INT886

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2010
Negated 22
Speculated 24
Reported most in Abstract
Documents 676
Total Number 700
Disease Relevance 129.87
Pain Relevance 295.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 48
pituitary 39
plasma 34
brain 30
arcuate nucleus 29
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 942 100.00 Very High Very High Very High
Enkephalin 648 100.00 Very High Very High Very High
Morphine 597 100.00 Very High Very High Very High
Inflammation 564 100.00 Very High Very High Very High
narcan 552 100.00 Very High Very High Very High
antagonist 332 100.00 Very High Very High Very High
opiate 265 100.00 Very High Very High Very High
Dynorphin 254 100.00 Very High Very High Very High
Endogenous opioid 233 100.00 Very High Very High Very High
Neuropeptide 138 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 518 100.00 Very High Very High Very High
Stress 507 100.00 Very High Very High Very High
Aids-related Complex 461 100.00 Very High Very High Very High
Pressure And Volume Under Development 238 100.00 Very High Very High Very High
Urological Neuroanatomy 191 100.00 Very High Very High Very High
Shock 55 100.00 Very High Very High Very High
Congenital Anomalies 17 100.00 Very High Very High Very High
Respiratory Failure 50 99.98 Very High Very High Very High
Heart Rate Under Development 37 99.98 Very High Very High Very High
Catalepsy 9 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin affects proopiomelanocortin gene expression in the immune organs of the rat.
Gene_expression (expression) of proopiomelanocortin
1) Confidence 0.78 Published 1995 Journal Eur. J. Endocrinol. Section Title Doc Link 8548063 Disease Relevance 0 Pain Relevance 0.10
We compared POMC gene expression in the MBH of male and female juvenile rats from 21 to 33 days of age by in situ hybridization histochemistry.
Gene_expression (expression) of POMC gene in juvenile
2) Confidence 0.78 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10446343 Disease Relevance 0 Pain Relevance 0.16
The development of POMC gene expression in the medial basal hypothalamus of prepubertal rats.
Gene_expression (expression) of POMC gene in medial
3) Confidence 0.78 Published 1999 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 10446343 Disease Relevance 0 Pain Relevance 0.18
It was demonstrated that melatonin stimulates the expression of the 3rd exon of the POMC gene in the lymph nodes and in bone marrow.
Gene_expression (expression) of POMC gene in bone marrow
4) Confidence 0.78 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8548063 Disease Relevance 0 Pain Relevance 0.07
In this study, it has been demonstrated for the first time that melatonin can act on the level of proopiomelanocortin (POMC) gene expression.
Gene_expression (expression) of proopiomelanocortin
5) Confidence 0.78 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8548063 Disease Relevance 0 Pain Relevance 0.09
Repeated reproductive experience affected the number of POMC mRNA positive cells; there were fewer cells expressing POMC mRNA in the multigravid females on day 7 of pregnancy and an increase in the number of POMC cells in the multiparous group on day 12 of lactation compared to the primiparous animals.
Gene_expression (expressing) of POMC mRNA
6) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191073 Disease Relevance 0 Pain Relevance 0
Differential proopiomelanocortin gene expression in the medial basal hypothalamus of rats during pregnancy and lactation.
Gene_expression (expression) of proopiomelanocortin in medial
7) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9191073 Disease Relevance 0 Pain Relevance 0
The results of the present study indicate that POMC gene expression changes across pregnancy and lactation and that repeated reproductive experience has long-term, possibly permanent, effects on the endogenous opioid system.
Gene_expression (expression) of POMC gene associated with endogenous opioid
8) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191073 Disease Relevance 0 Pain Relevance 0.09
In addition, the number of cells expressing POMC mRNA in multigravid animals was significantly less than in the primigravid group on days 7 and 21 of pregnancy, and on day 12 of lactation in primiparous animals.
Gene_expression (expressing) of POMC mRNA
9) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191073 Disease Relevance 0 Pain Relevance 0
delta 9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus.
