INT88571

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.08
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
hip 1
femur 1
Tcas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 211 100.00 Very High Very High Very High
tricyclic antidepressant 29 100.00 Very High Very High Very High
fluoxetine 26 99.52 Very High Very High Very High
tramadol 9 99.44 Very High Very High Very High
local anesthetic 5 99.24 Very High Very High Very High
Serotonin 31 98.08 Very High Very High Very High
Sciatic nerve 5 80.40 Quite High
opiate 8 79.20 Quite High
noradrenaline 2 76.96 Quite High
opioid receptor 1 74.28 Quite High
Disease Link Frequency Relevance Heat
Convulsion 7 99.90 Very High Very High Very High
Renal Insufficiency 2 91.04 High High
Serotonin Syndrome 1 88.72 High High
Cancer 8 86.92 High High
Malignant Neoplastic Disease 9 86.56 High High
Cerebrovascular Disease 10 86.04 High High
Disease 23 80.48 Quite High
Frailty 16 78.88 Quite High
Psychosis 8 77.36 Quite High
Sleep Disorders 8 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: During the study period 9.8% of patients received a prescription for an antidepressant, there was a 40% increase in the prescribing rate of TCAs and a 460% increase in SSRI prescribing.
Positive_regulation (increase) of TCAs
1) Confidence 0.34 Published 2000 Journal J Affect Disord Section Body Doc Link 10837883 Disease Relevance 0 Pain Relevance 0
TCAs with a tertiary amine appear more effective in penetrating these membrane barriers than TCAs with a secondary amine.
Spec (appear) Positive_regulation (effective) of TCAs associated with tricyclic antidepressant
2) Confidence 0.19 Published 2003 Journal Pain Section Abstract Doc Link 12749958 Disease Relevance 0 Pain Relevance 1.04
We observed a similar increase in fracture risk for users of SSRIs and TCAs.
Positive_regulation (increase) of TCAs associated with ssri
3) Confidence 0.06 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744781 Disease Relevance 0 Pain Relevance 0.39
Compared with individuals who had never used the anti-depressant in question, the risk of hip/femur fracture increased with current use of SSRIs (crude OR 2.88 [95% CI 2.40–3.46]) and TCAs (crude OR 2.22 [95% CI 1.84–2.68]).
Positive_regulation (increased) of TCAs in femur associated with ssri
4) Confidence 0.04 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744781 Disease Relevance 0.56 Pain Relevance 0.43
Vestergaard et al. reported a dose-dependent increase in fracture risk for sedating TCAs and most SSRIs.
Positive_regulation (increase) of TCAs associated with ssri
5) Confidence 0.04 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744781 Disease Relevance 0 Pain Relevance 0.42
So, fluvoxamine (CYP1A2 inhibitor) can cause an increase of blood levels of theophyllin or caffeine, while paroxetine and fluoxetine (CYP2D6 inhibitors) an increase of concentration of TCAs or atypical antipsychotics.
Positive_regulation (increase) of TCAs in blood associated with fluoxetine
6) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515899 Disease Relevance 0.35 Pain Relevance 0.49
Compared with individuals who had never used the anti-depressant in question, the risk of hip/femur fracture increased with current use of SSRIs (crude OR 2.88 [95% CI 2.40–3.46]) and TCAs (crude OR 2.22 [95% CI 1.84–2.68]).
Positive_regulation (increased) of TCAs in hip associated with ssri
7) Confidence 0.01 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744781 Disease Relevance 0.56 Pain Relevance 0.43
Tramadol can induce convulsions and increase the potential for SSRIs, TCAs, anti-psychotics and other seizure threshold-lowering medicinal products to cause convulsions.
Positive_regulation (increase) of TCAs associated with tramadol, convulsion, tricyclic antidepressant and ssri
8) Confidence 0.01 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544357 Disease Relevance 0.60 Pain Relevance 1.22

General Comments

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