INT88601

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.15
First Reported 2000
Last Reported 2004
Negated 2
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 2.60
Pain Relevance 7.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medulla 10
pons 3
midbrain 2
spinal cord 1
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 50 100.00 Very High Very High Very High
medulla 28 100.00 Very High Very High Very High
Endogenous opioid 6 100.00 Very High Very High Very High
narcan 14 99.94 Very High Very High Very High
Morphine 10 99.84 Very High Very High Very High
antagonist 4 99.68 Very High Very High Very High
Kinase C 9 99.34 Very High Very High Very High
Opioid 7 99.22 Very High Very High Very High
agonist 19 98.28 Very High Very High Very High
midbrain 2 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 30 99.06 Very High Very High Very High
Targeted Disruption 8 98.96 Very High Very High Very High
Sprains And Strains 12 95.12 Very High Very High Very High
Toxicity 1 89.32 High High
Hyperglycemia 4 45.80 Quite Low
Pain 2 39.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate whether repeated treatment with the mu-opioid receptor antagonist naloxone could affect G-protein activation induced by a selective mu-opioid receptor agonist [D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) in mice lacking the protein kinase Cgamma isoform monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
Regulation (affect) of Positive_regulation (activation) of G-protein associated with antagonist, agonist, narcan, enkephalin and opioid receptor
1) Confidence 0.15 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12566163 Disease Relevance 0.07 Pain Relevance 0.55
The present results indicated that the antinociceptive effect of DAMGO given supraspinally was less potent in streptozotocin-induced diabetic mice than that in non-diabetic mice, whereas the mu-opioid receptor-mediated G-protein activation in pons/medulla was unaltered in streptozotocin-induced diabetic mice.
Regulation (unaltered) of Positive_regulation (activation) of G-protein in medulla associated with medulla, diabetes mellitus, opioid receptor and antinociceptive
2) Confidence 0.10 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.90 Pain Relevance 0.73
The effect of ethanol on agonist stimulation of G-protein coupling was examined using [35S]GTPgammaS (guanosine-5'-O-(3-thio)triphosphate) binding to membranes.
Regulation (effect) of Positive_regulation (stimulation) of G-protein
3) Confidence 0.08 Published 2000 Journal Anesthesiology Section Body Doc Link 10839931 Disease Relevance 0 Pain Relevance 0
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Regulation (affect) of Positive_regulation (activation) of G-protein in medulla associated with medulla, kinase c, opioid receptor and spinal cord
4) Confidence 0.07 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.06 Pain Relevance 0.65
Up-regulation of mu-opioid receptor-mediated G-protein activation in protein kinase Cgamma knockout mice following repeated naloxone treatment.
Regulation (regulation) of Positive_regulation (activation) of G-protein associated with targeted disruption, narcan and opioid receptor
5) Confidence 0.07 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12566163 Disease Relevance 0.10 Pain Relevance 0.78
Under these conditions, no change in the G-protein activation by morphine and mu-opioid receptor expression in the lower midbrain was observed by prenatal and neonatal exposure to BPA.
Neg (no) Regulation (change) of Positive_regulation (activation) of G-protein in midbrain associated with midbrain, opioid receptor and morphine
6) Confidence 0.06 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14746872 Disease Relevance 0.09 Pain Relevance 0.53
The present results indicated that the antinociceptive effect of DAMGO given supraspinally was less potent in streptozotocin-induced diabetic mice than that in non-diabetic mice, whereas the mu-opioid receptor-mediated G-protein activation in pons/medulla was unaltered in streptozotocin-induced diabetic mice.
Regulation (unaltered) of in pons Positive_regulation (activation) of G-protein in medulla associated with medulla, diabetes mellitus, opioid receptor and antinociceptive
7) Confidence 0.03 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.90 Pain Relevance 0.73
The present study was designed to investigate the effects of these endogenous opioid peptides on G-protein activation by monitoring guanosine-5'-o-(3-[35S]thio)triphosphate binding to pons/medulla membranes of CXBK mice and their parental strain C57BL/6 ByJ mice.
Spec (investigate) Regulation (effects) of Spec (investigate) Positive_regulation (activation) of G-protein in medulla associated with medulla, endogenous opioid and sprains and strains
8) Confidence 0.03 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036217 Disease Relevance 0.18 Pain Relevance 0.75
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Regulation (affect) of in spinal cord Positive_regulation (activation) of G-protein in medulla associated with medulla, kinase c, opioid receptor and spinal cord
9) Confidence 0.02 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.06 Pain Relevance 0.65
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Regulation (affect) of in pons Positive_regulation (activation) of G-protein in medulla associated with medulla, kinase c, opioid receptor and spinal cord
10) Confidence 0.02 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.06 Pain Relevance 0.65
The present study was designed to investigate the effects of these endogenous opioid peptides on G-protein activation by monitoring guanosine-5'-o-(3-[35S]thio)triphosphate binding to pons/medulla membranes of CXBK mice and their parental strain C57BL/6 ByJ mice.
Spec (investigate) Regulation (effects) of in pons Spec (investigate) Positive_regulation (activation) of G-protein in medulla associated with medulla, endogenous opioid and sprains and strains
11) Confidence 0.01 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036217 Disease Relevance 0.18 Pain Relevance 0.75
The affinity of HmuOR for an opioid ligand and its ability to mediate the activation of a G-protein were not altered by their interaction.
Neg (not) Regulation (altered) of Positive_regulation (activation) of G-protein associated with opioid
12) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox