INT88544

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 102
Total Number 112
Disease Relevance 68.80
Pain Relevance 14.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
ECM 14
chondrocyte 4
fibroblasts 4
cartilage 4
macrophages 2
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 717 100.00 Very High Very High Very High
rheumatoid arthritis 498 100.00 Very High Very High Very High
chemokine 290 100.00 Very High Very High Very High
metalloproteinase 265 100.00 Very High Very High Very High
Inflammatory mediators 42 100.00 Very High Very High Very High
Endocannabinoid 24 99.64 Very High Very High Very High
Central nervous system 111 99.52 Very High Very High Very High
Osteoarthritis 387 98.76 Very High Very High Very High
Inflammation 955 98.58 Very High Very High Very High
Chronic pancreatitis 329 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Uterine Fibroids 1920 100.00 Very High Very High Very High
INFLAMMATION 1106 100.00 Very High Very High Very High
Rheumatoid Arthritis 883 100.00 Very High Very High Very High
Adhesions 691 100.00 Very High Very High Very High
Glaucoma 182 100.00 Very High Very High Very High
Shock 37 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 751 99.98 Very High Very High Very High
Fibrosis 475 99.84 Very High Very High Very High
Meningoencephalitis 165 99.84 Very High Very High Very High
Hyperplasia 29 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunocytochemistry, flow cytometry, and ELISA assays we showed that different cell adhesion molecules (CAMs) and extracellular matrix ECM proteins were expressed and released by AM cells during culture.
Gene_expression (expressed) of ECM in extracellular matrix associated with adhesions
1) Confidence 0.75 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10833307 Disease Relevance 0.48 Pain Relevance 0.57
The primary role of these cytokines is to modulate the expression of matrix metalloproteinases and cartilage ECM proteins.
Gene_expression (expression) of ECM in ECM associated with metalloproteinase and cytokine
2) Confidence 0.58 Published 2004 Journal BioDrugs Section Abstract Doc Link 14733605 Disease Relevance 1.14 Pain Relevance 0.76
Platelet-derived growth factor (PDGF) is a potent stimulator of PSC proliferation, and transforming growth factor-beta, PDGF, and basic fibroblast growth factor stimulate ECM synthesis by PSC.
Gene_expression (synthesis) of ECM in fibroblast associated with primary sclerosing cholangitis
3) Confidence 0.58 Published 2008 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 18336654 Disease Relevance 1.78 Pain Relevance 0.34
Tissue engineering approaches include the use of cells in specific cell carrier constructs or scaffolds which can provide specific cellular microenvironments directing desired cellular activities, including ECM production, cell proliferation and activation of cell signaling pathways [10,11]. or allow delivery of bioactive molecules, proteins or drugs [12,13].
Gene_expression (production) of ECM
4) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0.04
Several of the biologic considerations involved in creating a tissue engineered meniscus have also been described by Arnoczky [7], who has summarized several of the important cell carrier (or scaffold) features, including support of cell proliferation and ECM production, diffusion of nutrients, possible use as a carrier for cytokines, and biomechanical considerations.
Gene_expression (production) of ECM associated with cytokine
5) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.42 Pain Relevance 0.21
ECM produced by cells filled cavities within the 3D sponge matrix and was present between and around cells (Figure 3B).
Gene_expression (produced) of ECM in cavities
6) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0
Arnoczky has summarized major issues related to meniscal repair using scaffolds and cells [6], noting that although some preliminary data had been done using meniscal fibrochondrocytes, fibroblasts, or synovial cells to produce a fibrocartilaginous tissue, additional studies were needed to characterize the cellular features and ECM produced.
Gene_expression (produced) of ECM in synovial cells
7) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.55 Pain Relevance 0.22
ECM produced by cells filled cavities within the 3D sponge matrix and was present between and around cells (Figure 3B).
Gene_expression (present) of ECM in cavities
8) Confidence 0.35 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0
3D: three-dimensional; ECM: extracellular matrix; TGF-?
Gene_expression (extracellular matrix) of ECM in extracellular matrix
9) Confidence 0.35 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0
The collagen sponge, in contrast, is easily manipulated, does not require use of specialized chondrogenic media to allow ECM production, provides ample room for meniscal cell expansion and ECM production, and is easily embedded for morphologic studies.


Gene_expression (production) of ECM
10) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.29 Pain Relevance 0.07
Knowledge of how culture microenvironments influence meniscal cell ECM production is important; the collagen sponge culture methodology provides a useful in vitro tool for study of meniscal cell biology.



Gene_expression (production) of ECM
11) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Abstract Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0
The collagen sponge, in contrast, is easily manipulated, does not require use of specialized chondrogenic media to allow ECM production, provides ample room for meniscal cell expansion and ECM production, and is easily embedded for morphologic studies.


Gene_expression (production) of ECM
12) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.27 Pain Relevance 0.07
The aim of this study was to test a three-dimensional (3D) collagen sponge microenvironment (without added growth factors) for its ability to provide a microenvironment supportive for meniscal cell extracellular matrix (ECM) production, and to test the responsiveness of cells cultured in this manner to transforming growth factor-?
Gene_expression (production) of ECM in ECM
13) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Abstract Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0
Although micromass culture did show ECM production, this technique is extremely tedious and limited in analytical studies.
Gene_expression (production) of ECM
14) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.11 Pain Relevance 0.03
The present findings on ECM production under control conditions by human meniscal cells provides an important advance over routine monolayer cell culture.
Gene_expression (production) of ECM
15) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0
In contrast, Linear pattern may relate to the worst prognosis because cancer cells may have already deeply penetrated the ECM in spite of the density of the surrounding type IV collagen, and such cancer may have already become a potentially systemic disease even it is diagnosed as early stage by conventional pathology.
Gene_expression (penetrated) of ECM associated with cancer and disease
16) Confidence 0.29 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.13 Pain Relevance 0
Furthermore, it has been shown that LPS-activated macrophages stimulate the synthesis of ECM proteins by PSC [21].
Gene_expression (synthesis) of ECM in macrophages associated with primary sclerosing cholangitis
17) Confidence 0.26 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.75 Pain Relevance 0.38
TGFbeta was subsequently confirmed as a key regulator of ECM production and PSC proliferation due to its inhibition of MMPs in an autocrine fashion which enhanced fibrogenesis by reducing collagen degradation [23].
Gene_expression (production) of ECM associated with fibrosis and primary sclerosing cholangitis
18) Confidence 0.23 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.59 Pain Relevance 0.24
However, our findings may also be due to several other factors: first, we used PBMC, which have only been in direct contact with the inflamed pancreas to a very minor extent; second, upregulation of PSC-produced ECM proteins seems to be a function of PBMC in general, not particularly of PBMC which are derived from CP patients; and third, our study addresses interactions of PBMC and PSC in an artificial set-up which may reflect the experimental processing of both PSC and PBMC.
Gene_expression (produced) of ECM in pancreas associated with primary sclerosing cholangitis and chronic pancreatitis
19) Confidence 0.23 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.15 Pain Relevance 0.23
In vitro increase of ECM production is induced by PBMC
Gene_expression (production) of ECM
20) Confidence 0.23 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.77 Pain Relevance 0.09

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