INT88676

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Context Info
Confidence 0.30
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP27B1) small molecule metabolic process (CYP27B1) cytoplasm (CYP27B1)
Anatomy Link Frequency
parathyroid 2
CYP27B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 12 67.36 Quite High
Inflammation 3 26.60 Quite Low
Paracetamol 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 13 99.32 Very High Very High Very High
Hypocalcemia 7 93.60 High High
Hypercalcemia 10 92.24 High High
Renal Failure 1 86.16 High High
Parathyroid Disease 1 85.44 High High
Hypophosphatemia 2 84.20 Quite High
Rickets 3 78.40 Quite High
Pain 14 67.36 Quite High
Muscular Spasm 1 66.96 Quite High
Osteoporosis 57 60.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patho-physiologic observations suggested that the tumor secreted some humoral substances inhibiting 25-hydroxyvitamin D-1 alpha-hydroxylase activity, renal phosphate resorption, and parathyroid hormone production.
Negative_regulation (inhibiting) of alpha-hydroxylase in parathyroid associated with cancer
1) Confidence 0.30 Published 1996 Journal Pathol. Int. Section Abstract Doc Link 10846577 Disease Relevance 0.91 Pain Relevance 0.07
If there are any concerns, it may be prudent to assay serum 25-hydroxyvitamin D, parathyroid hormone, calcium, and phosphorus levels.
Negative_regulation (assay) of serum 25-hydroxyvitamin in parathyroid
2) Confidence 0.02 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 1.04 Pain Relevance 0

General Comments

This test has worked.

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