INT88545

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 16.67
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
extracellular matrix 2
stroma 1
macrophages 1
stellate cells 1
fibroblasts 1
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 165 99.90 Very High Very High Very High
Cannabinoid 52 99.22 Very High Very High Very High
Inflammation 177 99.20 Very High Very High Very High
metalloproteinase 68 99.04 Very High Very High Very High
Kinase C 3 97.70 Very High Very High Very High
fibrosis 69 97.34 Very High Very High Very High
Central nervous system 18 97.00 Very High Very High Very High
Osteoarthritis 66 96.40 Very High Very High Very High
rheumatoid arthritis 58 93.04 High High
Chronic pancreatitis 194 89.72 High High
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 396 100.00 Very High Very High Very High
Viral Meningitis 42 100.00 Very High Very High Very High
Cancer 467 99.92 Very High Very High Very High
Apoptosis 131 99.90 Very High Very High Very High
Metastasis 105 99.36 Very High Very High Very High
Injury 63 99.32 Very High Very High Very High
INFLAMMATION 194 99.20 Very High Very High Very High
Hypoxia 60 99.16 Very High Very High Very High
Adhesions 302 99.14 Very High Very High Very High
Chondrosarcoma 24 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunocytochemistry, flow cytometry, and ELISA assays we showed that different cell adhesion molecules (CAMs) and extracellular matrix ECM proteins were expressed and released by AM cells during culture.
Localization (released) of ECM in extracellular matrix associated with adhesions
1) Confidence 0.78 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10833307 Disease Relevance 0.48 Pain Relevance 0.57
The cancer cell and stroma both modulate the process of invasion by remodeling the ECM with tumor-associated proteases such as matrix metalloproteinase (MMPs), which subsequently breakdown proteins of the ECM such as collagens and release the cryptic information [8,9].
Localization (release) of ECM in stroma associated with cancer and metalloproteinase
2) Confidence 0.31 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.98 Pain Relevance 0.10
This assumption is underlined by increased ECM protein secretion in TNFalpha- and LPS-treated PSC and a concomitant increase in collagen1 and fibronectin as well as in pro-inflammatory cytokines IL-6 and MCP-1 following coculture of PSC with PBMC.
Localization (secretion) of ECM protein associated with inflammation, primary sclerosing cholangitis and cytokine
3) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.15 Pain Relevance 0.51
To evaluate whether mononuclear cells alter ECM secretion of cultured primary human PSC in vitro, a co-culture system with PBMC in the upper chamber and PSC in the lower chamber was used.
Localization (secretion) of ECM in upper associated with primary sclerosing cholangitis
4) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.78 Pain Relevance 0.10
Increased ECM protein secretion is not accompanied by increased transcription
Localization (secretion) of ECM protein
5) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.02 Pain Relevance 0.48
We have previously shown that periostin, which sustains stellate cell activity, is mostly secreted by PSC around degenerating acini/tubular complexes [28], possibly marking the invasive front of the activated stroma where newly deposited ECM gradually replaces the functional parenchyma.
Localization (secreted) of ECM in parenchyma associated with primary sclerosing cholangitis
6) Confidence 0.21 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.68 Pain Relevance 0.03
These differential patterns of expression aid the tumor in ECM transmigration and ultimately metastasis.
Localization (transmigration) of ECM associated with cancer and metastasis
7) Confidence 0.13 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.08 Pain Relevance 0
These cells resist apoptosis and secrete ECM molecules to renovate basement membrane.
Localization (secrete) of ECM in basement membrane associated with apoptosis
8) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.57 Pain Relevance 0.10
It is also proposed that fibroblasts from the chronic wounds migrate into the fibrin deposit; secrete ECM proteins causing wound contraction and scar formation [11].
Localization (secrete) of ECM in fibroblasts associated with cicatrix and injury
9) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.29 Pain Relevance 0.16
ATRA is known to act through different pathways including MAP kinase pathway39,41,42 and protein kinase C pathway.39,43 In this study, we demonstrated an antifibrotic potential of ATRA on overall production of collagens secreted into the ECM as well as the mRNA of collagen types 1, 3 and 4, fibronectin and versican in leiomyoma cells.
Localization (secreted) of ECM associated with kinase c and uterine fibroids
10) Confidence 0.13 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.60 Pain Relevance 0.16
To exclude that potential anti-proliferative effects of cannabinoids influenced evaluation of cytokine and ECM protein secretion, treatment was begun when the cells reached 100% confluency.


Localization (secretion) of ECM associated with cannabinoid and cytokine
11) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.22 Pain Relevance 0.17
In the past years, pancreatic stellate cells (activated myofibroblasts; PSC) have been identified as major determinants of pancreatic fibrosis: they have been shown to be the major source of extracellular matrix production[10], [11] and to stringently control the balance of ECM secretion and digestion by producing matrix metalloproteinases and their corresponding inhibitors[12].
Localization (secretion) of ECM in stellate cells associated with fibrosis, primary sclerosing cholangitis and metalloproteinase
12) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 1.06 Pain Relevance 0.54
shRNA 3B is effective in reducing intracellular retention of MT-COMP and other ECM proteins
Localization (retention) of ECM
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.18 Pain Relevance 0
The goal of these studies was to determine if reduction in MT-COMP synthesis by the most effective shRNA (3B) can prevent and/or eliminate intracellular retention of COMP and other ECM proteins.
Localization (retention) of ECM
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.26 Pain Relevance 0
Articular cartilage explants subjected to pro-inflammatory cytokines provide a biologically relevant model to study the time-dependent release of ECM degradation-fragments [10-12].
Localization (release) of ECM in Articular cartilage associated with inflammation and cytokine
15) Confidence 0.07 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2426686 Disease Relevance 0.24 Pain Relevance 0.27
In summary, these data show that both serine and metalloproteases secreted by AGE isolate (T1 genotype), exhibit properties to degrade ECM, which may facilitate amoebic invasion of the deeper lying tissues of the CNS.
Localization (secreted) of ECM associated with central nervous system and viral meningitis
16) Confidence 0.06 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.85 Pain Relevance 0.05
Secretion of ECM Proteinases
Localization (Secretion) of ECM
17) Confidence 0.05 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.13 Pain Relevance 0.29
While most studies have focused on the effects of PHT on the fibroblast in the pathophysiology underlying GO, few studies have investigated the potential regulatory role of macrophages in extracellular matrix (ECM) turnover and secretion of proinflammatory mediators.
Localization (secretion) of ECM in macrophages
18) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0.04
preparation Matrigel, which is a secreted ECM rich in laminin [159], also
Localization (secreted) of ECM
19) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.30 Pain Relevance 0
, have direct and indirect pro-inflammatory effects to regulate the degradation of ECM components by stimulating secretion of proteolytic enzymes and other mediators, such as MMPs, aggrecanases and other members of the 'a disintegrin and metallo-proteinase with thrombospondin motifs' (ADAMTS) gene family, NO, and prostaglandin E2 [149,177,178].
Localization (secretion) of ECM associated with inflammation
20) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.96 Pain Relevance 0.33

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