INT88626

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.05
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCRN4L) nucleus (CCRN4L)
Anatomy Link Frequency
cranial 1
cerebrospinal fluid 1
brain 1
CCRN4L (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 22 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
orphanin 12 99.90 Very High Very High Very High
COX2 2 99.58 Very High Very High Very High
ischemia 14 97.92 Very High Very High Very High
cva 3 97.12 Very High Very High Very High
Endogenous opioid 2 95.32 Very High Very High Very High
antagonist 11 68.16 Quite High
Glutamate 4 49.92 Quite Low
COX-2 inhibitor 2 49.36 Quite Low
Disease Link Frequency Relevance Heat
Brain Injury 40 98.24 Very High Very High Very High
Hypoxia 19 98.24 Very High Very High Very High
Cv Unclassified Under Development 10 97.92 Very High Very High Very High
Intracranial Hypertension 3 97.12 Very High Very High Very High
Cv General 4 Under Development 4 96.76 Very High Very High Very High
Increased Venous Pressure Under Development 6 92.20 High High
Hypercapnia 3 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such elevated NOC/oFQ levels returned to control within 4 h in I+R animals and within 12 h in H+I+R animals.
Positive_regulation (elevated) of NOC
1) Confidence 0.49 Published 2000 Journal Brain Res. Section Abstract Doc Link 10841887 Disease Relevance 0.88 Pain Relevance 0.39
I+R elevated CSF NOC/oFQ from 67+/-4 to 266+/-29 pg/ml ( approximately 10(-10) M) while H+I+R elevated CSF NOC/oFQ to 483+/-67 pg/ml within 1 h of reperfusion.
Positive_regulation (elevated) of NOC
2) Confidence 0.49 Published 2000 Journal Brain Res. Section Abstract Doc Link 10841887 Disease Relevance 0.94 Pain Relevance 0.38
Unrelated studies show that the newly described opioid nociceptin orphanin FQ (NOC/oFQ) is released into cerebrospinal fluid and contributes to altered cerebral hemodynamics following hypoxia/ischemia.
Positive_regulation (contributes) of NOC in cerebrospinal fluid associated with hypoxia, ischemia, orphanin and opioid
3) Confidence 0.49 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11543945 Disease Relevance 0.94 Pain Relevance 0.48
This study was designed to investigate the relationship between NOC/oFQ, another opioid, dynorphin, and activation of the COX-2 isoform of the enzyme in such impaired dilation to NMDA after FPI in piglets equipped with a closed cranial window.
Positive_regulation (activation) of NOC in cranial associated with dynorphin, opioid and brain injury
4) Confidence 0.49 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12225656 Disease Relevance 0.62 Pain Relevance 0.52
Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.
Positive_regulation (activation) of NOC in brain associated with dynorphin, cox2 and brain injury
5) Confidence 0.45 Published 2002 Journal J. Neurotrauma Section Title Doc Link 12225656 Disease Relevance 0.66 Pain Relevance 0.61

General Comments

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