Gene_expression (expression) of proopiomelanocortin in arcuate nucleus
10) Confidence 0.78 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9128838 Disease Relevance 0 Pain Relevance 0.21
The number of cells expressing POMC mRNA in the arcuate nucleus decreased in primiparous rats on day 12 of lactation when compared with the number of POMC cells in the arcuate nucleus of nulliparous rats in diestrus.
Gene_expression (expressing) of POMC mRNA in arcuate nucleus
11) Confidence 0.78 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191073 Disease Relevance 0 Pain Relevance 0
Secondly, electroporation treatment for neuropathic pain was attempted on CCI rats using plasmid DNA that expresses the POMC gene.
Gene_expression (expresses) of POMC gene associated with injury and neuropathic pain
12) Confidence 0.78 Published 2002 Journal Gene Ther. Section Abstract Doc Link 12215892 Disease Relevance 0.84 Pain Relevance 0.55
The electroporation process makes use of plasmid DNA, which expresses the POMC gene.
Gene_expression (expresses) of POMC gene
13) Confidence 0.78 Published 2002 Journal Gene Ther. Section Abstract Doc Link 12215892 Disease Relevance 0.77 Pain Relevance 0.49
To determine whether POMC gene expression changes with age and is related to reproductive status, we assessed POMC mRNA levels by in situ hybridization histochemistry in the periarcuate region of young (3-4 months), middle-aged (10-12 months), and old (17-19 months) ovariectomized rats.
Spec (whether) Gene_expression (expression) of POMC gene
14) Confidence 0.78 Published 1991 Journal Endocrinology Section Abstract Doc Link 1915074 Disease Relevance 0.08 Pain Relevance 0.22
In addition, there was a 30-40% decline in the number of cells expressing POMC mRNA in middle-aged and old animals, suggesting an overall age-related decline in POMC gene expression in middle-aged and old animals independent of reproductive status.
Gene_expression (expression) of POMC gene
15) Confidence 0.78 Published 1991 Journal Endocrinology Section Abstract Doc Link 1915074 Disease Relevance 0 Pain Relevance 0.06
In addition, there was a 30-40% decline in the number of cells expressing POMC mRNA in middle-aged and old animals, suggesting an overall age-related decline in POMC gene expression in middle-aged and old animals independent of reproductive status.
Gene_expression (expressing) of POMC mRNA
16) Confidence 0.78 Published 1991 Journal Endocrinology Section Abstract Doc Link 1915074 Disease Relevance 0 Pain Relevance 0.09
METHOD: beta-endorphin and ACTH were detected with radio-immunity, the amount of masculine cell expression of Proopiomelanocortin mRNA in hypothalamus, and brainstem of pain model was detected with in situ hybridization and NO with chemical method.
Gene_expression (detected) of beta-endorphin in brainstem
17) Confidence 0.78 Published 2002 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776573 Disease Relevance 0.10 Pain Relevance 0
RESULT: EOAD could increase beta-endorphin, NO and the amount of masculine cell expression of Proopiomelanocortin mRNA significantly in hypothalamus and brainstem of rats.
Gene_expression (expression) of Proopiomelanocortin mRNA in brainstem
18) Confidence 0.78 Published 2002 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776573 Disease Relevance 0.08 Pain Relevance 0
METHOD: beta-endorphin and ACTH were detected with radio-immunity, the amount of masculine cell expression of Proopiomelanocortin mRNA in hypothalamus, and brainstem of pain model was detected with in situ hybridization and NO with chemical method.
Gene_expression (expression) of Proopiomelanocortin mRNA in brainstem
19) Confidence 0.78 Published 2002 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776573 Disease Relevance 0.09 Pain Relevance 0
POMC gene expression exhibited a diurnal rhythm on PRO.
Gene_expression (expression) of POMC gene
20) Confidence 0.78 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2233745 Disease Relevance 0 Pain Relevance 0.06

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