 2
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 99.98 Very High Very High Very High
Hyperalgesia 10 99.90 Very High Very High Very High
Paracetamol 22 99.76 Very High Very High Very High
Spinal cord 4 98.28 Very High Very High Very High
Sciatic nerve 2 93.24 High High
agonist 10 84.60 Quite High
Inflammation 26 82.16 Quite High
Intracerebroventricular 4 75.00 Quite High
IPN 2 68.80 Quite High
Central nervous system 14 64.92 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 12 99.90 Very High Very High Very High
Pressure And Volume Under Development 8 99.50 Very High Very High Very High
Hepatocellular Cancer 2 82.52 Quite High
INFLAMMATION 28 82.16 Quite High
Toxicity 4 74.48 Quite High
Low Back Pain 1 72.60 Quite High
Rheumatoid Arthritis 5 71.08 Quite High
Hemophilus Infection 89 65.60 Quite High
Cancer 3 50.00 Quite Low
Necrosis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events.
Positive_regulation (sufficient) of Protein_catabolism (degradation) of IkappaBalpha in Hepa 1-6 associated with paracetamol
1) Confidence 0.53 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.16 Pain Relevance 0.90
Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events.
Positive_regulation (sufficient) of Protein_catabolism (degradation) of IkappaBalpha in Hepa 1-6 associated with paracetamol
2) Confidence 0.38 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.16 Pain Relevance 0.90
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Positive_regulation (activation) of Protein_catabolism (degradation) of I kappa B-alpha in spinal cord associated with pressure and volume under development and spinal cord
3) Confidence 0.36 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.52 Pain Relevance 0.55
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Positive_regulation (activation) of Protein_catabolism (degradation) of kappaB-alpha in spinal cord associated with pressure and volume under development and spinal cord
4) Confidence 0.36 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.53 Pain Relevance 0.55
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Positive_regulation (activation) of Protein_catabolism (degradation) of IkB-alpha in DRG associated with hyperalgesia
5) Confidence 0.33 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.68 Pain Relevance 0.90
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Positive_regulation (evaluated) of Protein_catabolism (degradation) of IkB-alpha in DRG associated with hyperalgesia
6) Confidence 0.33 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.68 Pain Relevance 0.91
Similarly, the study by Singer et al. showed that p38 MAPK and NF-kappa B may affect COX-2 expression in human airway myocytes via separate signaling pathways given the fact that SB203580 did not affect cytokine-stimulated IkappaBalpha degradation and NF-kappa B nuclear binding activity [23].
Positive_regulation (stimulated) of Protein_catabolism (degradation) of IkappaBalpha in myocytes associated with cytokine
7) Confidence 0.18 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.18 Pain Relevance 0.05
The NF-kappaB complex was composed of p50 and p65 subunits and its activation required inhibitor of NF-kappaBalpha degradation.
Positive_regulation (required) of Protein_catabolism (degradation) of NF-kappaBalpha
8) Confidence 0.01 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17896809 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox