INT88586

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga7) cytoplasm (Itga7)
Anatomy Link Frequency
dopaminergic neurons 1
Itga7 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 9 99.16 Very High Very High Very High
Pain 5 96.44 Very High Very High Very High
Morphine 4 96.44 Very High Very High Very High
Nicotine 8 96.26 Very High Very High Very High
antinociception 3 95.96 Very High Very High Very High
IPN 4 95.60 Very High Very High Very High
aspirin 3 84.92 Quite High
Analgesic 5 84.64 Quite High
tetrodotoxin 3 84.12 Quite High
narcan 2 78.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 96.94 Very High Very High Very High
Pain 2 96.44 Very High Very High Very High
Inflammatory Pain 4 95.60 Very High Very High Very High
Nociception 2 76.64 Quite High
Aging 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that activation of alpha7 nicotinic receptors by choline elicits antinociceptive effects both in an acute thermal pain model and in an inflammatory pain model.
Positive_regulation (activation) of alpha7 associated with pain, ipn and antinociceptive
1) Confidence 0.67 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780465 Disease Relevance 0.34 Pain Relevance 1.27
Since the first targeted disruption in 1995 of the gene encoding the beta2-subunit of the nicotinic acetylcholine receptor (nAChR), all but a few of the mammalian nAChR subunits have been disrupted (i.e. alpha7, alpha4, alpha3, alpha9, beta4 and beta3).
Positive_regulation (disrupted) of alpha7 associated with targeted disruption
2) Confidence 0.49 Published 2000 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 10838608 Disease Relevance 0.25 Pain Relevance 0.12
These results demonstrate that in nigral dopaminergic neurons, nicotine can elicit Ca2+ mobilization via activation of two distinct nAChR subtypes: that of beta2-subunit-containing nAChR followed by activation of Na+ channel and T-type Ca2+ channels, and/or activation of alpha7-subunit-containing nAChR.
Positive_regulation (activation) of alpha7 in dopaminergic neurons associated with nicotine
3) Confidence 0.45 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10947823 Disease Relevance 0 Pain Relevance 0.61
Furthermore, the antinociceptive effect of epibatidine was related to the activation of alpha7 and/or alpha9 nAChRs since methyllycaconitine (MLA) and mecamylamine but not dihydro-beta-erythroidine (DHbetaE) reverted this effect.
Positive_regulation (activation) of alpha7 associated with antinociceptive
4) Confidence 0.24 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.30 Pain Relevance 0.37

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