INT8866

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 18.06
Pain Relevance 5.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAT) mitochondrion (TAT) small molecule metabolic process (TAT)
biosynthetic process (TAT) cellular nitrogen compound metabolic process (TAT) cellular_component (TAT)
Anatomy Link Frequency
plasma 5
lumen 2
skin 2
heart 1
body 1
TAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 33 99.84 Very High Very High Very High
Pain 31 99.38 Very High Very High Very High
aspirin 10 98.00 Very High Very High Very High
anesthesia 8 96.64 Very High Very High Very High
ischemia 10 95.04 Very High Very High Very High
abdominal pain 2 90.04 High High
Catecholamine 3 89.60 High High
headache 3 84.40 Quite High
backache 1 84.36 Quite High
Paracetamol 2 83.32 Quite High
Disease Link Frequency Relevance Heat
Sarcoma 7 100.00 Very High Very High Very High
Cv General 3 Under Development 30 99.84 Very High Very High Very High
Coronary Artery Disease 18 99.84 Very High Very High Very High
Pain 25 99.38 Very High Very High Very High
Sickle Cell Anemia 16 99.28 Very High Very High Very High
Acute Liver Failure 18 98.96 Very High Very High Very High
Heart Rate Under Development 3 98.82 Very High Very High Very High
Diabetes Mellitus 16 98.52 Very High Very High Very High
Lateral Sinus Thrombosis 3 97.96 Very High Very High Very High
Opportunistic Infections 1 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Marked elevation of Thrombin-Antithrombin III complex (TAT) and Plasmin-alpha 2 Plasmin inhibitor complex (PIC) indicated the activation of both coagulation and fibrinolysis in the false lumen.
Positive_regulation (elevation) of TAT in lumen
1) Confidence 0.67 Published 1992 Journal Kokyu To Junkan Section Abstract Doc Link 1381516 Disease Relevance 0.09 Pain Relevance 0.09
Patients with colorectal cancer showed initially an altered balance of hemostasis with a preponderance of procoagulant activity and fibrinolytic inhibition, as noted by marginally elevated TAT and PAI-1 plasma levels.
Positive_regulation (elevated) of TAT in plasma associated with colon cancer
2) Confidence 0.67 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738072 Disease Relevance 0.70 Pain Relevance 0.27
Patients with unstable angina (UA), and congestive heart failure (CHF) did not differ from controls with respect to F(1+2), and TAT was elevated in UA patients (6.05 +/- 1.15 ng/ml, p = 0.033) when compared with controls (3.34 +/- 0.20 ng/ml).
Positive_regulation (elevated) of TAT in heart associated with heart rate under development and angina
3) Confidence 0.67 Published 1999 Journal Cardiology Section Abstract Doc Link 10640797 Disease Relevance 1.66 Pain Relevance 0.78
A decrease in the platelet count and an increase in the plasma levels of thrombin-antithrombin III complex (TAT) and fibrin degradation products (FDPs) indicated the presence of subclinical intravascular coagulation.
Positive_regulation (increase) of TAT in plasma associated with disseminated intravascular coagulation
4) Confidence 0.67 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.49 Pain Relevance 0.13
CONCLUSION: Endovascular intervention results in a significant increase in TAT and D-dimer.
Positive_regulation (increase) of TAT
5) Confidence 0.67 Published 2005 Journal J. Vasc. Surg. Section Body Doc Link 16102623 Disease Relevance 0.05 Pain Relevance 0
In patients but not in control subjects, exercise of similar intensity elevated circulating concentrations of TAT (from 3.43+/-1.45 to 4.83+/-2.27 ng/mL; P<.05).
Positive_regulation (elevated) of TAT
6) Confidence 0.67 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9484989 Disease Relevance 0.78 Pain Relevance 0.24
Increased TAT indicates a procoagulant state, and increased PAI antigen indicates a hypofibrinolytic state.
Positive_regulation (Increased) of TAT
7) Confidence 0.67 Published 2006 Journal J. Vasc. Surg. Section Body Doc Link 16414385 Disease Relevance 0 Pain Relevance 0
During the anhepatic phase, a significant increase in levels of tissue plasminogen activator, thrombin-antithrombin complexes (TAT) and D-dimers (DD) was noted in both groups.
Positive_regulation (increase) of TAT
8) Confidence 0.67 Published 1997 Journal Hepatology Section Abstract Doc Link 9362354 Disease Relevance 0.21 Pain Relevance 0.09
Marked elevation of fibrinogen, thrombin-antithrombin III complex (TAT), plasmin-alpha(2) plasmin inhibitor complex (PIC), fibrin degradation products (FDP), and D-Dimer indicated the activation of both coagulation and fibrinolysis in the false lumen.
