INT88638

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.17
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc18a3)
Anatomy Link Frequency
synaptic vesicles 2
Nerve 1
SPN 1
bladder 1
Pylorus 1
Slc18a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
Calcitonin gene-related peptide 12 100.00 Very High Very High Very High
Somatostatin 11 100.00 Very High Very High Very High
Neuropeptide 10 100.00 Very High Very High Very High
Cholecystokinin 6 100.00 Very High Very High Very High
gABA 6 100.00 Very High Very High Very High
Neurotransmitter 7 96.48 Very High Very High Very High
Cannabinoid receptor 35 93.68 High High
calcitonin gene related peptide 16 92.76 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 99.90 Very High Very High Very High
Overactive Bladder 50 99.64 Very High Very High Very High
Increased Venous Pressure Under Development 30 98.56 Very High Very High Very High
Pain 52 5.00 Very Low Very Low Very Low
Nociception 23 5.00 Very Low Very Low Very Low
Interstitial Cystitis 16 5.00 Very Low Very Low Very Low
Bladder Disease 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Vomiting 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied in the cell bodies and axon processes of the rat SPN the expression and the proportional coexpression of the vesicular ACh transporter-like immunoreactivity (VAChT), a specific marker of cholinergic synaptic vesicles or ChAT-like immunoreactivity (ChAT), and the peptide methionine enkephalin-like immunoreactivity (mENK), and confirmed the presence of a population of SPN peptidergic, noncholinergic varicosities.
Gene_expression (expression) of VAChT in synaptic vesicles associated with urological neuroanatomy, enkephalin and increased venous pressure under development
1) Confidence 0.57 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 0.84 Pain Relevance 0.17
We found that (i) VAChT and mENK, like ChAT-mENK, were coexpressed in only 59% of the mENK-containing varicosities, although they colocalized in the SPN cell bodies; and (ii) almost 60% of the population of mENK-containing varicosities did not express Syn or Syt, and over 80% of the mENK-containing varicosities negative for VAChT also lacked Syn.
Gene_expression (coexpressed) of VAChT in SPN associated with urological neuroanatomy and increased venous pressure under development
2) Confidence 0.57 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 1.13 Pain Relevance 0.16
Pylorus from control and denervated animals were processed for the immunocytochemical demonstration of cholecystokinin (CCK), enkephalin, gastrin-releasing peptide (GRP), somatostatin, calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), pituitary adenylate cyclase-activating peptide (PACAP), substance P (SP), vasoactive intestinal peptide (VIP), galanin, NOS, VAchT and TH.
Gene_expression (demonstration) of VAchT in Pylorus associated with neuropeptide, somatostatin, enkephalin, cholecystokinin, substance p and calcitonin gene-related peptide
3) Confidence 0.55 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.70
VAchT, TH, nNOS, and all of the peptides investigated were found in nerve fibres innervating the pyloric sphincter, and coexistence of several putative neurotransmitters were revealed.
Gene_expression (found) of VAchT in pyloric sphincter associated with neurotransmitter
4) Confidence 0.55 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.68
By contrast, aspiny interneurons that express preprosomatostatin mRNA and cholinergic interneurons that coexpress ChAT and VAChT mRNAs were CB(1) mRNA-negative.
Gene_expression (coexpress) of VAChT in interneurons
5) Confidence 0.53 Published 2000 Journal Synapse Section Abstract Doc Link 10842353 Disease Relevance 0 Pain Relevance 0.41
We studied in the cell bodies and axon processes of the rat SPN the expression and the proportional coexpression of the vesicular ACh transporter-like immunoreactivity (VAChT), a specific marker of cholinergic synaptic vesicles or ChAT-like immunoreactivity (ChAT), and the peptide methionine enkephalin-like immunoreactivity (mENK), and confirmed the presence of a population of SPN peptidergic, noncholinergic varicosities.
Gene_expression (coexpression) of VAChT in synaptic vesicles associated with urological neuroanatomy, enkephalin and increased venous pressure under development
6) Confidence 0.44 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 0.84 Pain Relevance 0.17
VAChT (vesicular acetylcholine transporter) and Viaat (vesicular inhibitory amino acid transporter, GABA and glycine release) were expected a priori to be DE between MNs and dCINs [15] and were chosen for this reason.
Gene_expression (expected) of VAChT associated with gaba
7) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.12
The co-expression of VAChT and CB receptor, and effects by CP55940, on nerve mediated contractions suggest a CB2 receptor mediated modulatory effect on cholinergic nerve activity in bladder.[34]
Gene_expression (expression) of VAChT in bladder
8) Confidence 0.16 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.18 Pain Relevance 0.19
Nerve fibers containing CB2 and VAChT were also located in the detrusor.
Gene_expression (containing) of VAChT in Nerve associated with overactive bladder
9) Confidence 0.12 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.18 Pain Relevance 0.16

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