INT88617

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 90
Total Number 95
Disease Relevance 51.69
Pain Relevance 44.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neurons 12
brain 10
spinal cord 8
hippocampus 6
amygdala 4
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 3567 100.00 Very High Very High Very High
amygdala 2541 100.00 Very High Very High Very High
nMDA receptor 556 100.00 Very High Very High Very High
Glutamate 62 100.00 Very High Very High Very High
antagonist 60 100.00 Very High Very High Very High
Kinase C 59 100.00 Very High Very High Very High
Locus ceruleus 26 100.00 Very High Very High Very High
Analgesic 19 100.00 Very High Very High Very High
adenocard 15 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3899 100.00 Very High Very High Very High
Cold Sores 861 100.00 Very High Very High Very High
Stress 4314 99.98 Very High Very High Very High
Nociception 122 99.98 Very High Very High Very High
Frailty 29 99.80 Very High Very High Very High
Opiate Addiction 11 99.56 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 7 99.04 Very High Very High Very High
Ganglion Cysts 43 98.80 Very High Very High Very High
Anxiety Disorder 1298 98.72 Very High Very High Very High
Neurodegenerative Disease 182 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The expression of CREB-IR and pCREB-IR proteins was shown to increase for 2 wk after PSNL.
Positive_regulation (increase) of Gene_expression (expression) of CREB
1) Confidence 0.69 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042889 Disease Relevance 0.23 Pain Relevance 0
Rats given moderate spinal cord injury (SCI) display increases in the expression of the activated form of the transcription factor cyclic AMP responsive element binding protein (CREB) in spinal segments of dermatomes corresponding to permanent mechanical allodynia, a model of chronic central neuropathic pain (CNP; (Crown, E.D., Ye, Z., Johnson, K.M., Xu, G.Y., McAdoo, D.J., Westlund, K.N., Hulsebosch, C.E., 2005.
Positive_regulation (increases) of Gene_expression (expression) of CREB in Crown associated with allodynia, frailty, neuropathic pain, dermatone and spinal cord
2) Confidence 0.69 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16478624 Disease Relevance 0.75 Pain Relevance 0.55
rats based on previous findings, and on the prediction that increased CREB expression in Handled CREB rats would increase pCREB-lir.
Positive_regulation (increased) of Gene_expression (expression) of CREB
3) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.39 Pain Relevance 0.11
open arm avoidance in the EPM, and supports the notion that inducing CREB expression per se induces an anxious state
Positive_regulation (inducing) of Gene_expression (expression) of CREB in arm
4) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.66 Pain Relevance 0.18
Viral vectoring to induce CREB expression in the right lateral column of the PAG produced behavioral effects resembling those
Positive_regulation (induce) of Gene_expression (expression) of CREB in lateral column associated with central grey
5) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.52 Pain Relevance 0.12
robust effects of predator stress and virally induced CREB expression on brain and behavior.
Positive_regulation (induced) of Gene_expression (expression) of CREB in brain associated with stress
6) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.44 Pain Relevance 0.11
Thus increasing CREB expression directly and genetically in the
Positive_regulation (increasing) of Gene_expression (expression) of CREB
7) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.34 Pain Relevance 0.59
habituation [54], and direct CREB expression in PAG more powerfully
Positive_regulation (direct) of Gene_expression (expression) of CREB associated with central grey
8) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.09 Pain Relevance 0.56
that increasing CREB expression in
Positive_regulation (increasing) of Gene_expression (expression) of CREB
9) Confidence 0.69 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.21 Pain Relevance 0.41
SL327, an inhibitor of ERK activation, at doses which reduced the hyperactive pERK(1/2) levels, did not attenuated the rise in pCREB and TH immunoreactivity or plasma corticosterone secretion during morphine withdrawal, indicating that ERK kinase/ERK pathway was not directly needed for either activation of CREB and TH expression in the NTS or HPA axis hyperactivity.
Positive_regulation (activation) of Gene_expression (expression) of CREB in plasma associated with attention deficit hyperactivity disorder, withdrawal and morphine
10) Confidence 0.69 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.22 Pain Relevance 1.21
Our results show that in vivo overexpression of CREBGFP in the LC significantly aggravated particular morphine withdrawal behaviors, whereas dnCREBGFP expression attenuated these behaviors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CREB associated with locus ceruleus, withdrawal and morphine
11) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16641242 Disease Relevance 0 Pain Relevance 0.80
Intrathecal injection AS-ODN markedly suppressed the increase of CCI-induced pERK5, pCREB expression in the spinal cord.
Positive_regulation (increase) of Gene_expression (expression) of pCREB in spinal cord
12) Confidence 0.65 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0 Pain Relevance 0
Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma.
Positive_regulation (upregulated) of Gene_expression (expression) of CREB in spinal cord dorsal horn associated with dorsal horn, morphine and spinal cord
13) Confidence 0.63 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.52
The increase in pCREB expression in the BSTLD in female rats after formalin injection was confirmed with immunoblotting.
Positive_regulation (increase) of Gene_expression (expression) of pCREB
14) Confidence 0.61 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19968712 Disease Relevance 0.35 Pain Relevance 0.19
The p-CREB expression on the ipsilateral side of the spinal dorsal horn, but not on the contralateral side, increased significantly after capsaicin injection.
Positive_regulation (increased) of Gene_expression (expression) of p-CREB in dorsal horn associated with qutenza and spinal dorsal horn
15) Confidence 0.61 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.90
increased pCREB expression, which in this study would have likely begun before
Positive_regulation (increased) of Gene_expression (expression) of pCREB
16) Confidence 0.60 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.05 Pain Relevance 0.26
had elevated pCREB expression in the right dorsal PAG,
Positive_regulation (elevated) of Gene_expression (expression) of pCREB in dorsal associated with central grey
17) Confidence 0.60 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.83 Pain Relevance 0.25
that increased production of pCREB underlies right CeA-PAG potentiation.
Positive_regulation (increased) of Gene_expression (production) of pCREB associated with central grey and amygdala
18) Confidence 0.60 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.45 Pain Relevance 0.62
K252a also blocked the fluoxetine-induced expression of pCREB, supporting the role for this compound in the control of neurogenesis.
Positive_regulation (induced) of Gene_expression (expression) of pCREB associated with neurodegenerative disease and fluoxetine
19) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.40 Pain Relevance 0.43
These experiments show that (i) Fluoxetine increased Ki67 counts, as well as pCREB and Wnt3a expression in the dentate gyrus.
Positive_regulation (increased) of Gene_expression (expression) of pCREB in dentate gyrus associated with fluoxetine
20) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965105 Disease Relevance 0.07 Pain Relevance 0.63

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