Positive_regulation (elevation) of TAT in lumen
9) Confidence 0.67 Published 1996 Journal Kyobu Geka Section Abstract Doc Link 8913071 Disease Relevance 0.34 Pain Relevance 0.08
The level of thrombin-antithrombin III complex (TAT) was markedly increased in Patient 1.
Positive_regulation (increased) of TAT
10) Confidence 0.67 Published 1996 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8752690 Disease Relevance 1.21 Pain Relevance 0.25
Both F1 + 2 and TAT levels were increased in patients with angiographically verified coronary atherosclerosis as compared to patients with angina and angiographically normal coronaries (F1 + 2: 1.76 vs 1.36 nmol/l, TAT: 2.35 vs 2.00 micrograms/l; p-values after adjusting for age, sex and past history of myocardial infarction 0.06 and 0.11 respectively).
Positive_regulation (increased) of TAT associated with angina, coronary artery disease and myocardial infarction
11) Confidence 0.67 Published 1993 Journal Thromb. Haemost. Section Abstract Doc Link 8115978 Disease Relevance 0.68 Pain Relevance 0.31
Exercise induced a significant and parallel increase in both the TAT and the F1 + 2 levels (but not of the DD levels) in the three groups.
Positive_regulation (increase) of TAT
12) Confidence 0.67 Published 1992 Journal Thromb. Res. Section Abstract Doc Link 1604440 Disease Relevance 0.76 Pain Relevance 0.34
TAT levels were increased in CAD, and significantly so in the diabetic group. tPA levels were increased only in the CAD patients without diabetes.
Positive_regulation (increased) of TAT associated with coronary artery disease and diabetes mellitus
13) Confidence 0.67 Published 1991 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 1772997 Disease Relevance 2.42 Pain Relevance 0.38
As compared with control subjects, asymptomatic subjects with SCD demonstrated significantly increased platelet activation (P <.01 for P-selectin and annexin V binding), elevated plasma levels of PF4 and betaTG (P <.01 and P <.03, respectively), and increased plasma concentrations of F(1.2), TAT, PAP, and D -dimer (P <.05 in all cases).
Positive_regulation (increased) of TAT in plasma associated with sickle cell anemia
14) Confidence 0.67 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.86 Pain Relevance 0.42
Thus, using a simple and rapid technique, we have been able to demonstrate increased levels of TAT complex in patients with FHF.
Positive_regulation (increased) of TAT associated with acute liver failure
15) Confidence 0.67 Published 1990 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2127751 Disease Relevance 0.76 Pain Relevance 0.08
Although plasma levels of TAT were significantly elevated in patients with CSA (p < 0.01 vs C), they were much higher in patients with AIS (p < 0.001 vs CSA).
Positive_regulation (elevated) of TAT in plasma associated with angina
16) Confidence 0.67 Published 1994 Journal Thromb. Res. Section Abstract Doc Link 7974387 Disease Relevance 0.69 Pain Relevance 0.54
Thrombin is inhibited in circulation by antithrombin III, and measurement of the thrombin-antithrombin III complex (TAT) is a direct measure of thrombin formation.
Positive_regulation (measurement) of TAT
17) Confidence 0.49 Published 1990 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2127751 Disease Relevance 0.81 Pain Relevance 0
Sections explore the etiology and pathogenesis of KS, rationale for systemic treatment, single-agent chemotherapy, combination chemotherapy, chemotherapy and antiretroviral agents, interferon, interferon and antiretroviral therapy, interferon and chemotherapy, other biological agents, angiostatic compounds, and anti-Tat therapy.
Positive_regulation (explore) of Tat associated with sarcoma
18) Confidence 0.49 Published 1994 Journal AIDS Section Abstract Doc Link 7519018 Disease Relevance 1.08 Pain Relevance 0.12
A significant increment of TAT was observed in group A during reperfusion.
Positive_regulation (increment) of TAT
19) Confidence 0.49 Published 1997 Journal Hepatology Section Abstract Doc Link 9362354 Disease Relevance 0.20 Pain Relevance 0.08
The thrombin-anti-thrombin III complex (TAT) levels at T(1) in Group G+E and G were significantly increased as compared with those at Group E (P<0.01), and subsequently recovered to pre-anesthesia following surgery.
Positive_regulation (increased) of TAT
20) Confidence 0.45 Published 2004 Journal Beijing Da Xue Xue Bao Section Body Doc Link 15303131 Disease Relevance 0 Pain Relevance 0

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