INT88650

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 11.93
Pain Relevance 11.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
PGE2 2
muscle 1
nerve 1
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 15 100.00 Very High Very High Very High
Hyperalgesia 58 99.60 Very High Very High Very High
vincristine 6 99.44 Very High Very High Very High
ischemia 12 97.18 Very High Very High Very High
Pain 16 96.52 Very High Very High Very High
Myofascial pain syndrome 1 95.52 Very High Very High Very High
IPN 10 94.68 High High
agonist 6 94.28 High High
Lasting pain 6 93.76 High High
Action potential 1 93.68 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 71 99.60 Very High Very High Very High
Nociception 6 99.00 Very High Very High Very High
Cv Unclassified Under Development 12 97.18 Very High Very High Very High
Myalgia 1 96.80 Very High Very High Very High
Temporomandibular Joint Disorders 1 95.52 Very High Very High Very High
Inflammatory Pain 10 94.68 High High
Hypersensitivity 7 94.52 High High
Targeted Disruption 2 93.12 High High
Injury 6 91.36 High High
Neuropathic Pain 2 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hyperalgesia was acutely attenuated by intradermal injection of nonselective protein kinase C (PKC) or selective PKCepsilon inhibitors injected at the site of nociceptive testing.
Negative_regulation (inhibitors) of PKCepsilon associated with nociception, kinase c and hyperalgesia
1) Confidence 0.57 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069970 Disease Relevance 0.68 Pain Relevance 1.28
This prolonged PGE2-induced hyperalgesia was reversed by a selective inhibitor of protein kinase C-epsilon (PKCepsilon).
Negative_regulation (inhibitor) of PKCepsilon in PGE2 associated with kinase c and hyperalgesia
2) Confidence 0.51 Published 2007 Journal Burns Section Abstract Doc Link 17707592 Disease Relevance 1.62 Pain Relevance 0.92
This prolonged PGE2-induced hyperalgesia was reversed by a selective inhibitor of protein kinase C-epsilon (PKCepsilon).
Negative_regulation (inhibitor) of C-epsilon in PGE2 associated with kinase c and hyperalgesia
3) Confidence 0.51 Published 2007 Journal Burns Section Abstract Doc Link 17707592 Disease Relevance 1.62 Pain Relevance 0.92
Antisense oligodeoxynucleotide was employed to produce a decrease in PKCepsilon in the nerve, verified by Western blot analysis.
Negative_regulation (decrease) of PKCepsilon in nerve
4) Confidence 0.47 Published 2003 Journal Neuroscience Section Abstract Doc Link 12849754 Disease Relevance 1.02 Pain Relevance 0.67
The finding that transient inhibition of PKCepsilon can not only prevent the development of priming, but can also terminate a fully developed state of priming suggests the possibility that selective targeting PKCepsilon might be an effective new strategy in the treatment of chronic inflammatory pain.
Negative_regulation (inhibition) of PKCepsilon associated with ipn
5) Confidence 0.47 Published 2003 Journal Neuroscience Section Abstract Doc Link 12849754 Disease Relevance 0.99 Pain Relevance 0.67
Inhibition of protein kinase C epsilon (PKC epsilon ) attenuated vincristine-induced hyperalgesia in males and ovariectomized females, but not in normal females or in estrogen-replaced ovariectomized females.
Negative_regulation (Inhibition) of PKC epsilon associated with vincristine, hyperalgesia and kinase c
6) Confidence 0.38 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809704 Disease Relevance 0.89 Pain Relevance 1.27
GJ permeability during ischemia, which was assessed by Lucifer yellow, was reduced by DADLE to 47% of the control level, and this effect of DADLE was almost abolished by a PKC-epsilon inhibitor [PKC-epsilon translocation inhibitory peptide (PKC-epsilon-TIP)] but was not affected by a PKC-delta inhibitor (rottlerin).
Negative_regulation (inhibitor) of PKC-epsilon associated with ischemia
7) Confidence 0.31 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.49 Pain Relevance 0.54
GJ permeability during ischemia, which was assessed by Lucifer yellow, was reduced by DADLE to 47% of the control level, and this effect of DADLE was almost abolished by a PKC-epsilon inhibitor [PKC-epsilon translocation inhibitory peptide (PKC-epsilon-TIP)] but was not affected by a PKC-delta inhibitor (rottlerin).
Negative_regulation (inhibitor) of PKC-epsilon associated with ischemia
8) Confidence 0.31 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.49 Pain Relevance 0.54
In normal male but not female rats, epinephrine-induced mechanical hyperalgesia was antagonized by inhibitors of protein kinase Cepsilon (PKCepsilon), protein kinase A (PKA) and nitric oxide synthetase (NOS).
Negative_regulation (inhibitors) of PKCepsilon associated with hyperalgesia
9) Confidence 0.21 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11454025 Disease Relevance 0.65 Pain Relevance 0.56
In normal male but not female rats, epinephrine-induced mechanical hyperalgesia was antagonized by inhibitors of protein kinase Cepsilon (PKCepsilon), protein kinase A (PKA) and nitric oxide synthetase (NOS).
Negative_regulation (inhibitors) of protein kinase Cepsilon associated with hyperalgesia
10) Confidence 0.18 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11454025 Disease Relevance 0.65 Pain Relevance 0.56
A nonselective inhibitor of several PKC isozymes and a selective PKCepsilon inhibitor antagonized this prolonged hyperalgesic response equally.
Negative_regulation (inhibitor) of PKCepsilon associated with hyperalgesia
11) Confidence 0.16 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10844037 Disease Relevance 0.94 Pain Relevance 0.92
Injection of 5- and 12-lipoxygenase produced hyperalgesia that was not antagonized by inhibitors of PKA, PKCepsilon or MAPK.
Negative_regulation (inhibitors) of PKCepsilon associated with hyperalgesia
12) Confidence 0.08 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12582831 Disease Relevance 0.73 Pain Relevance 0.89
Thus, selective targeting of peripheral mGluR 5 and PKCalpha, as well as PKCepsilon, might serve as an effective therapeutic strategy in the management of chronic muscle pain conditions, such as temporomandibular disorders.
Negative_regulation (targeting) of PKCepsilon in muscle associated with pain, myofascial pain syndrome and myalgia
13) Confidence 0.02 Published 2007 Journal Neuroscience Section Abstract Doc Link 17306466 Disease Relevance 0.52 Pain Relevance 0.51
Local injection of dominant active MEK produced hyperalgesia that was unaffected by PKA or PKCepsilon inhibitors.
Neg (unaffected) Negative_regulation (inhibitors) of PKCepsilon associated with hyperalgesia
14) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.65 Pain Relevance 0.91

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