INT88678

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.11
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP27B1) small molecule metabolic process (CYP27B1) cytoplasm (CYP27B1)
Anatomy Link Frequency
liver 3
parathyroid 1
CYP27B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 2 96.68 Very High Very High Very High
agonist 5 84.72 Quite High
Pain 32 77.60 Quite High
electroacupuncture 1 30.56 Quite Low
Acupuncture 1 26.88 Quite Low
Osteoarthritis 2 15.56 Low Low
Potency 10 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 12 98.66 Very High Very High Very High
Stress 24 88.76 High High
Aging 45 87.20 High High
Breast Cancer 10 83.24 Quite High
Hypophosphatemia 2 82.88 Quite High
Pain 21 77.60 Quite High
Rickets 4 77.08 Quite High
Toxicity 19 68.32 Quite High
Lymphopenia 5 66.28 Quite High
Muscular Spasm 1 65.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fish, this effect is mediated through an estrogen receptor–dependent mechanism (Navas and Segner 2001), as is the case in mammals where estrogens decrease cyp1a expression by altering recruitment of the transcription factor nuclear factor-1 to the AhR, a process that normally increases cyp1a transcription (Ricci et al. 1999).
Gene_expression (expression) of cyp1a
1) Confidence 0.75 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0.04
Expression of the cyp1a gene was also measured in liver by real-time PCR.


Gene_expression (Expression) of cyp1a in liver
2) Confidence 0.75 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0
In addition estrogen increases expression of the Vitamin D receptor and VDR gene via activation of ERK 1/2 signaling pathway [47, 48].
Gene_expression (expression) of VDR
3) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2943085 Disease Relevance 0.66 Pain Relevance 0.21
Health effects were determined using a battery of end points indicative of growth effects [length, weight, condition factor, and hepatic expression of the gene for the somatotropic hormone insulin-like growth factor-1 (igf1)], genotoxicity (comet assay), immunotoxicity [differential white blood cell (WBC) count and phagocytotic activity of liver cells], and metabolic responses [hepatic ethoxy-resorufin-O-deethylase (EROD) activity and cytochrome P450 1a (cyp1a) and 3a (cyp3a) gene expression, as indicators of phase I bio-transformation, and glutathione S-transferase (gst) gene expression, as an indicator of phase II biotransformation].
Gene_expression (expression) of cyp1a in liver
4) Confidence 0.65 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0
Health effects were determined using a battery of end points indicative of growth effects [length, weight, condition factor, and hepatic expression of the gene for the somatotropic hormone insulin-like growth factor-1 (igf1)], genotoxicity (comet assay), immunotoxicity [differential white blood cell (WBC) count and phagocytotic activity of liver cells], and metabolic responses [hepatic ethoxy-resorufin-O-deethylase (EROD) activity and cytochrome P450 1a (cyp1a) and 3a (cyp3a) gene expression, as indicators of phase I bio-transformation, and glutathione S-transferase (gst) gene expression, as an indicator of phase II biotransformation].
Gene_expression (expression) of cyp1a in liver
5) Confidence 0.65 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0
In both experiments, effluent exposure induced hepatic EROD activity (Figure 4A), and this was typically associated with parallel inductions of hepatic cyp1a expression (Figure 4B).
Gene_expression (expression) of cyp1a
6) Confidence 0.58 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.07 Pain Relevance 0
Furthermore, specific periods of the life cycle were identified that display a higher number of genes with sex-specific expression which included putative toxicological susceptibility related genes (e.g., Cyp2d4, Cyp3a23/3a1, Gstm1, Slc22a8).
Gene_expression (expression) of Cyp
7) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.18 Pain Relevance 0
Patho-physiologic observations suggested that the tumor secreted some humoral substances inhibiting 25-hydroxyvitamin D-1 alpha-hydroxylase activity, renal phosphate resorption, and parathyroid hormone production.
Gene_expression (production) of alpha-hydroxylase in parathyroid associated with cancer
8) Confidence 0.48 Published 1996 Journal Pathol. Int. Section Abstract Doc Link 10846577 Disease Relevance 0.90 Pain Relevance 0.07
Expression profiles for specific examples of genes found in xenobiotic metabolism pathways (Cyp2c11, Cyp2e1, Cyp3a23/3a1, Gstm1, glutathione-s-transferase mu 1; Slc22a8, solute carrier family 22 member 8) and energy metabolism (Phgdh, 3-phosphoglycerate dehydrogenase), which exhibit notable sex and age related differences, are shown in Figure 7.


Gene_expression (Expression) of Cyp associated with member 8
9) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.30 Pain Relevance 0.10

General Comments

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