INT88600

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.10
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
MNCs 4
neutrophils 3
liver 2
THP-1 2
monocytes 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 33 98.22 Very High Very High Very High
Opioid 2 96.44 Very High Very High Very High
COX2 26 93.68 High High
Inflammation 11 74.16 Quite High
metalloproteinase 2 70.52 Quite High
peptic ulcer disease 2 70.40 Quite High
Angina 8 50.00 Quite Low
Morphine 4 50.00 Quite Low
diclofenac 17 22.16 Low Low
narcan 4 10.00 Low Low
Disease Link Frequency Relevance Heat
Cirrhosis 5 98.66 Very High Very High Very High
Alagille Syndrome 4 86.88 High High
Duodenal Ulcer 2 77.76 Quite High
Infection 6 76.80 Quite High
Injury 10 75.00 Quite High
Gastritis 6 75.00 Quite High
INFLAMMATION 13 74.16 Quite High
Disease 3 70.40 Quite High
Ulcers 2 70.08 Quite High
Cv General 3 Under Development 8 63.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low pH resulted in enhancement of H. pylori-induced NF-kappaB nuclear binding.
Positive_regulation (induced) of NF-kappaB Binding (binding) of
1) Confidence 0.59 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.82 Pain Relevance 0.12
Increases in NF-kappaB nuclear binding were paralleled by decreasing amounts of cytosolic IkappaB-alpha.
Positive_regulation (Increases) of NF-kappaB Binding (binding) of
2) Confidence 0.59 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.93 Pain Relevance 0.14
RESULTS: Morphine inhibits lipopolysaccharide-induced NF-kappaB nuclear binding in human blood neutrophils and monocytes in a time-, concentration-, and naloxone-sensitive-dependent manner.
Positive_regulation (induced) of NF-kappaB Binding (binding) of in neutrophils
3) Confidence 0.45 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
Addition of recombinant human PARP-1 protein to nuclear extracts of MNCs significantly increased the DNA binding activity of NF-kappaB.
Positive_regulation (increased) of NF-kappaB Binding (activity) of in MNCs
4) Confidence 0.40 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.05 Pain Relevance 0
In cultured MNCs from healthy subjects, inhibition of PARP-1 prevented lipopolysaccharide-induced increase in DNA binding activity of NF-kappaB and the expression of TNF-alpha and IL-6.
Positive_regulation (increase) of NF-kappaB Binding (binding) of in MNCs
5) Confidence 0.40 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.06 Pain Relevance 0
Furthermore, these endomorphins further potentiated LPS-induced NF-kappaB binding.
Positive_regulation (induced) of NF-kappaB Binding (binding) of
6) Confidence 0.40 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.15
Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells.
Positive_regulation (potentiate) of NF-kappaB Binding (binding) of in THP-1 associated with cytokine
7) Confidence 0.27 Published 2002 Journal Scand. J. Immunol. Section Title Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.22
in human HSCs, the MFs of the liver, was previously described to be mediated by increased formation of nuclear factor-kappa-B (NF-?
Positive_regulation (increased) of nuclear factor-kappa-B Binding (formation) of in liver associated with cirrhosis
8) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.24 Pain Relevance 0.25
RESULTS: Morphine inhibits lipopolysaccharide-induced NF-kappaB nuclear binding in human blood neutrophils and monocytes in a time-, concentration-, and naloxone-sensitive-dependent manner.
Positive_regulation (induced) of NF-kappaB in monocytes Binding (binding) of in neutrophils
9) Confidence 0.15 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0

General Comments

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