INT88501

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.33
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 1
Tmie (Mus musculus)
Pain Link Frequency Relevance Heat
cva 8 96.82 Very High Very High Very High
tetrodotoxin 2 83.16 Quite High
headache 2 82.16 Quite High
agonist 21 80.12 Quite High
Kinase C 1 56.72 Quite High
Glutamate receptor 1 22.88 Low Low
imagery 7 7.72 Low Low
ischemia 6 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contracture 9 98.00 Very High Very High Very High
Thrombosis Related Under Development 2 96.82 Very High Very High Very High
Hypersensitivity 4 93.20 High High
Syndrome 10 91.84 High High
Osteoporotic Fractures 8 91.04 High High
Exanthema 4 90.48 High High
Eosinophilia 2 89.68 High High
Repression 67 89.20 High High
Diarrhoea 4 86.08 High High
Vomiting 4 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A slight increase in the annual incidence of venous thromboembolism (0.9% versus 0.6%) was observed at 3 years, but remained unchanged following the third year, without any underlying potential mechanism, as there is no known interaction between SR and parameters of hemostasis.
SR Neg (no) Binding (interaction) of associated with cva and thrombosis related under development
1) Confidence 0.31 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 1.37 Pain Relevance 0.13
In the intention-to-treat population, SR was associated with a 16% RR reduction of nonvertebral fractures over a three-year follow-up period (RR, 0.84; 95% CI: 0.70 to 0.99; P = 0.04).
SR Binding (associated) of
2) Confidence 0.23 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.25 Pain Relevance 0
Moreover, cartap inhibited the [(3)H]-ryanodine binding to the Ca(2+) release channel of SR in a dose-dependent manner.
SR Binding (binding) of
3) Confidence 0.14 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828278 Disease Relevance 0.62 Pain Relevance 0.08
However, mast cells lacking the major SOC channel Orai1 (22) show normal store content, suggesting a SOC channel–independent role of STIM1 in store refill, possibly through interaction with the IP3 receptors or SERCA pumps in the SR/ER.
SR Binding (interaction) of in mast cells
4) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0 Pain Relevance 0.07
The SR proteins generally enhance splicing via recognition of exonic splicing enhancers (ESEs), although they can act in other ways.
SR Binding (recognition) of
5) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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