INT88523

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Context Info
Confidence 0.01
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.76
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
plaques 2
epithelial cells 2
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 12 99.84 Very High Very High Very High
Inflammation 7 99.36 Very High Very High Very High
fibrosis 1 97.12 Very High Very High Very High
Angina 1 93.20 High High
Kinase C 4 90.64 High High
alcohol 1 86.84 High High
cytokine 2 82.04 Quite High
metalloproteinase 1 80.08 Quite High
abdominal pain 1 76.00 Quite High
ischemia 1 31.44 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 3 99.98 Very High Very High Very High
Pancreatitis 13 99.84 Very High Very High Very High
Reprotox - General 1 8 99.62 Very High Very High Very High
INFLAMMATION 7 99.36 Very High Very High Very High
Atherosclerosis 3 97.60 Very High Very High Very High
Metastasis 7 97.32 Very High Very High Very High
Fibrosis 1 97.12 Very High Very High Very High
Cv General 3 Under Development 1 93.20 High High
Cyst 2 92.60 High High
Alcohol Addiction 1 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Research during the last years, however, has elucidated that a number of growth factors and their receptors are overexpressed in CP, which is thought to contribute to the high degree of pancreatic fibrosis and to the proliferative potential of ductular cells in this disorder.
Positive_regulation (overexpressed) of Negative_regulation (number) of factors associated with fibrosis and chronic pancreatitis
1) Confidence 0.01 Published 2000 Journal Ann Ital Chir Section Abstract Doc Link 10829517 Disease Relevance 1.61 Pain Relevance 1.20
Prostate cancer (PCa) epithelial cells require a number of factors to facilitate their establishment and growth at a distant site of metastasis.
Positive_regulation (require) of Negative_regulation (number) of factors in epithelial cells associated with metastasis and reprotox - general 1
2) Confidence 0.01 Published 2007 Journal J. Cell. Biochem. Section Abstract Doc Link 17387734 Disease Relevance 0.83 Pain Relevance 0
Nonetheless, we directly tested and found that neither SMase C nor SMase D induced detectable decreases in cellular PC content (Table S3).
Neg (neither) Positive_regulation (induced) of Neg (neither) Negative_regulation (decreases) of PC
3) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.14 Pain Relevance 0.17
Local inflammation of the atherosclerotic plaques induces the expression of a number of growth factors and other potent molecules that contribute to vascular remodeling.
Positive_regulation (induces) of Negative_regulation (number) of factors in plaques associated with atherosclerotic plaque and inflammation
4) Confidence 0.00 Published 2001 Journal Herz Section Abstract Doc Link 11349622 Disease Relevance 1.18 Pain Relevance 0.38

General Comments

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