INT8856

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Context Info
Confidence 0.49
First Reported 1981
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.06
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peripheral nervous system 1
Th2 cell 1
T cell 1
Schwann cells 1
Pmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 8 100.00 Very High Very High Very High
Neuritis 27 99.70 Very High Very High Very High
Inflammation 3 93.32 High High
tolerance 3 70.16 Quite High
Freund adjuvant 1 35.20 Quite Low
Demyelination 1 31.12 Quite Low
Sciatic nerve 1 25.04 Quite Low
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 4 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 25 99.96 Very High Very High Very High
Neuritis 2 99.70 Very High Very High Very High
Syndrome 4 99.58 Very High Very High Very High
Hypersensitivity 2 99.52 Very High Very High Very High
Demyelinating Disease 2 94.20 High High
INFLAMMATION 3 93.32 High High
Immunization 2 84.48 Quite High
Recurrence 1 72.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Allergic neuritis: phospholipid requirement for the disease-inducing conformation of the P2 protein.
Positive_regulation (requirement) of P2 protein associated with hypersensitivity, disease and neuritis
1) Confidence 0.49 Published 1981 Journal Biochim. Biophys. Acta Section Title Doc Link 6170341 Disease Relevance 0.49 Pain Relevance 0.20
Peptide 57-81 could also be used to stimulate a P2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats.
Positive_regulation (stimulate) of P2 protein in T cell associated with neuritis
2) Confidence 0.40 Published 1988 Journal J. Neuroimmunol. Section Abstract Doc Link 2456303 Disease Relevance 0.54 Pain Relevance 0.45
The P2 protein of the peripheral nervous system myelin is a neuritogenic protein capable of inducing experimental allergic neuritis (EAN) in the Lewis rat.
Positive_regulation (inducing) of P2 protein in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis and neuritis
3) Confidence 0.18 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 11104509 Disease Relevance 0.55 Pain Relevance 0.54
Both EAN and GBS are associated with upregulated T and B cells responses to PNS myelin proteins including P2 protein, and by changes of the Th1/Th2 cell balance in favor of Th1.
Positive_regulation (upregulated) of P2 protein in Th2 cell associated with peripheral nervous system, syndrome and neuritis
4) Confidence 0.14 Published 1998 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 9600221 Disease Relevance 1.23 Pain Relevance 0.93
Cytoplasmic P2 was detected in Schwann cells by immunofluorescent labelling and the results of proliferation assays in this study suggest that endogenous P2 protein was processed by the Schwann cells and presented to T-cell lines in association with MHC class II molecules.
Positive_regulation (processed) of P2 protein in Schwann cells
5) Confidence 0.10 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1381378 Disease Relevance 0.25 Pain Relevance 0.32

General Comments

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