INT88667

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.53
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
monocyte 2
platelet 2
foramen ovale 2
F2 (Homo sapiens)
F2 - G20210A (1)
Pain Link Frequency Relevance Heat
abdominal pain 3 95.68 Very High Very High Very High
carbamazepine 58 94.92 High High
Restless leg syndrome 120 93.92 High High
Inflammation 62 92.72 High High
cva 6 88.16 High High
aspirin 23 88.08 High High
Migraine 1 78.64 Quite High
Angina 6 76.32 Quite High
alcohol 1 66.24 Quite High
Inflammatory response 13 59.28 Quite High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 1 100.00 Very High Very High Very High
Thrombosis Related Under Development 6 99.62 Very High Very High Very High
Myocardial Infarction 35 99.12 Very High Very High Very High
Injury 20 98.36 Very High Very High Very High
Stroke 8 96.84 Very High Very High Very High
Patent Foramen Ovale 5 95.92 Very High Very High Very High
Abdominal Pain 3 95.68 Very High Very High Very High
Increased Venous Pressure Under Development 124 93.92 High High
INFLAMMATION 84 92.72 High High
Thrombophilia 1 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mesenteric venous thrombosis in a patient with prothrombin 20210A mutation and antithrombin III deficiency: challenges to conventional anticoagulation--a case report.
Negative_regulation (deficiency) of Gene_expression (mutation) of prothrombin associated with thrombosis related under development
1) Confidence 0.41 Published 2003 Journal Vasc Endovascular Surg Section Title Doc Link 12894373 Disease Relevance 0.47 Pain Relevance 0.18
Our results show that unfractionated and low molecular weight heparins potently inhibit monocytic tissue factor induced thrombin generation.
Negative_regulation (inhibit) of Gene_expression (generation) of thrombin
2) Confidence 0.37 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.08
It is well known that unfractionated heparin and low molecular weight heparins inhibit extrinsic thrombin generation.
Negative_regulation (inhibit) of Gene_expression (generation) of thrombin
3) Confidence 0.37 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0
Comparative inhibition of LPS-activated human monocyte-induced thrombin generation by unfractionated heparin and low molecular weight heparins.
Negative_regulation (inhibition) of Gene_expression (generation) of thrombin in monocyte
4) Confidence 0.37 Published 1999 Journal Haemostasis Section Title Doc Link 10844403 Disease Relevance 0 Pain Relevance 0
Because statins can reduce thrombin generation (13) and platelet activation (20) after injury in stable patients, both processes may have been relatively more vigorous in the HG group than in the DM and NG groups.
Negative_regulation (reduce) of Gene_expression (generation) of thrombin in platelet associated with injury
5) Confidence 0.35 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.81 Pain Relevance 0
These observations were supported by the fact that DEGR–factor Xa, a catalytically inactive factor Xa derivative that selectively blocks production of thrombin, also had no influence on organ failure in this model.
Negative_regulation (blocks) of Gene_expression (production) of thrombin
6) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.44 Pain Relevance 0.12
Thrombin is the APC activator, and APC is a feedback inhibitor for thrombin generation [22,23].
Negative_regulation (inhibitor) of Gene_expression (generation) of thrombin
7) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.58 Pain Relevance 0
The initial laboratory findings were as follows: hematocrit, 41.5; prothrombin time, 12.3 seconds (reference range 11 to 13 seconds); international normalized ratio, 1.02; creatinine, 0.97 mg/dl (reference range 0.5 to 1.10 mg/dl); glucose, 102 mg/dl (reference range 70 to 110 mg/dl); serum alanine aminotransferase, 16 U/L (reference range 10 to 37 U/l); aspartate aminotransferase, 17 U/l (reference range 10 to 40 U/l); alkaline phosphatase, 238 U/l (reference range 0 to 270 U/l); ?
Negative_regulation (follows) of Gene_expression (time) of prothrombin
8) Confidence 0.05 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2495000 Disease Relevance 0.88 Pain Relevance 0.24
Statin therapy has been shown to reduce thrombin generation, and it is unclear what effect it may have on response to exercise in these patients [18].
Negative_regulation (reduce) of Gene_expression (generation) of thrombin
9) Confidence 0.03 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.51 Pain Relevance 0.37
This finding which is more pronounced in the patient group has occurred despite the use of statins which have been shown to reduce thrombin generation [18].
Negative_regulation (reduce) of Gene_expression (generation) of thrombin
10) Confidence 0.03 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.52 Pain Relevance 0.47
We assessed the occurrence of several prothrombotic states (factor V Leiden, prothrombin G20210A, deficiencies in protein S, protein C and antithrombin, lupus anticoagulant, anticardiolipin antibodies, elevated factor VIII, resistance to activated protein C) and classical risk factors for venous thrombosis in 57 adult patients with cryptogenic stroke and patent foramen ovale and in 104 matched controls.
Negative_regulation (deficiencies) of Gene_expression (resistance) of prothrombin G20210A (G20210A) in foramen ovale associated with patent foramen ovale, stroke, thrombosis related under development and systemic lupus erythematosus
11) Confidence 0.00 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12695749 Disease Relevance 1.32 Pain Relevance 0.16

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