INT88550

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 6.61
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SW480 1
colon 1
platelets 1
mast cell 1
PAR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 98.44 Very High Very High Very High
Inflammation 62 97.80 Very High Very High Very High
Pain 6 94.24 High High
Angina 3 89.24 High High
Hyperalgesia 4 83.76 Quite High
allodynia 1 82.40 Quite High
Bile 7 73.72 Quite High
Analgesic 2 61.84 Quite High
aspirin 6 58.08 Quite High
cytokine 20 50.20 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 99.48 Very High Very High Very High
Cancer 255 98.76 Very High Very High Very High
Death 66 98.60 Very High Very High Very High
INFLAMMATION 66 97.80 Very High Very High Very High
Coagulation Disorder 1 97.08 Very High Very High Very High
Colon Cancer 475 96.80 Very High Very High Very High
Pressure And Volume Under Development 2 95.16 Very High Very High Very High
Apoptosis 661 94.76 High High
Pain 6 94.24 High High
Liver Cancer 11 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While in some cells the increase in Par-4 alone is sufficient to cause cell death [19,24,25], the ectopic introduction of Par-4 into HT29 colon cancer cells did not induce apoptosis but rather heightened cell sensitivity to the apoptotic stimulus of 5-FU.
Positive_regulation (increase) of Par-4 in colon associated with colon cancer, apoptosis and death
1) Confidence 0.68 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.97 Pain Relevance 0
Par-4 levels were increased in cells treated with COX inhibitors such as NS-398, nimesulide, SC-58125, and sulindac sulfide.
Positive_regulation (increased) of Par-4
2) Confidence 0.56 Published 2000 Journal Gastroenterology Section Body Doc Link 10833474 Disease Relevance 0 Pain Relevance 0
To determine the consequence of increased Par-4 binding to NF?
Positive_regulation (increased) of Par-4
3) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.07 Pain Relevance 0
Figure 5A depicts the immunofluorescent signal for Par-4 (red) which was distributed in both the cytoplasm and nuclei, while the signal for NF?
Positive_regulation (distributed) of Par-4
4) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.06 Pain Relevance 0
The clinical relevance of the Par-4-modulated genes with NF?
Positive_regulation (relevance) of Par-4-modulated
5) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.57 Pain Relevance 0
In contrast, the inhibitor treatment resulted in increased Par-4 binding to NF?
Positive_regulation (increased) of Par-4
6) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.13 Pain Relevance 0
In contrast, the inhibitor treatment resulted in increased Par-4 binding to NF?
Positive_regulation (resulted) of Par-4
7) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.13 Pain Relevance 0
Next, we performed ChIP-qPCR assays in Par-4- versus empty vector-transfected HT29 cells to validate the occupancies of both p65 and p50 NF?
Positive_regulation (assays) of Par-4
8) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.80 Pain Relevance 0
Similar restricted cytoplasmic colocalization was seen for Par-4 and I?
Positive_regulation (seen) of Par-4
9) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0 Pain Relevance 0
Following AKT1 knockdown, the cytoplasmic Par-4/p65 colocalized signal was significantly enhanced (Figure 6; Par4/p65 colocalize panel for pshAkt1).
Positive_regulation (enhanced) of Par-4
10) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0 Pain Relevance 0
B transcriptional activity via direct Par-4/NF?
Positive_regulation (direct) of Par-4
11) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.45 Pain Relevance 0
In HT29 and SW480 cells, pharmacologic (ISC-4) or genetic (pshAkt1) suppression of AKT1 activity resulted in increased Par-4/NF?
Positive_regulation (increased) of Par-4 in SW480
12) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.82 Pain Relevance 0
Treatment of platelets with thrombin (activates PAR1 and PAR4 thrombin receptors), SFLLRN (PAR1), AYPGKF (PAR4), collagen (alpha2beta1 and GPVI/FCgammaIIR receptors) and U46619 (TXA(2)) resulted in strong activation of p38 MAPK.
Positive_regulation (activates) of PAR4 in platelets
13) Confidence 0.15 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 15583748 Disease Relevance 0.50 Pain Relevance 0.19
Of the four family members, PAR1, PAR3, and PAR4 are primarily activated by thrombin while PAR2 is activated by trypsin, mast cell tryptase, and clotting factors VIIa and Xa.
Positive_regulation (activated) of PAR4 in mast cell associated with coagulation disorder
14) Confidence 0.12 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.80 Pain Relevance 0.11
Protease-activated receptor-1 (PAR1), PAR2 and PAR4 activation can alter the gastrointestinal motility.
Positive_regulation (activation) of PAR4
15) Confidence 0.11 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335921 Disease Relevance 0 Pain Relevance 0.04
Activation of PAR1, PAR2 and PAR4 either by proteinases or by selective agonists causes inflammation inducing most of the cardinal signs of inflammation: swelling, redness, and pain.
Positive_regulation (Activation) of PAR4 associated with pain, pressure and volume under development, inflammation and agonist
16) Confidence 0.05 Published 2005 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 15962118 Disease Relevance 1.31 Pain Relevance 0.91

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