INT88568

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RRM1) nucleoplasm (RRM1) small molecule metabolic process (RRM1)
oxidoreductase activity (RRM1) cytoplasm (RRM1)
RRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
Clonidine 4 97.68 Very High Very High Very High
Paracetamol 6 97.60 Very High Very High Very High
imagery 30 88.16 High High
agonist 4 87.40 High High
depression 1 71.80 Quite High
positron emission tomography 12 67.12 Quite High
medulla 1 57.60 Quite High
cytokine 42 5.00 Very Low Very Low Very Low
Central nervous system 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 100.00 Very High Very High Very High
Cancer 206 99.20 Very High Very High Very High
Breast Cancer 7 98.12 Very High Very High Very High
Toxicity 16 88.44 High High
Cold Sores 367 86.08 High High
Viral Infection 8 84.20 Quite High
Depression 1 71.80 Quite High
Death 7 67.36 Quite High
Suicidal Behaviour 3 64.40 Quite High
Metastasis 10 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since clonidine differentially modulated blink reflex responses, it is likely to assume that such a disfacilitation concerns mostly pontine units mediating the R1.
Positive_regulation (mediating) of R1 associated with clonidine
1) Confidence 0.41 Published 2000 Journal Brain Res. Section Abstract Doc Link 10837815 Disease Relevance 0.07 Pain Relevance 0.49
Tumor-sensitivity towards gemcitabine can be increased with COX inhibitory anti-inflammatory agents and ribonucleotide reductase (RR) inhibitor flavopiridol.
Positive_regulation (increased) of ribonucleotide reductase associated with inflammation and cancer
2) Confidence 0.18 Published 2004 Journal Neoplasma Section Abstract Doc Link 15640956 Disease Relevance 0.98 Pain Relevance 0.41
These vectors retained an intact viral tk gene and contained a lac Z insertional mutation within the gene encoding RR, while MGH-1 bore additional mutation at both ?
Positive_regulation (encoding) of RR
3) Confidence 0.04 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.76 Pain Relevance 0.24
Our results show that the distribution of OG488-prothrombin in the presence of PPACK overlapped with the binding distribution of AF647-annexin A5 (Fig. 3A), resulting in an increase in the overlap coefficient Rr of prothrombin and annexin A5 labeling (Fig. 3C).
Positive_regulation (increase) of Rr
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0 Pain Relevance 0

General Comments

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