INT88559

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Context Info
Confidence 0.56
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 25
Total Number 29
Disease Relevance 21.81
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink1)
Anatomy Link Frequency
liver 4
Spink1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 132 99.80 Very High Very High Very High
fibrosis 28 98.70 Very High Very High Very High
alcohol 10 95.68 Very High Very High Very High
Inflammation 25 86.96 High High
Inflammatory response 3 82.16 Quite High
cytokine 2 79.64 Quite High
palliative 4 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 243 99.96 Very High Very High Very High
Cancer 122 99.80 Very High Very High Very High
Calcification 12 99.44 Very High Very High Very High
Cystic Fibrosis 14 98.72 Very High Very High Very High
Metastasis 36 96.48 Very High Very High Very High
Disease 116 96.12 Very High Very High Very High
Colon Cancer 136 94.88 High High
Genetic Predisposition To Disease 3 94.84 High High
Cirrhosis 5 93.88 High High
Diabetes Mellitus 40 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that the (cationic) pancreatic secretory trypsin inhibitor (PSTI) is down-regulated after a protein-deficient diet.
Negative_regulation (regulated) of PSTI
1) Confidence 0.56 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.25 Pain Relevance 0.13
Using a newly developed PSTI-I ELISA, we can show that the PSTI-I/trypsinogen ratio is not decreased but rather increased in WBN/Kob rats compared to healthy Wistar rats.
Neg (not) Negative_regulation (decreased) of PSTI-I
2) Confidence 0.55 Published 2002 Journal Pancreatology Section Body Doc Link 12123090 Disease Relevance 0.09 Pain Relevance 0
Recently an association was identified between idiopathic pancreatitis in the USA and Europe and mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene (previously termed pancreatic secretory trypsin inhibitor, PSTI).
Negative_regulation (inhibitor) of SPINK1 associated with pancreatitis
3) Confidence 0.51 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120202 Disease Relevance 0.88 Pain Relevance 0.09
We hypothesize that the (cationic) pancreatic secretory trypsin inhibitor (PSTI) is down-regulated after a protein-deficient diet.
Negative_regulation (regulated) of pancreatic secretory trypsin inhibitor
4) Confidence 0.49 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.26 Pain Relevance 0.13
Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene.
Negative_regulation (inhibitor) of PSTI associated with fibrosis, cystic fibrosis and chronic pancreatitis
5) Confidence 0.47 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.64 Pain Relevance 0.30
It arose from recent pancreatitis research that some cases of chronic pancreatitis are associated with mutations of the serine protease inhibitor, Kazal type-1 (SPINK1).
Negative_regulation (inhibitor) of SPINK1 associated with pancreatitis and chronic pancreatitis
6) Confidence 0.41 Published 2004 Journal Dig Dis Section Abstract Doc Link 15753612 Disease Relevance 0.55 Pain Relevance 0.10
SPINK1 Serine protease inhibitor, Kazal type I
Negative_regulation (inhibitor) of SPINK1
7) Confidence 0.41 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.52 Pain Relevance 0.33
To explore the possibility that PSTI may be secreted at lower levels or contain a mutation in the WBN/Kob rat, we investigated the masses of PSTI-I and -II and asked whether the ratio of PSTI/trypsinogen is decreased in animals with CP.
Spec (whether) Negative_regulation (decreased) of PSTI associated with chronic pancreatitis
8) Confidence 0.40 Published 2002 Journal Pancreatology Section Abstract Doc Link 12123090 Disease Relevance 0.44 Pain Relevance 0.44
Serine protease inhibitor, Kazal type 1 (SPINK1) is a potent protease inhibitor which prevents premature intrapancreatic activation of trypsin and pancreatic autodigestion.
Negative_regulation (inhibitor) of SPINK1
9) Confidence 0.36 Published 2007 Journal Korean J Gastroenterol Section Abstract Doc Link 17641557 Disease Relevance 0.57 Pain Relevance 0.31
Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene.
Negative_regulation (inhibitor) of SPINK1 associated with fibrosis, cystic fibrosis and chronic pancreatitis
10) Confidence 0.35 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.65 Pain Relevance 0.30
SETTING: Cationic trypsinogen (PRSS1) and the serine protease inhibitor, Kazal type 1 (SPINK1), were analyzed in patients with pancreatitis of unclear origin.
Negative_regulation (inhibitor) of SPINK1
11) Confidence 0.34 Published 2003 Journal JOP Section Body Doc Link 12853682 Disease Relevance 0 Pain Relevance 0
We proposed the hypothesis that, if the function of the PSTI is impaired by its genetic mutation, trypsin may easily promote autodigestion causing pancreatitis and we performed a mutational analysis of the PSTI gene in patients with pancreatitis.
Negative_regulation (impaired) of PSTI associated with pancreatitis
12) Confidence 0.30 Published 2003 Journal JOP Section Abstract Doc Link 12629264 Disease Relevance 0.34 Pain Relevance 0.07
Here we analysed 96 unrelated children and adolescents with CP for mutations in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), a pancreatic trypsin inhibitor.
Negative_regulation (inhibitor) of SPINK1 associated with chronic pancreatitis
13) Confidence 0.20 Published 2000 Journal Nat. Genet. Section Abstract Doc Link 10835640 Disease Relevance 0.78 Pain Relevance 0.64
In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP.
Negative_regulation (inhibitor) of SPINK1 associated with pancreatitis
14) Confidence 0.20 Published 2002 Journal Gastroenterology Section Abstract Doc Link 12360463 Disease Relevance 0.96 Pain Relevance 0.09
Intronic mutations, rather than N34S itself (IVS1-37T>C + N34S + IVS3-69insTTTT complex), may be associated with the decreased function of the PSTI.
Negative_regulation (decreased) of PSTI
15) Confidence 0.19 Published 2003 Journal JOP Section Abstract Doc Link 12629264 Disease Relevance 0.40 Pain Relevance 0.07
Pancreatic secretory trypsin inhibitor (PSTI) is a potent natural inhibitor of trypsin.
Negative_regulation (inhibitor) of PSTI
16) Confidence 0.19 Published 2003 Journal JOP Section Abstract Doc Link 12629264 Disease Relevance 0.31 Pain Relevance 0.07
Here we analysed 96 unrelated children and adolescents with CP for mutations in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), a pancreatic trypsin inhibitor.
Negative_regulation (inhibitor) of SPINK1 associated with chronic pancreatitis
17) Confidence 0.15 Published 2000 Journal Nat. Genet. Section Abstract Doc Link 10835640 Disease Relevance 0.77 Pain Relevance 0.64
Recently, a point mutation (N34S) in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), was found in approximately 20% of patients with CP.
Negative_regulation (inhibitor) of SPINK1 associated with chronic pancreatitis
18) Confidence 0.13 Published 2002 Journal Am. J. Gastroenterol. Section Abstract Doc Link 12014716 Disease Relevance 0.63 Pain Relevance 0.66
Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the serine protease inhibitor, Kazal type 1 (SPINK1) gene in patients with alcoholic chronic pancreatitis.
Negative_regulation (inhibitor) of SPINK1 associated with fibrosis, cystic fibrosis and chronic pancreatitis
19) Confidence 0.13 Published 2003 Journal Eur. J. Hum. Genet. Section Title Doc Link 12939655 Disease Relevance 1.54 Pain Relevance 1.03
Serum PSTI concentration was decreased in patients with the IVS3 + 2T > C mutation.
Negative_regulation (decreased) of PSTI
20) Confidence 0.12 Published 2008 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 18336671 Disease Relevance 0.96 Pain Relevance 0.99

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